2006
DOI: 10.1016/j.pharmthera.2006.02.004
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Pathophysiologic and therapeutic implications of adrenomedullin in cardiovascular disorders

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Cited by 95 publications
(85 citation statements)
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References 200 publications
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“…Actions of adrenomedullin are generally protective to organs and tissues, from vasodilation, natriuresis, diuresis, to anti-inflammation (2). The receptors of ADM are a complex of receptor-activity modifying proteins (RAMP) and calcitonin receptor-like receptor (CRLR) (40).…”
Section: Discussionmentioning
confidence: 99%
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“…Actions of adrenomedullin are generally protective to organs and tissues, from vasodilation, natriuresis, diuresis, to anti-inflammation (2). The receptors of ADM are a complex of receptor-activity modifying proteins (RAMP) and calcitonin receptor-like receptor (CRLR) (40).…”
Section: Discussionmentioning
confidence: 99%
“…The receptors of ADM are a complex of receptor-activity modifying proteins (RAMP) and calcitonin receptor-like receptor (CRLR) (40). The mechanisms of action of ADM are thought so far to be through the generation of nitric oxide via nitric oxide-cyclic guanine monophosphate pathway or through increased intracellular cyclic adenosine monophosphate which activates protein kinase A which then activates nitric oxide synthase or through phosphatidylinositol kinase -3 activation and Akt phosphorylation resulting in enhanced stimulation of endothelial nitric oxide synthase (2,38).…”
Section: Discussionmentioning
confidence: 99%
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“…Adrenomedullin mediates its effects through its second messenger, cyclic adenosine mono-phosphate (cAMP), which, in turn, increases the production of nitric oxide (NO) [41]. Its role in cardiac failure is mostly to reduce the afterload and dilate the coronary vessels via its vasodilatory actions [42], but the exact role of adrenomedullin in causing cardiac dysfunction in cirrhosis is unclear. It is postulated that adrenomedullin may contribute to myocardial dysfunction in cirrhosis via the negative inotropic effect of NO (see the subsequent text).…”
Section: Serum Markersmentioning
confidence: 99%
“…Adrenomedullin exhibits protective effects on the heart and the vasculature [44]. The stable midregional part of its prohormone, MR-proADM, is elevated in various cardiovascular pathologies and has been shown to be strongly predictive of mortality in populations with cardiovascular disease, especially heart failure [45] but also AMI [46].…”
Section: Mid-regional Part Of the Prohormone Of Adrenomedullinmentioning
confidence: 99%