Pathophysiology of Intraocular Pressure Increase and Glaucoma Prevalence in Thyroid Eye Disease: A Mini-Review

Haefliger, Ivan O.; Arx, George von; Pimentel, Alice

doi:10.1055/s-0029-1245199

Cited by 24 publications

(16 citation statements)

References 5 publications

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“…The data on previous treatments for GO prior to referral are encouraging, suggesting that non-specialised centres tend to leave decisions for eye surgery to tertiary centres though this did not hold true for medical therapies. The explanation for a lower prevalence of glaucoma in the 2012 than the 2000 cohort is unclear, but may be due to better appreciation that raised intraocular pressure in patients with GO does not equate to glaucoma 12. The prevalence of glaucoma in the 2012 cohort (5.6%) is similar to other published data on prevalence of glaucoma in GO 13.…”

Section: Discussionsupporting

confidence: 70%

PREGO (presentation of Graves’ orbitopathy) study: changes in referral patterns to European Group On Graves’ Orbitopathy (EUGOGO) centres over the period from 2000 to 2012

et al. 2015

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Section: Discussionsupporting

confidence: 70%

PREGO (presentation of Graves’ orbitopathy) study: changes in referral patterns to European Group On Graves’ Orbitopathy (EUGOGO) centres over the period from 2000 to 2012

et al. 2015

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“…The ocular complaint was observed in 44.27% of patients; foreign body sensation being the most common presenting symptoms in 61.79%. In a study done by Kashkouli et al, bilateral proptosis (9.9%), burning sensation (5.4%), pain behind the eye (5.3%), and puffiness (4.7%) were the most common signs and symptoms [13]. The frequency of in the present study is 67% of have common symptoms.…”

Section: Original Research Articlesupporting

confidence: 55%

“…In a study by Haefliger et al, performed on 500 patient charts, the prevalence of increased IOP was noted to be 24% [13]. In 2007, Behrouzi et al reported a prevalence of 11%, and He reported an incidence of 31.3% in Chinese patients [14].…”

Section: Discussionmentioning

confidence: 98%

Hyperthyroidism and its association with intraocular pressure and dry eye in teaching medical college

Christopher

Latha

2020

Trop j ophthalmol otolaryngol

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Background: Hyperthyroidism associated eye disease is a cosmetically and functionally debilitating disease that is seen worldwide. Objectives: To investigate the association of Hyperthyroidism with Intraocular pressure and Dry eye. Methods: It was a hospital based cross sectional analysis conducted in teaching medical college for a period of 18 months from January 2018 to July 2019 in hyperthyroid patients, Consecutive sampling was done. Participants were divided into age groups. Hyperthyroidism was clinically and laboratory confirmed. Intraocular pressure and Dry eye were diagnosed by single ophthalmologist. SPSS version 22 was used for analysis. Chi square test was used to determine the association. Results: Total 70 established hyperthyroidism patients were studied. The study was female preponderance. Increased Intraocular in hyperthyroid patients was found to be statistically significant. The most common presenting eye sign was found to be diminished vision in almost all patients of Hyperthyroidism which was found to be statistically significant. Age progresses the signs tends to increase in hypothyroidism patients. Diminished vision was found to be the most common eye sign among all age groups which was statistically significant. (p<0.05) followed by Upper lid retraction and ptosis. Conclusions: Dry eye and increased IOP are commonly seen outcomes that should be managed diligently. This potentially sight-threatening condition is seen worldwide and has many functional and cosmetic consequences that need to be recognized. A larger prospective study will help us to know about the influence of risk factors on the severity of eye problems.

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“…Adjusted for other risk factors, they reported that OAG did not show significant association with hypothyroidism. Haefliger et al [32] said that glaucoma prevalence does not seem to be significantly increased in thyroid eye disease. Kakigi et al [33] reported a similar result with us.…”

Section: Discussionmentioning

confidence: 99%

Glaucomatous Optic Nerve Changes and Thyroid Dysfunction in an Urban South Korean Population

Won

Kim

2017

Journal of Ophthalmology

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Purpose. This study was performed to evaluate the relationship between intraocular pressure (IOP) and glaucomatous optic nerve change and thyroid factors in Korean population. Materials and Methods. The study included subjects who underwent health screening in Kangbuk Samsung Hospital. Detailed history taking and systemic and ocular examination including fundus photography were performed for all participants. All fundus photographs were divided into two groups based on disc and RNFL appearance: nonglaucoma and glaucoma group. Subjects were also divided into quartiles of each thyroid function parameter, and the relationship with IOP and glaucoma were analysed. Results. In univariate analysis, free T4, T3, and TSH in normal subjects and T3 in thyroid disease group were associated with the IOP. After adjusting for age and sex, the IOP tended to slightly decrease according to the level of the quartile of free T4 and T3 in normal subjects. In terms of glaucoma, on multivariate analysis, it did not show a significant correlation with any thyroid function tests. Conclusions. In normal subjects, the IOP tended to be decreased according to the level of free T4 and T3 but the amounts were clinically insignificant. Thyroid factors are not an independent risk factor for the development of glaucoma.

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Pathophysiology of Intraocular Pressure Increase and Glaucoma Prevalence in Thyroid Eye Disease: A Mini-Review

Abstract: In TED, glaucoma prevalence does not seem to be significantly increased and, from a pathophysiological standpoint, the long-term IOP increase is essentially due to episcleral venous pressure elevation.

Cited by 24 publications

References 5 publications

PREGO (presentation of Graves’ orbitopathy) study: changes in referral patterns to European Group On Graves’ Orbitopathy (EUGOGO) centres over the period from 2000 to 2012

PREGO (presentation of Graves’ orbitopathy) study: changes in referral patterns to European Group On Graves’ Orbitopathy (EUGOGO) centres over the period from 2000 to 2012

Hyperthyroidism and its association with intraocular pressure and dry eye in teaching medical college

Glaucomatous Optic Nerve Changes and Thyroid Dysfunction in an Urban South Korean Population

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