Pathology of the digestive tract and liver with COVID-19

Яковенко, Э. П.; Яковенко, А В; Ivanov, Andranik; Агафонова, Н. А.

doi:10.31146/1682-8658-ecg-176-4-19-23

Cited by 5 publications

(1 citation statement)

References 33 publications

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“…While gaining experience in the diagnosis and treatment of the new coronavirus disease (COVID-19), an increasing number of researchers are focusing on the extremely high prevalence of extrapulmonary symptoms, including gastroenterological manifestations in patients with COVID-19[ 1 ]. The frequency of gastrointestinal (GI) symptoms in patients with COVID-19 is variable and depends on the severity of the disease and, probably, the viral strain that causes the disease[ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Hepatobiliary system and intestinal injury in new coronavirus infection (COVID-19): A retrospective study

Козлов¹,

Жданов²,

Ratnikova³

et al. 2023

World J Clin Cases

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BACKGROUND An important area of effective control of the coronavirus disease 19 (COVID-19) pandemic is the study of the pathogenic features of severe acute respiratory syndrome coronavirus 2 infection, including those based on assessing the state of the intestinal microbiota and permeability. AIM To study the clinical features of the new COVID-19 in patients with mild and moderate severity at the stage of hospitalization, to determine the role of hepatobiliary injury, intestinal permeability disorders, and changes in the qualitative and quantitative composition of the microbiota in the development of systemic inflammation in patients with COVID-19. METHODS The study was performed in 80 patients with COVID-19, with an average age of 45 years, 19 of whom had mild disease, and 61 had moderate disease severity. The scope of the examination included traditional clinical, laboratory, biochemical, instrumental, and radiation studies, as well as original methods for studying microbiota and intestinal permeability. RESULTS The clinical course of COVID-19 was studied, and the clinical and biochemical features, manifestations of systemic inflammation, and intestinal microbiome changes in patients with mild and moderate severity were identified. Intestinal permeability characteristics against the background of COVID-19 were evaluated by measuring levels of proinflammatory cytokines, insulin, faecal calprotectin, and zonulin. CONCLUSION This study highlights the role of intestinal permeability and microbiota as the main drivers of gastroenterological manifestations and increased COVID-19 severity.

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Section: Introductionmentioning

confidence: 99%

Hepatobiliary system and intestinal injury in new coronavirus infection (COVID-19): A retrospective study

Козлов¹,

Жданов²,

Ratnikova³

et al. 2023

World J Clin Cases

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Hyperammonemia is a risk factor for poor outcomes in patients with COVID-19

Tarasova,

Malyavin,

Busalaeva

et al. 2022

Dok. gastroenterol.

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Microbiota and intestinal permeability as drivers of gastroenterological manifestations of new coronavirus infection (COVID-19)

Козлов

Ratnikova²,

Гриневич

et al. 2021

jour

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An important area of effective control of the COVID-19 pandemic is the study of the pathogenetic features of SARSCoV-2 infection, including those based on the assessment of the state of the microbiota and intestinal permeability.Purpose: To study the clinical features of the new coronavirus infection (COVID-19) in patients of mild and moderate severity at the stage of hospitalization, to determine the role of intestinal permeability disorders, changes in the qualitative and quantitative composition of the microbiota in the formation of systemic inflammation in COVID-19 patients.Material and methods: The study was performed in 80 patients with COVID-19, whose average age was 45 years, 19 of them had mild and 61 had moderate severity of the disease. The scope of the examination included traditional clinical, clinical and laboratory, biochemical, instrumental and radiation studies, as well as original methods for studying microbiota and intestinal permeability.Results and conclusions: Clinical features of the course of COVID-19 were studied, clinical and biochemical features, manifestations of systemic inflammation, changes in the intestinal microbiome of patients with mild and moderate severity were identified, concentration levels of proinflammatory cytokines, insulin, fecal calprotectin and zonulin were determined, reflecting the features of intestinal permeability against the background of COVID-19. The role of intestinal permeability and microbiota as the main drivers of the development of gastroenterological manifestations of COVID-19, accompanied by a more severe course of the disease, is emphasized.

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Pathology of the digestive tract and liver with COVID-19

Cited by 5 publications

References 33 publications

Hepatobiliary system and intestinal injury in new coronavirus infection (COVID-19): A retrospective study

Hepatobiliary system and intestinal injury in new coronavirus infection (COVID-19): A retrospective study

Hyperammonemia is a risk factor for poor outcomes in patients with COVID-19

Microbiota and intestinal permeability as drivers of gastroenterological manifestations of new coronavirus infection (COVID-19)

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