Pathology of infection and rejection in serial biopsies from liver homografts

Houthoff, H. J.; Eggink, Hf; Haagsma, Elizabeth B.; Gips, C. H.; Krom, Ruud A.F.

doi:10.1007/978-94-009-5018-4_15

Cited by 2 publications

(2 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Histological features of PBC and chronic rejection do overlap each other; both are characterized by the so-called nonsuppurative type of destructive cholangitis leading to vanishing of bile ducta. In rejection, vascular changes are found, whereas in PBC granulomas may occur (20)(21)(22). The autoimmune hypothesis of PBC has emerged from the resemblance of graft-versus-host disease in bone marrow transplant patients with PBC patients (23).…”

Section: Discussionmentioning

confidence: 99%

Subtypes of antimitochondrial antibodies in primary biliary cirrhosis before and after orthotopic liver transplantation

et al. 1987

View full text Add to dashboard Cite

Antimitochondrial antibodies are markers for primary biliary cirrhosis and probably reflect a specific defect in immunoregulation underlying this disease. Antimitochondrial antibodies and their primary biliary cirrhosis-specific subtypes were tested before and up to 6 years after orthotopic liver transplantation. Sera from 31 consecutive patients were tested, 15 patients had primary biliary cirrhosis and 16 non-primary biliary cirrhosis. Antimitochondrial antibodies were investigated under code by immunofluorescence, and primary biliary cirrhosis-specific subtypes were determined by radioimmunoassay (anti-p62, anti-p48) and complement fixation test (anti-M2, anti-M4, anti-M8). Before orthotopic liver transplantation, antimitochondrial antibodies were detected by immunofluorescence in 13 of 15 patients with primary biliary cirrhosis. Of these patients, 12 were positive for anti-p62 and 8 for anti-p48. Ten patients were positive for anti-M2, 4 patients for anti-M4 and 7 patients for anti-M8. Two primary biliary cirrhosis patients and all non-primary biliary cirrhosis patients were negative with all tests. One month after orthotopic liver transplantation, antimitochondrial antibodies titers declined or became negative by antimitochondrial antibodies immunofluorescence, 3 patients became negative by radioimmunoassay for anti-p62 and 1 for anti-p48. With complement fixation test, 4 patients became negative for anti-M2, 2 for anti-M4 and 4 for anti-M8. Antimitochondrial antibody titer reduction observed 1 month after orthotopic liver transplantation remained unchanged in most sera during the following years. A rise was observed in two patients after 4 and 5 years.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

Section: Discussionmentioning

confidence: 99%

Subtypes of antimitochondrial antibodies in primary biliary cirrhosis before and after orthotopic liver transplantation

et al. 1987

View full text Add to dashboard Cite

show abstract

“…19], VOD belongs to the spectrum of changes seen in chronic rejection after liver transplant [20], Clinical manifestations might be minimal or very serious, i.e., ascites with bleeding varices. It is a small-vessel dis ease with collagen deposits obstructing flow in the areas around terminal hepatic venules, which may resemble changes seen in alco holic liver disease.…”

Section: Veno-occlusive Disease (Vod) Andmentioning

confidence: 99%

Assessment of Portal Hypertension: Understanding Will Improve Treatment

Leeuwen

1991

Dig Dis

View full text Add to dashboard Cite

Pathology of infection and rejection in serial biopsies from liver homografts

Cited by 2 publications

References 9 publications

Subtypes of antimitochondrial antibodies in primary biliary cirrhosis before and after orthotopic liver transplantation

Subtypes of antimitochondrial antibodies in primary biliary cirrhosis before and after orthotopic liver transplantation

Assessment of Portal Hypertension: Understanding Will Improve Treatment

Contact Info

Product

Resources

About