Pathology of Liver Metastases

Centeno, Barbara A.

doi:10.1177/107327480601300103

Cited by 51 publications

(32 citation statements)

References 84 publications

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“…This was in accordance with the observations which were made by Sainath et al and Shamshad et al 2,13 In our study in the liver, the most common malignant lesion was metastatic adenocarcinoma followed by HCC which is comparable to the study of Tasleem et al, Aftab et al, Shamshad et al and most of western literature, in which the most common hepatic malignancy was metastatic carcinoma. 9,10,13,14,15,16 The observations of our study were not similar to those of some other Indian studies, where hepatocellular carcinoma constituted the most common hepatic malignancy. 2,4 In our study we observed 5.3% inconclusive smears, which was lower than the observations made by Tasleem et al, Shamshad et al and Aftab A Khan et al who observed 9.43%, 6.5% and 6% unsatisfactory smears, 9,13,10 which could be attributed to many reasons and depends on many factors like location, size, accessibility, vascularity, necrotic component, consistency, nature and histologic type of the lesion.…”

Section: Discussioncontrasting

confidence: 55%

A Study of Ultrasound-Guided Fine Needle Aspiration Cytology in Various Intraabdominal and Pelvic Lumps With Histopathological Correlation

Purwar¹,

Omhare²,

Gupta³

et al. 2018

jemds

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BACKGROUNDIn surgical practice evaluation of deep, abdomino-pelvic masses or focal lesions involving abdominal sites is often difficult and challenging. Distinction between malignant and non-malignant lesions and particularly inflammatory lesions is vital for patient management. It is mandatory to make a documentary evidence of the nature of the lesion before the institution of therapy and for the prognosis. Nowadays, FNAC is a very good alternative for surgical procedures like diagnostic laparotomy. Aims and Objectives-To study the cytomorphological features, age and sex distribution of intra-abdominal lesions; to categorise them as inflammatory, benign and malignant lesions with histopathological correlation; and to evaluate the sensitivity, specificity and diagnostic accuracy. MATERIALS AND METHODSIt is a descriptive type of study that included 94 patients with clinically or sonologically diagnosed abdomino-pelvic masses. FNAC was performed under US guidance. The aspirates were smeared into a minimum of 2 slides and they were routinely stained with H and E, MGG stain. RESULTSIn this study, 94 cases of intra-abdominal lumps were subjected to USG guided FNAC. Out of 94 cases there were 68 (72.4%) malignant, 10 (10.6%) benign, 11 (11.7%) inflammatory and 05 (5.3%) unsatisfactory smears. In our study, liver and the gall bladder were the most common sites. Adenocarcinomas and hepatocellular carcinomas were the most common malignant lesions. This study showed 91.4% sensitivity, 100% specificity, 100% positive predictive value, 83.3% negative predictive value and diagnostic accuracy of 94%. CONCLUSIONIntra-abdominal FNAC is widely accepted as a simple, economical and a safe OPD procedure in the presence of expert cytopathologist with high sensitivity, specificity and diagnostic accuracy, and it can be used as important diagnostic tool for a preoperative diagnosis and management of intra-abdominal lesions. Most of the intra-abdominal masses are non-palpable and even if they are palpable the idea of their size and shape and the extent of the lesion is not possible. Use of imaging modalities like fluoroscopy, CT and USG helps in localisation of lesions and also improved adequacy of sample. 1 'Financial or Other Competing Interest': None. Submission 10-09-2017, Peer Review 20-01-2018, Acceptance 27-01-2018, Published 05-02-2018. Corresponding Author: Neetu Purwar, #35/New Type 4, GSVM Medical College, Kanpur-208002, U. P. E-mail: neetu.purwar@gmail.com DOI: 10.14260/jemds/2018 Ultrasound guided FNAC is a common and widely accepted as a safe diagnostic procedure in which any structure visualised can be reached quickly and precisely by a fine needle and it is substitute for surgical procedures like diagnostic laparotomy. 2 FNAC is a highly sensitive, highly specific, accurate and a cost effective diagnostic procedure as shown in most studies with a negligible complication rate. 3,4,5,6 However, an absolute contraindication is uncorrectable severe coagulopathy. 7 Liver is an abdominal organ for which perc...

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Section: Discussioncontrasting

confidence: 55%

A Study of Ultrasound-Guided Fine Needle Aspiration Cytology in Various Intraabdominal and Pelvic Lumps With Histopathological Correlation

Purwar¹,

Omhare²,

Gupta³

et al. 2018

jemds

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“…(3,8,17) Second most common site of aspiration was gall bladder as found by Reyaz TA et al (2016) (12) In retroperitoneal masses renal cell carcinoma was most common malignant lesion of kidney. In a study by Adhikari RC et al (2010) (1) same results were reported.…”

Section: Discussion:-mentioning

confidence: 61%

Role of Usg Guided Fnac in Diagnosis of Intra-Abdominal and Intrapelvic Masses.

Naiding¹,

Goswami²,

Singh³

2017

IJAR

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Image guided cytology is emerging as less invasive, cost effective procedure with remarkable sensitivity, specificity and diagnostic yield to enhance the diagnostic accuracy of imaging modalities for deep seated lesion. Aim: The aim of our study was to analyse the usefulness of ultrasound guided fine needle aspiration cytology in the diagnosis of intraabdominopelvic masses and to assess the cytomorphological features of various lesions with their Age and sex distribution pattern. Materials and Methods:The study included 57 clinically and radiologically suspected palpable and non-palpable intraabdominopelvic lesions. USG guided FNAC was done in all the nonpalpable lesion and for a few selected palpable lesions. Giemsa's and Papanicolaou's stains were used. Results: Cases were reported in age range of 2-78 years with a M: F of 1.3:1. There were 37 (64.91%) malignant, 15 (26.31%) benign and 5 (8.77%) inconclusive cases. Liver and gallbladder were most common involved sites. This study showed 100% specificity and 95% sensitivity for malignant lesions. Diagnostic yield was 91.2%. Conclusion: USG guided FNA cytology is a simple and safe procedure. It can be utilized as a pre-operative procedure for the management of intra-abdominopelvic lesions.

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“…Characterization of tumor microenvironment holds a key role in the attempt to understand the mechanism of primary and secondary liver carcinogenesis, its immune component, responsible for the development of an immune response of the host against the tumor, being the main point of interest [1][2][3][4]. The largely inconsistent biological behavior of primary and secondary liver tumors could be also explained by the settled relationship between the tumoral component and microenvironment [1,5,6].…”

Section: Introductionmentioning

confidence: 99%

“…The largely inconsistent biological behavior of primary and secondary liver tumors could be also explained by the settled relationship between the tumoral component and microenvironment [1,5,6].…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis of CD4 and CD8 lymphocytes — evidences for different distribution in primary and secondary liver tumors

Giuşcă

Wierzbicki

Amălinei

et al. 2015

Folia Histochem Cytobiol.

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Introduction. The impact of tumor cells on tumor-infiltrating lymphocytes (TILs) in cancer developmentis not yet clarified. Our study analyzed the distribution and prognostic value of CD4+ and CD8+ T lymphocytes in hepatocellular carcinoma (HCC) and liver metastases (LM). Material and methods. Archival tissue specimens of 35 HCC and 39 LM patients were immunohistochemically processed. The number of intratumoral (IT) and peritumoral (PT) CD4+ and CD8+ T cells was quantitatively analyzed. Results.We noted large variances of T lymphocyte subpopulations. Similar number of CD4+ and CD8+ lymphocytes was present in HCC, whereas in LM the number of CD8+ cells was approximately two times higher than CD4+ lymphocytes. A significant prevalence of T cells in PT over IT areas was observed. The prognostic value was demonstrated only for PT CD8+ lymphocytes in LM, their reduced number being associated with shorter survival. Conclusions. The differences between proportions of T lymphocytes within tumor and its environment might be explained by proapoptotic effect of cancer cells on TILs.

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Pathology of Liver Metastases

Cited by 51 publications

References 84 publications

A Study of Ultrasound-Guided Fine Needle Aspiration Cytology in Various Intraabdominal and Pelvic Lumps With Histopathological Correlation

A Study of Ultrasound-Guided Fine Needle Aspiration Cytology in Various Intraabdominal and Pelvic Lumps With Histopathological Correlation

Role of Usg Guided Fnac in Diagnosis of Intra-Abdominal and Intrapelvic Masses.

Comparative analysis of CD4 and CD8 lymphocytes — evidences for different distribution in primary and secondary liver tumors

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