Pathophysiological effects of cadmium(II) on human health-a critical review

Bhattacharyya, Kaustav; Sen, Debrup; Laskar, Payel; Saha, Tania; Kundu, Gautam; Chaudhuri, Alok Ghosh; Ganguly, Subhadeep

doi:10.1515/jbcpp-2021-0173

Cited by 14 publications

(9 citation statements)

References 121 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is known that cadmium levels are five times higher than those of non-smokers [17][18][19][20]. By inhalation, the cadmium cysteine complex enters the circulatory system [21]. Cadmium binds to albumin and metallothionein when it enters the bloodstream and reaches the liver.…”

Section: Cadmium (Cd)mentioning

confidence: 99%

Accumulation of Toxic Elements Disrupts Metabolic Processes in the Human: Review

Ali¹

2023

JBB

View full text Add to dashboard Cite

Background Toxic elements are inorganic substances that do not have a physiological or functional role within the human body. Most metabolic processes are disrupted due to their accumulation through prolonged exposure to them from the environment. Toxic elements make up an extensive and very toxicologically dangerous group of substances. Usually, four elements are considered: Hg (mercury), Pb (lead), Cd (cadmium), and As (arsenic). ResultsExposure to methylmercury has been associated with widespread neurological injury and diffuse encephalopathy. However, selectivity has been noted. The substance is toxic to some groups of nerve cells over others. Clinical signs of acute mercury exposure include Headache, nausea, and tremors. After chronic exposure, the onset of peripheral neuropathies has been described. ConclusionThe accumulation of toxic heavy elements in general and cadmium, mercury, and lead (Pd) in particular leads to an imbalance in the metabolic processes and results in fat accumulation in the body. Thus, it causes obesity.

show abstract

Section: Cadmium (Cd)mentioning

confidence: 99%

Accumulation of Toxic Elements Disrupts Metabolic Processes in the Human: Review

Ali¹

2023

JBB

View full text Add to dashboard Cite

show abstract

“…Heavy metal pollution poses many risks to human health considering that human consumption of cadmium-contaminated food, water or air has been associated with the development of severe kidney, lung, liver, bone and reproductive system diseases. Moreover, according to the International Agency for Research on Cancer, Cd is now designated as a human carcinogen [103,104]. However, some microbes survive well in Cd-polluted environments as they have evolved various metal resistance mechanisms [105].…”

Section: Resistance To Cadmiummentioning

confidence: 99%

Extraintestinal Pathogenic Escherichia coli: Beta-Lactam Antibiotic and Heavy Metal Resistance

et al. 2022

View full text Add to dashboard Cite

Multiple-antibiotic-resistant (MAR) extra-intestinal pathogenic Escherichia coli (ExPEC) represents one of the most frequent causes of human nosocomial and community-acquired infections, whose eradication is of major concern for clinicians. ExPECs may inhabit indefinitely as commensal the gut of humans and other animals; from the intestine, they may move to colonize other tissues, where they are responsible for a number of diseases, including recurrent and uncomplicated UTIs, sepsis and neonatal meningitis. In the pre-antibiotic era, heavy metals were largely used as chemotherapeutics and/or as antimicrobials in human and animal healthcare. As with antibiotics, the global incidence of heavy metal tolerance in commensal, as well as in ExPEC, has increased following the ban in several countries of antibiotics as promoters of animal growth. Furthermore, it is believed that extensive bacterial exposure to heavy metals present in soil and water might have favored the increase in heavy-metal-tolerant microorganisms. The isolation of ExPEC strains with combined resistance to both antibiotics and heavy metals has become quite common and, remarkably, it has been recently shown that heavy metal resistance genes may co-select antibiotic-resistance genes. Despite their clinical relevance, the mechanisms underlining the development and spread of heavy metal tolerance have not been fully elucidated. The aim of this review is to present data regarding the development and spread of resistance to first-line antibiotics, such as beta-lactams, as well as tolerance to heavy metals in ExPEC strains.

show abstract

“…The organs that bear maximum cadmium load are liver and kidney. Elevated cadmium levels is associated with chronic kidney disease 4,5 .…”

Section: Introductionmentioning

confidence: 99%

Evidence for the Augmented Cd(II) Biosorption by Cd(II) resistant strain Candida tropicalis XTA1874 From Contaminated Aqueous Medium

Bhattacharyya

Bhattacharjee

Ganguly

2023

Preprint

Self Cite

View full text Add to dashboard Cite

Cadmium is one of the most dreadful heavy metals and is becoming a major toxicant in ground water with increasing concentration above the WHO Guidelines in drinking water (0.003ppm). The conventional physico-chemical remediation techniques are not favorable in removing the contaminants such as Cd(II) fruitfully. Bio-based techniques used in Cd(II) removal from contaminated water provide cheap, eco-friendly and efficient means of environmental remediation. The present study is aimed at determining the optimized nutritional conditions for the optimal growth and Cd(II) remediation capacity for a developed Cd(II) resistant yeast strain named Candida tropicalis XTA 1874 isolated from contaminated water-body in West Bengal. By analyzing the optimization conditions, a synthetic medium was developed and the composition has been given in the main text. The biosorption process followed pseudo second order kinetics proving chemisorption as the rate limiting step in the adsorption process. The equilibrium biosorption of Cd(II) by the strain was fitted to the Langmuir model and hence the biosorption was a monolayer process both before and after optimization. The strain showed much better Cd(II) adsorption capacity under the optimized nutritional conditions (qmax=847.476±0.008 mg/g). The above findings amply demonstrated the strain to be an effective biosorbent in removing Cd(II) from contaminated water.

show abstract

Pathophysiological effects of cadmium(II) on human health-a critical review

Cited by 14 publications

References 121 publications

Accumulation of Toxic Elements Disrupts Metabolic Processes in the Human: Review

Accumulation of Toxic Elements Disrupts Metabolic Processes in the Human: Review

Extraintestinal Pathogenic Escherichia coli: Beta-Lactam Antibiotic and Heavy Metal Resistance

Evidence for the Augmented Cd(II) Biosorption by Cd(II) resistant strain Candida tropicalis XTA1874 From Contaminated Aqueous Medium

Contact Info

Product

Resources

About