Pathophysiology of chronic daily headache

Srikiatkhachorn, Anan

doi:10.1007/s11916-001-0071-5

Cited by 15 publications

(12 citation statements)

References 44 publications

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“…Recently, a polymorphism of the gene coding for tryptophan hydroxylase, the rate-limiting enzyme in serotonin biosynthesis, was shown to be associated with anger-related traits of personality [31]. Finally, recent studies suggested that patients with chronic daily headache have a significant impairment of serotonin metabolism [32,33]. So the dysfunction of cerebral serotonergic system seems to be one of the key features in the mechanism of transformation of an episodic to a chronic form of headache and it may play a role in the abnormalities in anger experience and control observed in our patients.…”

Section: Discussionmentioning

confidence: 99%

Anger and emotional distress in patients with migraine and tension–type headache

Perozzo¹,

Savi

Castelli

et al. 2005

J Headache Pain

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The objective was to evaluate the prevalence and the characteristics of anger and emotional distress in migraine and tension– type headache patients. Two hundred and one headache patients attending the Headache Center of the University of Turin were selected for the study and divided into 5 groups: (1) migraine, (2) episodic tension–type headache, (3) chronic tension–type headache, (4) migraine associated with episodic tension–type headache and (5) migraine associated with chronic tension–type headache. A group of 45 healthy subjects served as controls. All the subjects completed the State–Trait Anger Expression Inventory, the Beck's Depression Inventory and the Cognitive Behavioral Assessment. Anger control was significantly lower in all headache patients ( p <0.05) except in migraineurs. Patients with migraine and tension–type headache showed a significantly higher level of angry temperament and angry reaction ( p <0.05). In addition, chronic tension–type headache and migraine associated with tension–type headache patients reported a higher level of anxiety ( p <0.05), depression ( p <0.001), phobias ( p <0.001) and obsessive–compulsive symptoms ( p <0.01), emotional liability ( p <0.001) and psychophysiological disorders ( p <0.001). Our study shows that chronic tension–type headache and migraine associated with tension–type headache patients present a significant impairment of anger control and suggests a connection between anger and the duration of headache experience.

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Section: Discussionmentioning

confidence: 99%

Anger and emotional distress in patients with migraine and tension–type headache

Perozzo¹,

Savi

Castelli

et al. 2005

J Headache Pain

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“…Injury to peripheral tissues or chronic nociceptive input may increase the sensitivity of nociception to produce peripheral sensitization [16,25]. During the migraine state, neuropeptides (substance P, calcitonin gene-related peptide, and neurokinin A) released from nerve fibers react with the blood vessel walls and produce a sterile inflammation [26].…”

Section: Peripheral and Central Sensitizationmentioning

confidence: 99%

“…During the migraine state, neuropeptides (substance P, calcitonin gene-related peptide, and neurokinin A) released from nerve fibers react with the blood vessel walls and produce a sterile inflammation [26]. It may be that repeated episodes of this neurogenic inflammation could chronically sensitize nociceptors, lowering the threshold for future attacks, and also lead to spontaneous activity and expansion of receptive fields of nociceptors [16,25].…”

Section: Peripheral and Central Sensitizationmentioning

confidence: 99%

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Risk factors for chronic daily headache

Scher

Lipton

Stewart

2002

Current Science Inc

104

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There are many people who experience headaches that are independent of illness, injury, or hangover. Approximately 4% of the population suffer from headaches on a daily or near-daily basis. It is apparent that patients with chronic daily headache in community samples differ in important ways from patients with chronic daily headache in subspecialty clinics. In this manuscript, we review clinic-based data on risk factors for chronic daily headache and summarize the current data on the epidemiology of chronic daily headache.

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“…Tryptophan metabolism pathway has a prominent position in the pathologic process of neurodegenerative diseases, and acts through various regulations. A good example is the serotonin level in headache patients, which was typically abnormal [ 18 , 19 ]. Kynurenic acid has the effect of protection on CNS, while kynurenine and quinolinic acid could be neurotoxic [ 20 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

Metabolomics Strategy Using High Resolution Mass Spectrometry Reveals Novel Biomarkers and Pain-Relief Effect of Traditional Chinese Medicine Prescription Wu-Zhu-Yu Decoction Acting on Headache Modelling Rats

Liu

Zhang³

et al. 2017

Molecules

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Headache is a common episodic or chronic neurologic disorder. Treatment options and diagnosis are restricted by an incomplete understanding of disease pathology and the lack of diagnostic markers. Wu-Zhu-Yu decoction (WZYD), a traditional Chinese medicine (TCM) formula containing four TCM herbs, is commonly used in the treatment of headache in China. To deeply understand more about headache and investigate the pain-relief mechanism of WZYD, a comprehensive metabolomics study combined with multivariate data processing strategy was carried out. An LC-high resolution mass spectrometry-based metabolomics approach was applied to characterize metabolic biomarker candidates. Multiple pattern recognition including principal component analysis-discriminant analysis, partial least squares-discriminant analysis and hierarchical cluster analysis were used to determine groups and confirm important variables. A total of 17 potential biomarkers were characterized and related metabolic pathways were identified. The study demonstrated that the established metabolomics strategy is a powerful approach for investigating the mechanism of headache attack and WZYD. In addition, the approach may highlight biomarkers and metabolic pathways and can capture subtle metabolite changes from headache, which may lead to an improved mechanism understanding of central nervous system diseases and TCM treatment.

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Pathophysiology of chronic daily headache

Cited by 15 publications

References 44 publications

Anger and emotional distress in patients with migraine and tension–type headache

Anger and emotional distress in patients with migraine and tension–type headache

Risk factors for chronic daily headache

Metabolomics Strategy Using High Resolution Mass Spectrometry Reveals Novel Biomarkers and Pain-Relief Effect of Traditional Chinese Medicine Prescription Wu-Zhu-Yu Decoction Acting on Headache Modelling Rats

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