Pathology of the Patella

Vigorita, Vincent J.; Morgan, Daniel L.

doi:10.1007/978-1-4612-4188-1_4

Cited by 6 publications

(7 citation statements)

References 23 publications

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“…Sex-specific agerelated changes in the knee joint have been documented for cartilage morphology [18,19] and may be indicative of a gender-specific susceptibility to degenerative joint disease. Studies on osteoarthritis in the knee show that new bone forms at the margins of the articular cartilage [20]. This process may be responsible for a slight increase in patellar dimensions and thus explain the greater propensity of female specimen to be misclassified-particularly at higher ages.…”

Section: Resultsmentioning

confidence: 98%

Sex determination by discriminant analysis: an evaluation of the reliability of patella measurements

Kemkes-Grottenthaler

2005

Forensic Science International

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Section: Resultsmentioning

confidence: 98%

Sex determination by discriminant analysis: an evaluation of the reliability of patella measurements

Kemkes-Grottenthaler

2005

Forensic Science International

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“…Key words: articular cartilage, elbow, matrix metalloproteinase, osteochondritis dissecans, subchondral bone, TUNEL assay Osteochondritis dissecans (OCD) of the elbow is a localized condition involving the articular cartilage on the subchondral bone, which results in the separation of a segment of cartilage and bone. [1][2][3][4][5] This disorder is found mainly in teenage athletes in sports involving throwing. 6,7 The most common site for the OCD of the elbow is the capitellum, and the lesion is most often located at a central or anterolateral position.…”

Section: Osteochondritis Dissecans (Ocd) Of the Elbow Is A Localized mentioning

confidence: 99%

Osteochondritis dissecans of the elbow: Histopathological assessment of the articular cartilage and subchondral bone with emphasis on their damage and repair

Kusumi¹,

Ishibashi

Tsuda

et al. 2006

Pathology International

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Osteochondritis dissecans (OCD) of the elbow is a localized injury of the articular cartilage and subchondral bone that is commonly seen in the young athlete. In the present study, the extent of damage and repair on the articular cartilage and subchondral bone was examined histologically using specimens of 25 osteochondral cylinders and seven loose bodies obtained from 25 young athletes who had undergone osteochondral autograft surgery. Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling (TUNEL) assays for detecting apoptotic cells and immunohistochemistry of matrix metalloproteinases (MMP) were performed on the osteochondral cylinder specimens. The histological findings of the OCD of the elbow showed that the articular cartilage exhibited degenerative change, mimicking osteoarthritis, and was markedly damaged as the lesion progressed. TUNEL-positive cells and MMP-3- and -13-expressing cells were distributed in the degenerative articular cartilage and reparative fibrocartilage tissue. Separation occurred at either the deep articular cartilage or the subchondral bone, with the former being dominant in the early OCD lesions. The present results suggest that the primary pathological changes in OCD of the elbow were due to damage of articular cartilage induced by repeated stress following degenerative and reparative process of articular cartilage and subchondral fracturing, and separation subsequently occurred on the cartilage and developed onto the subchondral bone in its advanced stages.

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“…The outcome of bone healing can be affected by a diversity of local and systemic factors with varying degrees of affection including fracture gap and comminution, disturbances of blood flow, degree of soft tissue damage [9, 10], insufficient mechanical stability, [10–13], poor nutritional state, age, and smoking [14, 15]. Another important factor that can interfere with the body's ability to heal a fracture is the administration of several pharmacological agents [15].…”

Section: Introductionmentioning

confidence: 99%

Do Nonsteroidal Anti-Inflammatory Drugs Affect Bone Healing? A Critical Analysis

Pountos

Georgouli

Calori

et al. 2012

The Scientific World Journal

238

161

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Nonsteroidal anti-inflammatory drugs (NSAIDs) play an essential part in our approach to control pain in the posttraumatic setting. Over the last decades, several studies suggested that NSAIDs interfere with bone healing while others contradict these findings. Although their analgesic potency is well proven, clinicians remain puzzled over the potential safety issues. We have systematically reviewed the available literature, analyzing and presenting the available in vitro animal and clinical studies on this field. Our comprehensive review reveals the great diversity of the presented data in all groups of studies. Animal and in vitro studies present so conflicting data that even studies with identical parameters have opposing results. Basic science research defining the exact mechanism with which NSAIDs could interfere with bone cells and also the conduction of well-randomized prospective clinical trials are warranted. In the absence of robust clinical or scientific evidence, clinicians should treat NSAIDs as a risk factor for bone healing impairment, and their administration should be avoided in high-risk patients.

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Pathology of the Patella

Cited by 6 publications

References 23 publications

Sex determination by discriminant analysis: an evaluation of the reliability of patella measurements

Sex determination by discriminant analysis: an evaluation of the reliability of patella measurements

Osteochondritis dissecans of the elbow: Histopathological assessment of the articular cartilage and subchondral bone with emphasis on their damage and repair

Do Nonsteroidal Anti-Inflammatory Drugs Affect Bone Healing? A Critical Analysis

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