2022
DOI: 10.3390/ijms23126698
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Pathophysiology of Diverticular Disease: From Diverticula Formation to Symptom Generation

Abstract: Diverticular disease is a common clinical problem, particularly in industrialized countries. In most cases, colonic diverticula remain asymptomatic throughout life and sometimes are found incidentally during colonic imaging in colorectal cancer screening programs in otherwise healthy subjects. Nonetheless, roughly 25% of patients bearing colonic diverticula develop clinical manifestations. Abdominal symptoms associated with diverticula in the absence of inflammation or complications are termed symptomatic unco… Show more

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Cited by 28 publications
(33 citation statements)
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“…In fact, the pathogenesis of the two diseases is actually completely different. In diverticular disease, diverticula are formed due to the weakening of the muscular layer of the colon [25]. In colorectal carcinogenesis, malignant transformation is observed in polyps as a result of the adenomatous polyp/adenocarcinoma sequence triggered by genetic and epigenetic changes in cells of the mucosal area [26].…”
Section: Resultsmentioning
confidence: 99%
“…In fact, the pathogenesis of the two diseases is actually completely different. In diverticular disease, diverticula are formed due to the weakening of the muscular layer of the colon [25]. In colorectal carcinogenesis, malignant transformation is observed in polyps as a result of the adenomatous polyp/adenocarcinoma sequence triggered by genetic and epigenetic changes in cells of the mucosal area [26].…”
Section: Resultsmentioning
confidence: 99%
“…Some studies have shown that changes to the colonic wall may affect the pathogenesis of colonic DD [ 37 ]. Changes to colonic tenseness, as manifested by lower levels of collagen and elastin in the colonic wall associated with the ageing process, support this view [ 17 , 38 ]. Because our study population was slightly older than those in previous studies, this could explain the overrepresentation of pancolonic DD in our cohort.…”
Section: Discussionmentioning
confidence: 96%
“…Several factors have been associated with an increased risk of DD and its complications, including advanced age, gender, obesity, and dietary fber intake [6,[14][15][16][17]. Significant changes to dietary habits and improvements in life expectancy have also been proposed as explanations for the rising incidence of DD in Africa and Asia [6,18].…”
Section: Introductionmentioning
confidence: 99%
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“…The cecum sits on the lower right side of the abdomen, and the symptoms of cecal diverticulitis are often mistaken for appendicitis or irritable bowel syndrome. This is because diverticular disease typically occurs within the sigmoid colon, the portion of the large intestine closest to the rectum [1]. Diverticular disease of the sigmoid colon usually presents with pain in the left lower abdomen.…”
Section: Introductionmentioning
confidence: 99%