Pathophysiological mechanisms of portal hypertension syndrome development

Romaniuk, T. V.; IIa, Dziubanovs'kyĭ; Kuziv, OV

doi:10.15407/fz60.01.098

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…[ 15 16 17 18 19 ] Liver cirrhosis and its associated hypersplenism are common among liver transplant recipients. [ 20 21 22 23 ] Macrophages in the hypertrophied spleen can destroy circulating blood cells,[ 24 ] including leukocytes, red blood cells, and platelets, resulting in pancytopenia. Liver transplantation can reduce portal vein pressure and alleviate hypersplenism.…”

Section: Introductionmentioning

confidence: 99%

Individualized Immunosuppressive Protocol of Liver Transplant Recipient Should be Made Based on Splenic Function Status

Jiang

Du²,

Xiao³

et al. 2016

Chinese Medical Journal

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Background:Lymphocyte subsets play important roles in rejection in liver transplant recipients, and the effect of splenic function on these roles remains unknown. The aim of this study was to explore the feasibility to adjust immunosuppressive agents based on splenic function status through detecting the lymphocyte subsets in liver transplant recipients.Methods:The lymphocyte subsets of 49 liver transplant recipients were assessed in the 309th Hospital of Chinese People's Liberation Army between June 2014 and August 2015. The patients were divided into splenectomy group (n = 9), normal splenic function group (n = 24), and hypersplenism group (n = 16). The percentages and counts of CD4+ T, CD8+ T, natural killer (NK) cell, B-cell, regulatory B-cell (Breg), and regulatory T-cell (Treg) were detected by flow cytometer. In addition, the immunosuppressive agents, histories of rejection and infection, and postoperative time of the patients were compared among the three groups.Results:There was no significant difference of clinical characteristics among the three groups. The percentage of CD19+CD24+CD38+ Breg was significantly higher in hypersplenism group than normal splenic function group and splenectomy group (3.29 ± 0.97% vs. 2.12 ± 1.08% and 1.90 ± 0.99%, P = 0.001). The same result was found in CD4+CD25+FoxP3+ Treg percentage (0.97 ± 0.39% vs. 0.54 ± 0.31% and 0.56 ± 0.28%, P = 0.001). The counts of CD8+ T-cell, CD4+ T-cell, and NK cell were significantly lower in hypersplenism group than normal splenic function group (254.25 ± 149.08 vs. 476.96 ± 225.52, P = 0.002; 301.69 ± 154.39 vs. 532.50 ± 194.42, P = 0.000; and 88.56 ± 63.15 vs. 188.33 ± 134.51, P = 0.048). Moreover, the counts of CD4+ T-cell and NK cell were significantly lower in hypersplenism group than splenectomy group (301.69 ± 154.39 vs. 491.89 ± 132.31, P = 0.033; and 88.56 ± 63.15 vs. 226.00 ± 168.85, P = 0.032).Conclusion:Splenic function status might affect the immunity of liver transplant recipients, that should be considered when we make immunosuppressive protocols.

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Section: Introductionmentioning

confidence: 99%

Individualized Immunosuppressive Protocol of Liver Transplant Recipient Should be Made Based on Splenic Function Status

Jiang

Du²,

Xiao³

et al. 2016

Chinese Medical Journal

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Peculiarities of Labor Relations Regulation amid Imposition of Martial Law and Special Economic Measures: Problems and Prospects for Harmonization

Paramonova

2024

Aktualʹnye problemy rossijskogo prava

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The need to counter external threats to Russia’s national security predetermined the development of new and improvement of existing regulations in 2022. An assessment and comparative analysis of the legal means and innovations available in the field of labor confirmed that there is an objective need for comprehensive legal regulation of labor relations during emergency events. Considering the features of the organization of labor activity amid imposition of martial law and the operation of special economic measures, the author exposes conceptual uncertainty, discrepancies in the order, content and limits of impact on the sphere of labor, difficulties in applying and controversial issues of innovations were revealed, the lack of a general concept and uniformity of labor regulation in the conditions of emergency circumstances. It is proposed to streamline the regulations by focusing on the fact that countering threats to national security is the system-forming basis for the differentiation of the legal regulation of relations in the sphere of labor.

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Pathophysiological mechanisms of portal hypertension syndrome development

Cited by 2 publications

References 16 publications

Individualized Immunosuppressive Protocol of Liver Transplant Recipient Should be Made Based on Splenic Function Status

Individualized Immunosuppressive Protocol of Liver Transplant Recipient Should be Made Based on Splenic Function Status

Peculiarities of Labor Relations Regulation amid Imposition of Martial Law and Special Economic Measures: Problems and Prospects for Harmonization

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