Pathophysiological Mechanisms in Immune Inner Ear Disease

Dornhoffer, John L.; Arenberg, Julie G.; Arenberg, I. Kaufman; Shambaugh, G. E.

doi:10.3109/00016489709124018

Cited by 18 publications

(10 citation statements)

References 32 publications

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“…Several hypotheses had been postulated to explain the basis of association of CD with sensorineural hearing loss such as impaired nutrient and vitamin absorption (such as Vit B12, folate, vitamin D, E, pyridoxine and biopterin) [20,21], cerebral vasculitis [22], the existence of antineuronal antibodies, invasion of activated lymphocytes into the labyrinth, immune complex deposition that leads to tissue injury [23,24], and immunopathology leading to inner ear immune response. There is a continuous recirculation of immuno-competent cells in this area of the inner ear.…”

Section: Discussionmentioning

confidence: 99%

“…Type II and III immunological reactions would be causing inner ear pathology together in pediatric CD patients [28,29]. In type II reaction, an immunoglobulin directed against a tissue or organ is basic mechanism for injury of endolymphatic sac as in the pathogenesis of Meniere's disease and in type III reaction an immune complex deposition leads to inner ear pathology as in the pathogenesis of Wegeners granulomatosis [24]. Pratesi et al demonstrated in vitro that antiendomysial antibodies immunofluoresce with cerebral vasculature [30].…”

Section: Discussionmentioning

confidence: 99%

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Sensorineural hearing loss in pediatric celiac patients

Hızlı

Karabulut

Özdemir

et al. 2011

International Journal of Pediatric Otorhinolaryngology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sensorineural hearing loss in pediatric celiac patients

Hızlı

Karabulut

Özdemir

et al. 2011

International Journal of Pediatric Otorhinolaryngology

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“…In our study we did not find a difference between contralateral suppression amplitudes of CD and control groups, but the mean speech discrimination score in CD patients was lower than that in the control group. Autoimmune inner ear disease is the result of a direct immune attack against an endogeneous antigen or a cross-reacting exogeneous epitope such as food, drug or viral components [20] . The clinical presentation of inner ear disease is extremely variable and dependent on the type of immune reaction as well as the site of tissue injury within the inner ear.…”

Section: Discussionmentioning

confidence: 99%

Audiological Findings in Celiac Disease

Karabulut¹,

Hızlı

Dağlı

et al. 2011

ORL

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Objective: Celiac disease (CD) is a gluten-triggered immune enteropathy caused by a genetic predisposition. Recent papers suggest that CD is increasingly recognized by extraintestinal findings. The aim of this study was to investigate the effect of CD on hearing pathway including the olivocochlear efferent system in children. Methods: Forty-one pediatric CD patients and 31 controls were included in the study. Both groups were evaluated with audiometry, tympanometry, transiently evoked otoacoustic emission (TEOAE), distortion product otoacoustic emission (DPOAE), and contralateral suppression of the TEOAE. Results: The threshold at 250 Hz of the patients with CD was significantly higher (p < 0.05 in CD compared to control group, p < 0.0001). The signal to noise ratio (SNR) amplitudes in DPOAE testing and the SNR amplitudes with and without contralateral acoustic stimulus in TEOAE testing were significantly lower at 1,000 Hz in the CD compared to the control group. There was no significant difference between the CD and the control group regarding contralateral suppression amplitudes. Conclusion: CD seems to have an important impact on the auditory system, and results in an elevation of the thresholds at 250 Hz on audiometry and a decrease in the amplitudes of DPOAE and linear TEOAE at 1,000 Hz in children.

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“…Although results from these studies suggest a correlation between sustained elevated IOP, and abnormal auditory and vestibular function, the fact that the production of aqueous fluid in the anterior chamber is controlled by different mechanisms to that of endolymphatic fluid within the inner ear overshadows this association. Given the varied pathogenesis of glaucoma, it may be possible that the common mechanism shared between glaucoma and Meniere's disease is a peripheral sensory end organ disturbance secondary to disrupted blood flow or common immunological disturbance 87–89 . However, further research is required to clarify and explain these earlier findings.…”

Section: Vestibularmentioning

confidence: 99%

Is primary open‐angle glaucoma part of a generalized sensory neurodegeneration? A review of the evidence

O’Hare¹,

Rance²,

McKendrick³

et al. 2012

Clinical Exper Ophthalmology

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Open-angle glaucoma is an optic neuropathy that has a multifarious aetiological profile. Emerging theories suggest that a group of factors induce optic nerve injury in innately susceptible aging optic nerves. These factors have the potential to impact on the function of other vulnerable neurons within the central nervous system of older patients. Although changes within the visual pathways due to retinal ganglion cell dysfunction and death are well established, research exploring the behaviour of other sensory systems in individuals with glaucoma is limited. This review summarizes what is known about these other non-visual sensory changes, explores whether glaucoma is in fact part of a global neurodegenerative condition, and suggests areas for future research direction.

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Pathophysiological Mechanisms in Immune Inner Ear Disease

Cited by 18 publications

References 32 publications

Sensorineural hearing loss in pediatric celiac patients

Sensorineural hearing loss in pediatric celiac patients

Audiological Findings in Celiac Disease

Is primary open‐angle glaucoma part of a generalized sensory neurodegeneration? A review of the evidence

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