Pathology of small cerebral arteries demonstrated by MRI: a marker of aging?

Cottier, Jean-Philippe; Edjlali, Myriam; Gaillard, Marie-Agnès; Domengie, F.; Aljishi, Ali N.; Casals, Xavier García; Herbreteau, Denis; Hommet, Caroline

doi:10.1684/pnv.2011.0301

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“…Several hypotheses have been advanced to explain these links. First, the reduction of the plasticity of the vessels irrigating white matter is responsible of a hypo-infusion, insufficient to create an infarction but capable of damaging the parenchyma [7][8][9], which could lead to a frontal subcortical dysfunction [1]. These anomalies associated with striato-frontal aging (leading to cognitive disorders) and psychosocial factors are responsible for a depressive vulnerability [10].…”

Section: Discussion:-mentioning

confidence: 99%

Leukoaraiosis and Depression: Links Between the Radiological Entity and the Depressive Symptomatology.

Kaddaf¹,

Otheman²,

Alaoui³

et al. 2018

IJAR

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Leukoaraiosis is a purely descriptive term for a radiological image, which describe confluent white matter abnormalities, detected by computed tomography (CT) or magnetic resonance imaging (MRI). The clinical presentation of this entity is heterogeneous and mostly severe. The relationship between Leukoaraiosis and depressive symptomatology is not yet completely understood. Ischemia seems to be the main favoring factor. Leukoaraiosis may be a risk factor for the onset, persistence, or worsening of depressive symptomatology in the elderly. Through a clinical case, we will address the different clinical and therapeutic aspects of this relationship.

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Section: Discussion:-mentioning

confidence: 99%