Pathophysiological and immunohistochemical analysis of pancreas after renal ischemia/reperfusion injury: protective role of melatonin*

Protective Effect of Melatonin for Renal Ischemia-Reperfusion Injury: A Systematic Review and Meta-Analysis

“…The duration of ischemia ranged from 25 to 75 min, then the reperfusion from 1 to 72 h. The sample size of a single group ranged between 5 and 12. The melatonin administration was < 10 mg/kg in eight studies (Kunduzova et al, 2003 ; Sahna et al, 2003 ; Kurcer et al, 2007b ; Fadillioglu et al, 2008 ; Cetin et al, 2014 ; Sehajpal et al, 2014 ; Yilmaz et al, 2015 ; Wang et al, 2020 ), 10 mg/kg in 16 studies (Sener et al, 2002 ; Rodríguez-Reynoso et al, 2004 ; Aktoz et al, 2007 ; Kurcer et al, 2007a ; Ersoz et al, 2009 ; Sinanoglu et al, 2012 ; Ahmadiasl et al, 2013 , 2014a , b ; Sezgin et al, 2013 ; Sehajpal et al, 2014 ; Oguz et al, 2015 ; Banaei et al, 2016a , b ; Souza et al, 2018 ; Shi et al, 2019 ), and > 10 mg/kg in eight studies (Hadj Ayed Tka et al, 2015 ; Yip et al, 2015 ; Chang et al, 2016 ; Chen et al, 2019a , b ; M El Agaty and Ibrahim Ahmed, 2020 ; Yang et al, 2020 ; Zahran et al, 2020 ). Most studies took melatonin intraperitoneal injection, except one with subcutaneous injection (Sener et al, 2002 ), one with intravenous injection (Kunduzova et al, 2003 ), and another one with oral administration (M El Agaty and Ibrahim Ahmed, 2020 ).…”

“…The melatonin administration was < 10 mg/kg in eight studies (Kunduzova et al, 2003 ; Sahna et al, 2003 ; Kurcer et al, 2007b ; Fadillioglu et al, 2008 ; Cetin et al, 2014 ; Sehajpal et al, 2014 ; Yilmaz et al, 2015 ; Wang et al, 2020 ), 10 mg/kg in 16 studies (Sener et al, 2002 ; Rodríguez-Reynoso et al, 2004 ; Aktoz et al, 2007 ; Kurcer et al, 2007a ; Ersoz et al, 2009 ; Sinanoglu et al, 2012 ; Ahmadiasl et al, 2013 , 2014a , b ; Sezgin et al, 2013 ; Sehajpal et al, 2014 ; Oguz et al, 2015 ; Banaei et al, 2016a , b ; Souza et al, 2018 ; Shi et al, 2019 ), and > 10 mg/kg in eight studies (Hadj Ayed Tka et al, 2015 ; Yip et al, 2015 ; Chang et al, 2016 ; Chen et al, 2019a , b ; M El Agaty and Ibrahim Ahmed, 2020 ; Yang et al, 2020 ; Zahran et al, 2020 ). Most studies took melatonin intraperitoneal injection, except one with subcutaneous injection (Sener et al, 2002 ), one with intravenous injection (Kunduzova et al, 2003 ), and another one with oral administration (M El Agaty and Ibrahim Ahmed, 2020 ). Single-dose administration was conducted in 18 studies (Sener et al, 2002 ; Kunduzova et al, 2003 ; Sahna et al, 2003 ; Rodríguez-Reynoso et al, 2004 ; Kurcer et al, 2007a ; Ersoz et al, 2009 ; Ahmadiasl et al, 2013 , 2014a , b ; Cetin et al, 2014 ; Sehajpal et al, 2014 ; Hadj Ayed Tka et al, 2015 ; Oguz et al, 2015 ; Banaei et al, 2016a , b ; Souza et al, 2018 ; Wang et al, 2020 ; Zahran et al, …”

“…Two hundred seventeen publications were identified after search. After removing duplicates and performing title and abstract screening, 35 papers were selected for full-text screening, and 31 met the inclusion criteria (Sener et al, 2002 ; Kunduzova et al, 2003 ; Sahna et al, 2003 ; Rodríguez-Reynoso et al, 2004 ; Aktoz et al, 2007 ; Kurcer et al, 2007a , b ; Fadillioglu et al, 2008 ; Ersoz et al, 2009 ; Sinanoglu et al, 2012 ; Ahmadiasl et al, 2013 , 2014a , b ; Sezgin et al, 2013 ; Cetin et al, 2014 ; Sehajpal et al, 2014 ; Hadj Ayed Tka et al, 2015 ; Oguz et al, 2015 ; Yilmaz et al, 2015 ; Yip et al, 2015 ; Banaei et al, 2016a , b ; Chang et al, 2016 ; Souza et al, 2018 ; Chen et al, 2019a , b ; Shi et al, 2019 ; M El Agaty and Ibrahim Ahmed, 2020 ; Wang et al, 2020 ; Yang et al, 2020 ; Zahran et al, 2020 ). Of the four publications excluded at the full-text level, two did not conduct renal I/R injury to AKI (Li et al, 2009 ; Zhu et al, 2017 ), and the other two used melatonin combined with other treatments (mesenchymal stem cell-derived exosomes, or nitric oxide synthase inhibitor) (Deniz et al, 2006 ; Alzahrani, 2019 ).…”

“…A unilateral nephrectomy was performed before contralateral renal I/R injury in 12 studies (Sener et al, 2002 ; Sahna et al, 2003 ; Rodríguez-Reynoso et al, 2004 ; Kurcer et al, 2007a ; Sinanoglu et al, 2012 ; Ahmadiasl et al, 2013 , 2014a , b ; Sezgin et al, 2013 ; Oguz et al, 2015 ; Banaei et al, 2016a , b ). Most of the studies conducted unilateral renal I/R injury, except 10 studies performed bilateral renal I/R injury (Ersoz et al, 2009 ; Sehajpal et al, 2014 ; Hadj Ayed Tka et al, 2015 ; Yip et al, 2015 ; Chen et al, 2019a , b ; Shi et al, 2019 ; M El Agaty and Ibrahim Ahmed, 2020 ; Wang et al, 2020 ; Zahran et al, 2020 ). The duration of ischemia ranged from 25 to 75 min, then the reperfusion from 1 to 72 h. The sample size of a single group ranged between 5 and 12.…”

Mechanisms of Melatonin in Obesity: A Review

“…The pancreas’s internal and external secretory function makes it crucial in regulating blood glucose, and digesting glucose and fat. Treatment with melatonin significantly mitigates pancreatic injury, including impairment of exocrine and endocrine pancreatic functions [ 100 ]. As mentioned above, melatonin affects the secretion of insulin by β cells, and it also affects glucagon secretion by α cells, with the involvement of melatonin’s modulation of PI3K, intracellular messengers like cAMP, cGMP, arachidonic acid, and calcium ions in various condition, and regulation of the glucagon promoter by melatonin-induced activation of phospholipase C (PLC) [ 57 ].…”