Pathophysiological cytokine network in primary Sjögren's syndrome

Pers, Jacques‐Olivier; Tobón, Gabriel J.; Youinou, Pierre

doi:10.1016/j.lpm.2012.04.029

Cited by 15 publications

(7 citation statements)

References 77 publications

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“…Notably, our observations that pancreatic protein-immunised mice did not exhibit any detectable immune responses and pathological changes in SG further confirm the antigen specificity against SG in ESS model. Earlier studies have suggested Th1 cytokine-mediated inflammatory responses in SS patients,33–36 but increasing evidence indicates the involvement of IL-17 in autoimmune inflammation during the pathogenesis of SS 37. Here, we reveal a significantly enhanced Th17 response occurring 7 days prior to the predominant Th1 response during ESS induction.…”

Section: Discussionsupporting

confidence: 46%

Th17 cells play a critical role in the development of experimental Sjögren's syndrome

et al. 2014

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Section: Discussionsupporting

confidence: 46%

Th17 cells play a critical role in the development of experimental Sjögren's syndrome

et al. 2014

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“…Th17 cells secrete IL‐17, which constitutes a family of cytokines that includes six members, from A to F, with a wide range of biological activities . Recent studies have demonstrated the involvement of IL‐17 in autoimmune inflammation during the pathogenesis of pSS and have revealed elevated levels of IL‐17A in body fluids from patients with pSS, including tears, saliva and serum . An analysis of mouse models showed that IL‐17‐deficient mice were completely resistant to ESS induction, and adoptive transfer of Th17 cells drove the development of ESS in IL‐17 KO mice .…”

Section: Discussionmentioning

confidence: 99%

CP‐25 Alleviates Experimental Sjögren's Syndrome Features in NOD/Ltj Mice and Modulates T Lymphocyte Subsets

Zhang

et al. 2018

Basic Clin Pharma Tox

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Primary Sjögren's syndrome (pSS) is a chronic inflammatory autoimmune illness of the moisture-producing glands such as salivary glands that is characterized by various immune abnormalities. The aetiology of pSS remains unclear and there is no curative agent. In this study, we investigated the putative therapeutic effects on a NOD/Ltj mouse model of Sjögren's syndrome-like disorders of an ester derivative of paeoniflorin, paeoniflorin-6'O-benzene (termed CP-25). Our study showed that CP-25 alleviated effectively clinical manifestations in NOD/Ltj mice resulting, for example, in increased salivary flow and reduced histopathological scores. Furthermore, CP-25 decreased lymphocyte viability in NOD/Ltj mice and attenuated the infiltration of Th1 cells and Th2 cells into the salivary glands of NOD/Ltj mice. In the spleen on NOD/Ltj mice, CP-25 skewed the ratio of Th17 and regulatory T cells towards regulatory T cells. After treatment, concentrations of anti-La/SSB and IgG antibodies were reduced and the titre of the inflammatory cytokines IFN-γ, IL-4, IL-6 and IL-17A in the serum on NOD/Ltj mice was alleviated. Thus, we define CP-25 as a novel compound that is a potent therapeutic agent for pSS by modulating T lymphocyte subsets. Future studies will validate the use of CP-25 as a therapeutic strategy for the treatment of pSS.

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“…SS is classified as either primary, when occurring alone, or secondary, when occurring along with another autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus or myositis. Although the origin of the disease remains unknown, epithelial cell activation is considered to play a central role in the multifactorial pathogenesis of SS [ 67 , 68 , 69 , 70 ]. Several autoantibodies have been detected in patients suffering from SS and associated with clinical features of SS; including against ribonucleoproteins (Ro/SS-A) and La/SS-B), CA19-9, muscarinic M3 receptors and pancreatic ductal cells [ 71 , 72 , 73 , 74 ].…”

Section: Aquaporins and Pathophysiological Conditionsmentioning

confidence: 99%

Aquaporins in Salivary Glands: From Basic Research to Clinical Applications

Delporte

Bryla

Perret

2016

IJMS

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Salivary glands are involved in saliva secretion that ensures proper oral health. Aquaporins are expressed in salivary glands and play a major role in saliva secretion. This review will provide an overview of the salivary gland morphology and physiology of saliva secretion, and focus on the expression, subcellular localization and role of aquaporins under physiological and pathophysiological conditions, as well as clinical applications involving aquaporins. This review is highlighting expression and localization of aquaporins in human, rat and mouse, the most studied species and is pointing out possible difference between major salivary glands, i.e., parotid, submandibular and sublingual glands.

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Pathophysiological cytokine network in primary Sjögren's syndrome

Cited by 15 publications

References 77 publications

Th17 cells play a critical role in the development of experimental Sjögren's syndrome

Th17 cells play a critical role in the development of experimental Sjögren's syndrome

CP‐25 Alleviates Experimental Sjögren's Syndrome Features in NOD/Ltj Mice and Modulates T Lymphocyte Subsets

Aquaporins in Salivary Glands: From Basic Research to Clinical Applications

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