Pathomechanism of Interstitial Cystitis/Bladder Pain Syndrome and Mapping the Heterogeneity of Disease

Jhang, Jia‐Fong; Kuo, Hann‐Chorng

doi:10.5213/inj.1632712.356

Cited by 76 publications

(77 citation statements)

References 102 publications

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“…Interstitial cystitis/bladder pain syndrome (IC/BPS), is a disease condition characterized by bladder pain, frequent urination, urgency, and nocturia . There have been many reports concerning the pathophysiology of IC/BPS including uroepithelial dysfunction, mast cell activation, neurogenic inflammation, but the accurate etiology remains unclear.…”

Section: Introductionmentioning

confidence: 99%

The effect of herpes simplex virus vector‐mediated gene therapy of protein phosphatase 1α on bladder overactivity and nociception

Majima

Mori

Kadekawa

et al. 2018

Neurourology and Urodynamics

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Aims We studied the effect of herpes simplex virus (HSV) vectors‐based gene transfer of protein phosphatase 1α (PP1α) on bladder hypersensitivity in rats. Methods Using adult female Sprague‐Dawley rats, non‐replicating HSV vectors carrying PP1α or green fluorescent protein (GFP) were injected into the bladder wall. At one week after vector inoculation, cystometry and Western blot assay were performed, whereas the other experiments were performed at 2 weeks after vector inoculation. Results GFP‐expressing cells were identified in the bladder as well as in L6/S1 dorsal root ganglia at 14 days. In cystometry, intercontraction intervals (ICI) after resiniferatoxin (RTx; TRPV1 agonist) irrigation was significantly reduced in the PP1α group in comparison with the GFP group. Moreover, RTx‐induced freezing behavior events were observed significantly more frequently in the PP1α group than the GFP group. The number of c‐Fos positive cells in the L6 spinal dorsal horn was significantly less in the PP1α group than in the GFP group. Western blot assay revealed lower levels of phosphorylated inositol 1, 4, 5‐triphosphate receptor (p‐IP3R), and phosphorylated TRPV1 in the PP1α compared with the GFP group. Conclusions HSV vectors‐mediated PP1α gene therapy may be an alternative treatment modality for cystitis‐related hypersensitive bladder condition at least in part via modulation of the IP3R signaling pathway.

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Section: Introductionmentioning

confidence: 99%

The effect of herpes simplex virus vector‐mediated gene therapy of protein phosphatase 1α on bladder overactivity and nociception

Majima

Mori

Kadekawa

et al. 2018

Neurourology and Urodynamics

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“…Причины развития СБМП до конца не-ясны. В качестве возможных причин его развития рассматривают уротелиальные дисфункции, акти-вацию тучных клеток, аутоиммунные, нейрогенные и ишемические нарушения, инфекционное воспа-ление [5][6][7]. В основе диагностики СБМП лежит оценка симптоматики заболевания, результатов цистоскопии и биопсии стенки мочевого пузыря при обязательном исключении других возможных причин появления боли и расстройств мочеиспу-скания [8][9][10].…”

Section: Introductionunclassified

Use of the russian version of pelvic pain and urgency/frequency patient symptom scale (PUF scale) in patients with the bladder pain syndrome

et al. 2017

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Introduction. Increasing the effectiveness of diagnostic and treatment of patients with the bladder pain syndrome (BPS) is an actual problem of the current urology. Assessment of clinical manifestations of the disease is carried out using special questionnaires. One of the most commonly used of that is the Pelvic Pain and Urgency/Frequency Patient Symptom Scale (PUF Scale). Purpose of the study. Evaluate the validity of the Russian-language version of the PUF questionnaire in patients with BPS. Materials and methods. The main group consisted of 40 patients with BPS (5 men and 35 women). The control group consisted of 50 conditionally healthy volunteers (16 men and 34 women). All participants in the study filled out the diary of the urination and the PUF Scale questionnaire twice with an interval of 2 weeks. For patients with BPS was performed cystoscopy with hydrodistension of the bladder. Results. In patients with BPS the total mean score for the PUF Scale questionnaire was 25.3 ± 6.9, with an average urinary symptom score of 14.7 ± 4.5 and an average discomfort score of 8.7 ± 2.5. The difference between the values of all three indices in the main and control groups was significantly different (p < 0.001). A high degree of internal consistency of the questions of the PUF Scale questionnaire (coefficient of Cronbach alpha 0.961) is shown. The sum of the PUF Scale questionnaire correlated with the clinical manifestations of BPS as well as the presence of Hunner’s bladder lesions (p = 0.024) and bladder capacity in hydrodistension (p = 0.001). Conclusion. The PUF Scale questionnaire is a reliable method for assessing the severity of symptomatology of BPS. The results of the questionnaire correlate with the severity of clinical manifestations of the disease, as well as with cystoscopy data. (For citation: Al-Shukri SKh, Kuzmin IV, Slesarevskaya MN, et al. Use of the russian version of pelvic pain and urgency/frequency patient symptom scale (PUF scale) in patients with the bladder pain syndrome. Urologicheskie vedomosti. 2017;7(2):5-9. doi: 10.17816/uroved725-9).

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“…24 Heredity might play a role in the pathogenesis of BPS. In 2004 study found that prevalence of BPS in females who have a first-degree relative with confirmed BPS is 1,431 per 100,000.5 In comparison, the prevalence rate in the general population is estimated to be about 60 per 100,000.…”

Section: Risk Factorsmentioning

confidence: 99%

Bladder pain syndrome from urogynecological point of view: a narrative

Shebl

Dawood

2017

Int J Reprod Contracept Obstet Gynecol

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Hypothesis: bladder pain syndrome (BPS) presents by both urological and gynecological symptoms. The gynecological symptoms include chronic persistent pelvic pain, dyspareunia and decreased libido on the other hand urological symptoms include wide variety of symptoms as bladder discomfort, dysuria, frequency, and urgency. Although, the definition and diagnostic criteria for the condition was established, the pathogenesis, etiology and histologic findings of BPS are still not fully understood and diagnosis is made by exclusion. Review of published data including both gynecological and urological articles focusing on the updates in the diagnostic tests, pathology and the recent therapies. The searched words were bladder pain syndrome, interstitial cystitis and painful bladder. The free full text article found after our search were 454 articles after exclusion of deficient article not covering the whole subject, 91 articles were enough for this work to be completed. From this review, Bladder pain syndrome is still unclear disease lacking curative therapy up till now and patients are still suffering and the mixed complex symptoms put further challenge on both urologists and gynecologists to solve the problem.

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Pathomechanism of Interstitial Cystitis/Bladder Pain Syndrome and Mapping the Heterogeneity of Disease

Cited by 76 publications

References 102 publications

The effect of herpes simplex virus vector‐mediated gene therapy of protein phosphatase 1α on bladder overactivity and nociception

The effect of herpes simplex virus vector‐mediated gene therapy of protein phosphatase 1α on bladder overactivity and nociception

Use of the russian version of pelvic pain and urgency/frequency patient symptom scale (PUF scale) in patients with the bladder pain syndrome

Bladder pain syndrome from urogynecological point of view: a narrative

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