Pathology Quiz Case

Waldman, Erik H.; DeSantis, Emily; Lustig, Lawrence R.; Tunkel, David E.

doi:10.1001/archotol.131.4.363

Cited by 2 publications

(1 citation statement)

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“…Гетеротопия нейроглиальной ткани в области головы чаще встречается по средней линии, реже -латеральнее средней линии [22,[27][28][29][30][31]. Гистологически глиальная хористома состоит из нейронов и глиальной ткани с сопутствующим хроническим воспалением и глиозом [12,24,[32][33][34][35][36].…”

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Choristoma of Internal Auditory Canal: Literature Review

Diab¹,

Дайхес²,

Saidulaev³

et al. 2022

Оториноларингология. Восточная Европа

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Хористомы внутреннего слухового прохода являются чрезвычайно редкими опухолями. Из-за их редкости и отсутствия характерной клинической и рентгенологической картины их обычно ошибочно диагностируют как вестибулярные шванномы. Единственным методом дифференциальной диагностики хористомы от шванномы является патогистологическое исследование удаленной опухоли, при котором обнаруживают нервные волокна, гладкую мышечную ткань и небольшое количество жировой ткани. Опухоль вовлекает в патологический процесс кохлеовестибулярный и лицевой нервы и обычно интимно спаяна с ними, что представляет серьезную проблему для хирурга. Именно поэтому нет единого мнения относительно тактики лечения данной категории пациентов. Choristomas of the internal auditory canal are extremely rare tumors. Due to their rarity and lack of specific clinical and radiological signs, it is usually misdiagnosed as vestibular schwannomas. The only method of differential diagnosis of choristoma and schwannoma is pathohistological examination of the resected tumor. Pathohistological examination of the tumor shows nerve fibers, smooth muscle tissue and a small amount of adipose tissue. The tumor involves the cochleovestibular and facial nerves in pathological process and is usually intimately soldered to them, which is a serious problem for the surgeon. That is why there is no consensus on the tactics of treatment of this category of patients.

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Choristoma of Internal Auditory Canal: Literature Review

Diab¹,

Дайхес²,

Saidulaev³

et al. 2022

Оториноларингология. Восточная Европа

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Neuroglial heterotopia of the middle ear: A case series and systematic literature review

Ahrendsen

Moore

Varma

2021

Surgical Neurology International

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Background: The differential diagnosis for mass forming lesions of the middle ear is broad. While uncommon, neuroglial heterotopias can occur in the middle ear and can be a source of diagnostic confusion for clinician, radiologist, and pathologist alike. Methods: We identified three cases of neuroglial heterotopia of the middle ear in our institutional archives from 2000 to 2020 and performed extensive histological and immunohistochemical characterization of the three lesions. We conducted a systematic literature review to identify 27 cases published in the English literature between the years 1980 and 2020. Only cases with histological verification of neuroglial heterotopia specifically involving the middle ear were included. We compiled the clinical, radiological, and histopathological findings for all 30 cases. Results: Patients most frequently presented with chronic otitis media (40%), hearing loss (40%), or prior history of ear surgery or trauma (13%). The median age at surgery was 49 years with a male predominance (M:F 2:1); however, a bimodal age distribution was noted with an earlier onset (11 years or younger) in a subset of patients. Immunohistochemical characterization showed mature neuronal and reactive glial populations with low Ki67 proliferation index and chronic inflammatory infiltrates. There was no neuronal dysplasia or glial atypia, consistent with benign, nonneoplastic, mature glioneuronal tissue. Conclusion: Immunohistochemical characterization of these lesions and clinical follow-up confirms their benign natural history. Potential etiologies include developmental misplacement, trauma, and chronic inflammation/ reactive changes resulting in sequestered encephalocele.

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Pathology Quiz Case

Cited by 2 publications

References 0 publications

Choristoma of Internal Auditory Canal: Literature Review

Choristoma of Internal Auditory Canal: Literature Review

Neuroglial heterotopia of the middle ear: A case series and systematic literature review

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