Pathology of reversed passive Arthus reaction in the chicken

Abstract

SUMMARYSequential study of gross and microscopic changes in the chicken skin revealed that it was possible to induce a reversed passive Arthus reaction in 14-to 20-week-old chickens, using bovine serum albumin and antibovine serum albumin. However, high doses of immune reactants were required to elicit lesions of optimal intensity.

Pathology of passive mesenteric anaphylaxis in the chicken

“…Mixed cellular responses have even been reported in non-immunological inflammation (Carlson and Allen, 1970;Nair, 1973;Awadhiya et al, 1981a, b;Sinha et al, 1987). The present finding endorses the earlier suggestion made by Dhodapkar et al (1983Dhodapkar et al ( , 1984 that early emigration of heterophils and monocytoid cells, and participation of basophils, appear characteristic of acute inflammatory reaction in the chicken.…”

“…The exudate formed at 30 min had a mixed population of heterophils, monocytes and basophils. A similar mixed exudate has been reported by Chand et al (1976) in PCA and by Dhodapkar et al (1983Dhodapkar et al ( , 1984 in the Arthus reaction. Mixed cellular responses have even been reported in non-immunological inflammation (Carlson and Allen, 1970;Nair, 1973;Awadhiya et al, 1981a, b;Sinha et al, 1987).…”

“…Interestingly, emigration of basophils in significant numbers in PMA was noticed as early as 30 min in contrast to other types of injuries (Nair, 1973;Awadhiya et al, 1980aAwadhiya et al, , 1981bDhodapkar et al, 1984). This early participation of basophils and marked disappearance of their cytoplasmic granules suggest that basophils may in fact be playing a specific role in the chemical mediation of the anaphylactic reaction.…”

“…Similar observation has been reported in PCA in the chicken by Chand et al (1976) who also postulated release of some other leucotactic factors (perhaps a basophil chemotactic factor(s) at the site of antigen-antibody reaction. Dhodapkar et al (1982Dhodapkar et al ( , 1984 reported phagocytosis of carbon by basophils in Arthus reaction in the chicken. This property of basophils has again been demonstrated.…”

The avian inflammatory‐reparative response: Adaptation and utilization of a tissue cage model

“…The pieces were dehydrated in acetone, cleared in benzene and embedded in paraffin. Sections were cut at 5 /mi thickness, and stained with haematoxylin and eosin, and also with 0.5% solution of toluidine blue in acetate buffer (pH 3.8) for 72 h for basophils/mast cells (Dhodapkar, et al, 1984). The tissue leukocytosis was assessed quantitatively (Katiyar et al, 1992).…”