Pathophysiological aspects of neuro-endocrine regulation system in patients with obstructive sleep apnea syndrome

Мадаева, Ирина; Шолохов, Л. Ф.; Semenova, Natalya; Kolesnikova, L. I.

doi:10.17116/jnevro20181184255

Cited by 7 publications

(4 citation statements)

References 14 publications

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“…For plasma cortisol concentrations, we excluded one study with outlier data ( 53 ) but the pattern of results remained unchanged [MD = -0.89; 95% CI: -2.83, 1.06; P = 0.37; I 2 = 76% (P h = 0.002)]. For serum cortisol concentrations, we excluded two studies with outlier data ( 50 , 67 ); while the pattern of results remained unchanged [MD = -1.22; 95% CI: -2.74, 0.30; P = 0.12; I 2 = 0% (P h = 0.64)], heterogeneity decreased to 0%.…”

Section: Resultsmentioning

confidence: 99%

“…Five studies reported salivary cortisol concentrations (45,(47)(48)(49)70), five studies reported serum cortisol concentrations (50,65,(67)(68)(69), four reported plasma cortisol concentrations (53,56,64,66), and two reported both salivary and plasma cortisol concentrations (51,52). Ten studies were performed with Caucasians (45,47,50,52,56,(64)(65)(66)(67)69), four studies sampled Asians (48,49,53,68), and two studies sampled mixed ethnicities (51,70). Fourteen out of 16 studies assessed adult samples, the other two assessed pediatric samples (45,48).…”

Section: Resultsmentioning

confidence: 99%

“…The latter observation implies a lowered HPA AA in the longer term. In addition, there have also been inconsistent findings concerning the links between risk of OSAS and salivary ( 45 , 47 – 49 ), serum ( 46 , 50 ), and plasma ( 51 – 53 ) cortisol concentrations. Furthermore, given that cortisol plays an important role in lipid metabolism ( 54 , 55 ), obesity might be a significant confounding variable in the inconsistent pattern of results ( 56 ).…”

Section: Introductionmentioning

confidence: 99%

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Associations Between Morning Salivary and Blood Cortisol Concentrations in Individuals With Obstructive Sleep Apnea Syndrome: A Meta-Analysis

et al. 2021

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BackgroundObstructive sleep apnea syndrome (OSAS) may be associated with an increase in hypothalamic-pituitary-adrenocortical axis activity (HPA AA). We reviewed research comparing morning salivary and blood (serum and plasma) cortisol concentrations of individuals with OSAS to those of healthy controls.MethodsWe made a systematic search without any restrictions of the PubMed/Medline, Scopus, Cochrane Library, and Web of Science databases for relevant articles published up to August 25, 2019.ResultsSixteen studies were analyzed in this meta-analysis; five studies compared morning salivary concentrations, five compared serum concentrations, four compared plasma cortisol concentrations, and two compared both salivary and plasma concentrations. In pediatric samples, compared to healthy controls, those with OSAS had significantly lower saliva morning cortisol concentrations (MD = -0.13 µg/dl; 95% CI: 0.21, -0.04; P = 0.003). In contrast, no significant differences were observed for serum cortisol concentrations, plasma cortisol concentrations, or salivary morning cortisol concentrations between adults with and without OSAS (p = 0.61, p = 0.17, p = 0.17).ConclusionCortisol concentrations did not differ between adults with OSAS and healthy controls. In contrast, morning salivary cortisol concentrations were lower in children with OSAS, compared to healthy controls. Given that a reduced HPA AA is observed among individuals with chronic stress, it is conceivable that children with OSAS are experiencing chronic psychophysiological stress.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Associations Between Morning Salivary and Blood Cortisol Concentrations in Individuals With Obstructive Sleep Apnea Syndrome: A Meta-Analysis

et al. 2021

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“…At the same time, other models consider other personality traits as burnout factors -e.g., self-efficacy [5], extraversion, conscientiousness, openness [6], coping strategies, mindfulness [7], and conditions associated with the workplace (the average number of hours of sleep per night and number of working hours per week [8]). There is a consensus that burnout may also be based on various stress-related neuroendocrine mechanisms [9,10].…”

Section: Introductionmentioning

confidence: 99%

Healthy And Unhealthy Lifestyles As Factors Of Occupational Burnout In Obstetrics And Gynecology Physicians

2023

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This article investigates healthy and unhealthy lifestyles and its components (physical activity, drinking alcohol, consumption of caffeinated products, tobacco use) as factors of occupational burnout in obstetrics and gynecology physicians. Material and Methods. A total of 132 physicians and nurses from the different clinics of Irkutsk were surveyed. We used Maslach Burnout Inventory (MBI), SF-12, and Godin Leisure-Time Exercise Questionnaire. Results: Differences in healthy and unhealthy lifestyles between physicians and nurses employed in obstetrics and gynecology, with or without a high burnout, were revealed. According to the obtained results, the frequency of alcohol consumption was directly related to burnout. In study subjects engaged in low and moderate physical activity, burnout occurred briefly or rarely. The differences became more pronounced when we excluded physicians and nurses with poor physical health from consideration, because they did not exercise much. According to the results of logistic regression, the probability of burnout and reduced level of quality of life among physicians and nurses increased with a bigger family size, lower work experience, and less time spent on moderate physical activity. Conclusion: Healthy and unhealthy lifestyles can cause healthcare employee burnout. Physicians and nurses with a high burnout consumed stronger alcohol and spent less time in moderate physical activity.

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Changes in Relative Telomere Length in Patients with Obstructive Sleep Apnea Syndrome on the Background of CPAP Therapy: A Pilot Study

Мадаева

Курашова

Ухинов

et al. 2023

Neurosci Behav Physi

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Pathophysiological aspects of neuro-endocrine regulation system in patients with obstructive sleep apnea syndrome

Abstract: The changes in the hypothalamic-pituitary-gonadal system are a manifestation of disturbances of the mechanisms of self-regulation and compensation that indicates the presence of maladaptive reactions of the neuroendocrine system.

Cited by 7 publications

References 14 publications

Associations Between Morning Salivary and Blood Cortisol Concentrations in Individuals With Obstructive Sleep Apnea Syndrome: A Meta-Analysis

Associations Between Morning Salivary and Blood Cortisol Concentrations in Individuals With Obstructive Sleep Apnea Syndrome: A Meta-Analysis

Healthy And Unhealthy Lifestyles As Factors Of Occupational Burnout In Obstetrics And Gynecology Physicians

Changes in Relative Telomere Length in Patients with Obstructive Sleep Apnea Syndrome on the Background of CPAP Therapy: A Pilot Study

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