Pathology of Tumours of the Nervous System (4th edition)

Russell, Dorothy S.; Rubinstein, Lucicn J.

doi:10.1097/00000478-197803000-00013

Cited by 213 publications

(282 citation statements)

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“…Cancer registry studies are dependent on the rate of notification, which is very high in Denmark (Clemmesen, 1965), but influenced by different coding practices (Clemmesen, 1965;Schoenberg et al, 1976) or, in big countries, by different neuropathological judgements of tumour type (Ziilch, 1971;Russell and Rubinstein, 1977). The neuropathological definition is almost uniform in Denmark, and the differences in histological typing between the neuropathological centres are small and insignificant, as is clear from an earlier study from the eastern part of Denmark (Gjerris et al, 1976).…”

Section: Discussionmentioning

confidence: 99%

Incidence and long term survival of children with intracranial tumours treated in Denmark 1935-1959

Gjerris¹,

Harmsen²,

Klinken³

et al. 1978

Br J Cancer

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Summary.-The total number of children under 15 years of age with intracranial tumours in Denmark during the years 1935-1959 was found to be 533. The average incidence was 21 new cases/106 children/year during the 25-year period in question, and 25/106 children/year during the first 17 years of Danish cancer registration. The sex ratio (290 boys to 243 girls) was not significantly different from that of the child population in Denmark. In 219 cases the tumour was located in the supratentorial and in 314 in the infratentorial space. 9300 of the tumours were histologically verified, with the following order of frequency for the most usual types: astrocytomas (all grades), medulloblastomas, ependymomas, and craniopharyngiomas. Follow-up was 1000%. For the 345 children who survived for more than one month after operation or diagnosis, 36% were alive after 15 years. 119 patients were alive in April 1974 and these were all observed between 15-40 years after diagnosis and operation. Of these 44 had tumours in the supratentorial and 75 in the infratentorial space. 660/" of the survivors with supratentorial and 9000 with infratentorial tumours led a normal life.Most of the survivors had had a cerebellar astrocytoma, a supratentorial astrocytoma, an apendymoma or oligodendroglioma, but other histological diagnoses were also represented, especially in the supratentorial group. The long-term prognosis was especially bad for children with brain-stem tumours, infratentorial ependymomas and medulloblastomas.

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Section: Discussionmentioning

confidence: 99%

Incidence and long term survival of children with intracranial tumours treated in Denmark 1935-1959

Gjerris¹,

Harmsen²,

Klinken³

et al. 1978

Br J Cancer

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“…Both types of tissue often coexist in the same tumour and the latter does not necessarily predominate. 14 Heterogeneity in MRI signal intensity is due to the diversity of morphology, which may include intratumoural cysts, areas of different cellular patterns, calcifications, and regions of haemorrahage. 15 Moreover, pathological characteristics frequently vary across different regions of the same tumour.…”

Section: Eyementioning

confidence: 99%

Orbital schwannomas: findings from magnetic resonance imaging in 62 cases

Wang

Xiao

2007

Eye

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Purpose To evaluate the diagnostic value of magnetic resonance imaging (MRI) and illustrate the common MRI features of orbital schwannoma. Methods We reviewed 62 consecutive cases of pathologically proven orbital schwannoma investigated by MRI. All cases were examined using T1-and T2-weighted images. Enhanced T1-weighted images were obtained after administration of gadopentetate dimeglumine. The images were analysed and compared. Results Cone-shaped lesions were the most frequent (16, 26%), followed by dumbbell-shaped (10, 16%), oval (9, 15%) and round lesions (8, 13%). The most common site was the superior aspect of the orbit (17, 27%), followed by the medial superior (12, 19%) and the orbital apex (12, 19%). On unenhanced T1-weighted images, 53 (85%) lesions showed isointensity or small patches of hypointensity. The patterns of enhancement seen on T1-weighted images correlated with the signal characteristics of unenhanced T2-weighted images. Five patterns emerged in our series. Among these patterns, the most common sign, found in 18 (29%) cases, was peripheral (ring) enhancement on enhanced T1-weighted images, which showed peripheral isointensity with central hyperintensity on T2-weighted images. Lesions with homogeneous or heterogeneous enhancement were seen in 16 (26%) and 26 (42%) cases, respectively. Conclusions MRI is a valuable diagnostic method for orbital schwannoma, particularly when contrast is applied. The locations and shapes of tumours can be seen distinctly. T1-weighted images are relatively nonspecific. T2-weighted and enhanced T1-weighted images provide information about the pathology of tumours. In particular, peripheral enhancement should be considered a target sign of schwannoma.

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“…However, rare cases of meningeal tumor have also been described and a derivation from the mesenchymal cells of the meninges cannot be rule out [8].…”

Section: Discussionmentioning

confidence: 99%

“…In this latter localization, they arise from the mesenchymal elements of the brain and its coverings but also from cranial bones [4][5][6][7][8]. They present either as the sole or minor component of a primary tumor or as a metastasis of a distant extracranial angiosarcoma [3,[7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Primary temporal bone angiosarcoma: a case report

et al. 2005

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SummaryWe present a rare case of temporal bone angiosarcoma diagnosed in a 26-year-old female patient at 36 week of pregnancy. The patient was referred with a 2 months history of left otalgia and tinnitus with a tender swelling above the mastoid. Cranial imaging studies showed a 7 × 5 × 4 cm hypervascularized mass located in the left middle fossa with lysis of the temporal bone and extension to the subcutis. After the baby was delivered by caesarean section, the patient entered the oncology protocol. Selective embolization of the feeding vessels was followed by gross total surgical resection using a combined supra-and infra-tentorial approach. Pathological findings were those of a poorly differentiated, highly malignant sarcoma with a large epitheloid component and immunohistochemical evidence of endothelial differentiation (CD31, Factor VIII related antigen, CD34), consistent with an angiosarcoma with epitheloid features. No extra-cranial tumor was found after extensive staging. The patient received adjuvant radiotherapy followed by a course of chemotherapy consisting of 6 cycles of paclitaxel. At 15 months follow-up, she developed multiple distant metastasis to a left postauricular lymph node and to the lungs and ribs. The patient was given a second line chemotherapy using doxorubicine and ifosfamide. Despite an initial good response, she died with metastatic disease 26 months after diagnosis. We present a rare case of primary temporal bone angiosarcoma and report our experience with a multimode therapeutic approach combining surgery, radiotherapy and chemotherapy.

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Pathology of Tumours of the Nervous System (4th edition)

Cited by 213 publications

References 0 publications

Incidence and long term survival of children with intracranial tumours treated in Denmark 1935-1959

Incidence and long term survival of children with intracranial tumours treated in Denmark 1935-1959

Orbital schwannomas: findings from magnetic resonance imaging in 62 cases

Primary temporal bone angiosarcoma: a case report

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