Pathology of tricuspid valve stenosis and pure tricuspid regurgitation—Part I

Abstract

Summary: This three-part article examines the histologic and morphologic basis for stenotic and purely regurgitant tricuspid valves.In Part 1, conditions producing tricuspid valve stenosis are reviewed. In over 90% of stenotic tricuspid valves, the etiology is rheumatic disease. In isolated tricuspid stenosis, the etiology is either carcinoid or congenital. Rare causes of tricuspid stenosis include active infective endocarditis, metabolic or enzymatic abnormalities (Fabry's, Whipple's disease), and giant blood cysts.

2008 Focused Update Incorporated Into the ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease

“…On very rare occasions, infective endocarditis (with large bulky vegetations), congenital abnormalities, carcinoid, Fabry's disease, Whipple's disease, or previous methysergide therapy may be implicated (664). Right atrial mass lesions represent a nonvalvular cause of obstruction to the tricuspid orifice and may also over time destroy the leaflets and cause regurgitation.…”

ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease

“…Tricuspid stenosis is most commonly rheumatic in origin. On very rare occasions, infective endocarditis (with large bulky vegetations), congenital abnormalities, carcinoid, Fabry's disease, Whipple's disease, or previous methysergide therapy may be implicated (664). Right atrial mass lesions represent a nonvalvular cause of obstruction to the tricuspid orifice and may also over time destroy the leaflets and cause regurgitation.…”

2008 Focused Update Incorporated Into the ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease

“…On very rare occasions, infective endocarditis (with large bulky vegetations), congenital abnormalities, carcinoid, Fabry's disease, Whipple's disease, or previous methysergide therapy may be implicated. 664 Right atrial mass lesions represent a nonvalvular cause of obstruction to the tricuspid orifice and may also over time destroy the leaflets and cause regurgitation. Rheumatic tricuspid involvement usually results in both stenosis and regurgitation.…”