Pathomechanism of insulin resistance in chronic hepatitis C

Kukla, Michał; Sawczyn, Tomasz; Żwirska-Korczala, K; M, Jarosz

doi:10.5114/pg.2011.25376

Cited by 1 publication

(1 citation statement)

References 48 publications

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“…Chronic hepatitis C (CHC), because of concomitant insulin resistance (IR) [6,7], high prevalence of steatosis [8,9], increased prevalence of impaired glucose tolerance and/or type 2 diabetes mellitus (T2DM) [10,11,12] and changes in lipid metabolism [13], has been considered not only as a viral disease, but also as a metabolic liver disease. Moreover, IR is a strong predictor of poor response to antiviral therapy, alongside advanced hepatic steatosis and fibrosis [6,14].…”

Section: Introductionmentioning

confidence: 99%

Omentin serum concentration and hepatic expression in chronic hepatitis C patients – together or apart?

Kukla¹,

Waluga²,

Adamek³

et al. 2015

pjp

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Chronic hepatitis C (CHC) is accompanied by numerous metabolic disorders, partially associated with altered adipokine system regulation. Omentin (intelectin-1) is a novel adipokine known to play a pivotal role in metabolic regulation in CHC. In a group of 63 CHC patients (29 men/34 women) infected with genotype 1b, aged 6.6 ±14.6 years, serum omentin levels and its gene expression in liver tissue were examined and their association with metabolic and histopathological features was assessed. Serum omentin levels were significantly higher in CHC patients compared to controls (p < 0.001), regardless of sex, body mass index (BMI), insulin sensitivity and lipid concentrations. There was no correlation between serum omentin and omentin hepatic expression. Neither parameter was associated with any histological features. Serum omentin in non-obese CHC patients seems not to be related to metabolic disorders or liver pathology. Omentin hepatic expression shows no relationship with either serum omentin levels or histopathological features. This suggests different mechanisms regulating circulating omentin concentration and omentin hepatic expression in CHC.

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