Pathophysiology and Prognosis of Sudden Deafness with Special Reference to the N&lt;sub&gt;1&lt;/sub&gt; Latency

Ikeda, Katsuhisa; Kusakari, Jun; Kobayashi, Toshimitsu; Inamura, Naoki; Shibuya, Masaki; Takeyama, Minoru; Itoh, Zenya; Takasaka, Tomonori

doi:10.1159/000275943

Cited by 6 publications

(4 citation statements)

References 16 publications

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“…It is difficult to estimate the efficiency of the various treatment modalities used in sudden hearing loss 6 , 7 . The factors considered to be important in the prognosis of this condition are: severity of hearing loss, duration of symptoms before treatment, presence of vertigo, type of audiogram, age of patient, hearing level in the opposite ear, erythrocyte sedimentation rate, coexistence of metabolic diseases such as hypertension and diabetes mellitus, and audiological parameters 2 , 8 – 12 …”

Section: Introductionmentioning

confidence: 99%

Impact of prognostic factors on recovery from sudden hearing loss

et al. 2007

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Section: Introductionmentioning

confidence: 99%

Impact of prognostic factors on recovery from sudden hearing loss

et al. 2007

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“…Electrocochleography of patients with SD has shown that the patients who had a normal latency for N 1 all recovered completely, but in cases with an increased latency or missing N 1 the prognosis was worse [61].…”

Section: Studies On Patients With Sdmentioning

confidence: 99%

Sudden Deafness – A Critical Evaluation of Pathogenesis and ‘Cure’

Hultcrantz¹

1999

Otorhinolaryngol Nova

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Objective: To discuss the possible etiology, pathogenesis and ‘cure’ of idiopathic sudden deafness (SD). Method: A review was made of different methods for the study of inner-ear physiology, especially its microcirculation, relating them to clinical evaluation and praxis for SD. Results: Cochlear blood flow (CBF) can be measured quantitatively with the microsphere method in animals. Direct qualitative measurements can be performed using the laser Doppler method. The CBF is partly autoregulated, but to a lesser degree than cerebral blood flow. Sympathetic stimulation decreases CBF up to 25%. Noise does not influence total CBF but seems to reduce blood flow in the lateral wall. Nicotinic acid, hemodilution and osmotic drugs increase the CBF proportionally. Carbogen increases the CBF but also creates acidosis. Treating patients with SD in accordance with these findings does not show any convincing effect compared to no treatment. Conclusion: More and more diseases have been identified which can have SD as a symptom. It is important to investigate to identify these treatable cases. Idiopathic cases should not be exposed to hazardous systemic medication or surgery. Local treatment through the round window will be the treatment modality for the future, but more basic research is necessary.

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“…It has been discussed which is more involved in SD, the inner ear or the retrocochlear locations (5)(6)(7)(8)(9). Portmann et al (5) reported that retrocochlear dysfunction was involved in some SD cases as determined by electrocochleography (ECochG).…”

Section: Introductionmentioning

confidence: 99%

“…Portmann et al (5) reported that retrocochlear dysfunction was involved in some SD cases as determined by electrocochleography (ECochG). Ikeda et al (6) divided SD cases into three groups based on N 1 latency in the ECochG. However, it is considered difficult to determine the primary site involved based on only the compound action potential (CAP) findings in ECochG.…”

Section: Introductionmentioning

confidence: 99%

Lesion Site in Sudden Deafness: Study with Electrocochleography and Transiently Evoked Otoacoustic Emission

Ota

Oda²

1999

Acta Oto-Laryngologica

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We examined electrocochleogram (ECochG) and transiently evoked otoacoustic emission (TEOAE) on five cases of sudden sensorineural hearing loss which had no abnormalities detected on diagnostic imagings and showed complete recovery of hearing. At the initial examination, three cases showed a broadened wave 1 with prolonged latency in the auditory brainstem response (ABR) at 90 dB HL. The ECochG AP showed a broad waveform, low amplitude, and high threshold. CM threshold, although increased, was relatively well preserved compared with hearing threshold measured with conventional pure-tone audiometry. The thresholds in TEOAE examination were similar to those for CM and preserved better when compared with pure-tone audiometric thresholds. These findings suggest that the location of the disorder in these three cases involved not only the cochlea but also the retrocochlear auditory pathway. The other two cases showed normal ABR waveforms at 90 dB HL at the initial examinations. ECochG examination showed that a normal AP in one case and a smaller amplitude AP, an elevated threshold, and normal waveform of AP in the other ear. CM thresholds coincided with the conventional audiometry thresholds. These findings suggest that hearing loss in these two cases involved primarily the sensory hair cells.

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Pathophysiology and Prognosis of Sudden Deafness with Special Reference to the N<sub>1</sub> Latency

Cited by 6 publications

References 16 publications

Impact of prognostic factors on recovery from sudden hearing loss

Impact of prognostic factors on recovery from sudden hearing loss

Sudden Deafness – A Critical Evaluation of Pathogenesis and ‘Cure’

Lesion Site in Sudden Deafness: Study with Electrocochleography and Transiently Evoked Otoacoustic Emission

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