Pathomorphosis of Uterine Myomas in Women

Madej, Paweł; Madej, Janusz A.

doi:10.2174/1874375700802010019

Cited by 3 publications

(4 citation statements)

References 20 publications

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“…Leiomyoma uteri is the commonest benign tumour of the female genital tract including the uterine body [11]. This perhaps makes it the first diagnostic consideration the clinician made when evaluating pelvic masses in young female adults.…”

Section: Discussionmentioning

confidence: 99%

Pelvic Desmoid Tumour Imitating Uterine Leiomyoma in a Nigerian Premenopausal Woman

Ajani¹,

Ngubor²,

Nkwogu³

et al. 2020

JAMMR

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Aim: To describe a rare case of pelvic desmoid tumour simulating as a huge uterine leiomyoma causing a diagnostic dilemma in a premenopausal woman. Case Presentation: This was a 44-year-old, para 2 (2 alive) who was referred to our gynaecology clinic from a secondary health facility on account of slowly increasing abdominal swelling of 2 years duration. There was no nausea, vomiting or diarrhoea. There was associated mild to moderate dull lower abdominal pain that did not radiate to any other part of the body. There was no change in her monthly menstrual flow. Physical examination revealed a pelvic mass about 32 weeks pregnancy size and firm. Computed Topography scan showed a huge pedunculated sub-serous uterine fibroid. A huge mass adherent to the anterior surface of the body of the uterus was completely surgically excised at exploratory laparotomy. Histology of the excised tumour revealed a definitive histological diagnosis of pelvic desmoid tumour. The patient was clinically stable and discharged home 10 days post operation and was followed-up on out-patient gynaecology clinic basis. Discussion: Pelvic desmoid is a rare mesenchymal tumour caused by abnormal proliferation of fibroblasts. It is three times more common in women and occurs mostly between 25 and 35 years of age which correspond to the same age peak incidence for uterine fibroids. The tumour can easily be misdiagnosed as uterine leiomyoma and imaging cannot reliably distinguish the two conditions. Conclusion: Pelvic desmoid tumour should be considered as a differential diagnosis in premenopausal women who present with abdominal swelling. Relevant clinical history, Radiological imaging and Histopathological assessment are essential in making prompt accurate diagnosis.

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Section: Discussionmentioning

confidence: 99%

Pelvic Desmoid Tumour Imitating Uterine Leiomyoma in a Nigerian Premenopausal Woman

Ajani¹,

Ngubor²,

Nkwogu³

et al. 2020

JAMMR

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“…This is why MT could be considered as a marker of endometriosis. 18 The perinuclear location of MT is known to be important for protection against DNA damage and apoptosis induced by external stressors. 27 Therefore, the MT expression in endometrial cells could favor their persistence in ectopic localization, as reported by Wicherek et al (2006).…”

Section: Discussionmentioning

confidence: 99%

“…1 Several theories have been proposed, such as the presence of retrograde menstrual flow associated with an immunological predisposition in the peritoneal microenvironment that facilitates the implantation of viable endometrial cells and has the potential for implantation. 2 Recent studies suggest that the endometria of patients with endometriosis have an invasive and aggressive behavior, and higher expression levels of substances related to cellular invasion, cellular differentiation, and proliferation, such as metalloproteases (MMPs) and tissue inhibitors of MMPs (TIMPs), [3][4][5][6][7][8][9][10][11] p63, [12][13][14][15][16] and metallothionein (MT) [17][18][19] have been described.…”

Section: Introductionmentioning

confidence: 99%

Increased Expression Levels of Metalloprotease, Tissue Inhibitor of Metalloprotease, Metallothionein, and p63 in Ectopic Endometrium: An Animal Experimental Study

Brandão

Meola

Garcia

et al. 2018

Rev Bras Ginecol Obstet

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Objective To characterize the patterns of cell differentiation, proliferation, and tissue invasion in eutopic and ectopic endometrium of rabbits with induced endometriotic lesions via a well- known experimental model, 4 and 8 weeks after the endometrial implantation procedure. Methods Twenty-nine female New Zealand rabbits underwent laparotomy for endometriosis induction through the resection of one uterine horn, isolation of the endometrium, and fixation of tissue segment to the pelvic peritoneum. Two groups of animals (one with 14 animals, and the other with15) were sacrificed 4 and 8 weeks after endometriosis induction. The lesion was excised along with the opposite uterine horn for endometrial gland and stroma determination. Immunohistochemical reactions were performed in eutopic and ectopic endometrial tissues for analysis of the following markers: metalloprotease (MMP-9) and tissue inhibitor of metalloprotease (TIMP-2), which are involved in the invasive capacity of the endometrial tissue; and metallothionein (MT) and p63, which are involved in cell differentiation and proliferation. Results The intensity of the immunostaining for MMP9, TIMP-2, MT, and p63 was higher in ectopic endometria than in eutopic endometria. However, when the ectopic lesions were compared at 4 and 8 weeks, no significant difference was observed, with the exception of the marker p63, which was more evident after 8 weeks of evolution of the ectopic endometrial tissue. Conclusion Ectopic endometrial lesions seem to express greater power for cell differentiation and tissue invasion, compared with eutopic endometria, demonstrating a potentially invasive, progressive, and heterogeneous presentation of endometriosis.

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“…It is a benign non-epithelial, mesenchymal monoclonal tumor of smooth muscle cells and a framework of fibrous connective tissue [1, 2]. Uterine LC occurs with 5% frequency [3].…”

Section: Introductionmentioning

confidence: 99%

Leiomyoma and leiomyoma cellulare of the fallopian tube: review of the literature and case reports

Sikora-Szczęśniak¹

2016

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IntroductionLeiomyoma of the fallopian tube is extremely rare, and its version – leiomyoma cellulare (LC) of the fallopian tube is absolutely unique. Aim of the study was to review literature reports on leiomyomas of the fallopian tubes, and to present cases of leiomyoma and LC of the fallopian tubes in the patients operated on in our ward.Material and methodsThere were fewer than 100 cases of leiomyomas of the fallopian tubes discussed in the literature up to 1993. Case 1. Leiomyoma of the left fallopian tube was detected postoperatively in a 68-year-old patient, G.K., on histopathological examination after laparoscopic total hysterectomy with bilateral adnexa. Case 2. A 56-year-old patient, K.T., with LC of the fallopian tube was qualified for laparoscopy. At operation, the procedure was converted to microlaparotomy due to the tumor size. The adnexa on the right side with the tumor of the fallopian tube were excised, and the left fallopian tube was excised, too. Histopathological microscopy found leiomyoma cellulare partim epithelioides. ResultsIn the presented cases, the extent of operation was connected with the clinical picture, and in the case of LC of the right fallopian tube, with intraoperative histopathological findings. In both cases the postoperative course was uneventful.ConclusionsDiagnosis of leiomyoma and LC of the fallopian tube, like in the other organs of the female genital tract, is possible only due to results of histopathological microscopy.

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Pathomorphosis of Uterine Myomas in Women

Cited by 3 publications

References 20 publications

Pelvic Desmoid Tumour Imitating Uterine Leiomyoma in a Nigerian Premenopausal Woman

Pelvic Desmoid Tumour Imitating Uterine Leiomyoma in a Nigerian Premenopausal Woman

Increased Expression Levels of Metalloprotease, Tissue Inhibitor of Metalloprotease, Metallothionein, and p63 in Ectopic Endometrium: An Animal Experimental Study

Leiomyoma and leiomyoma cellulare of the fallopian tube: review of the literature and case reports

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