2015
DOI: 10.1038/tp.2015.137
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Pathophysiology of major depressive disorder: mechanisms involved in etiology are not associated with clinical progression

Abstract: Meta-analyses support the involvement of different pathophysiological mechanisms (inflammation, hypothalamic–pituitary (HPA)-axis, neurotrophic growth and vitamin D) in major depressive disorder (MDD). However, it remains unknown whether dysregulations in these mechanisms are more pronounced when MDD progresses toward multiple episodes and/or chronicity. We hypothesized that four central pathophysiological mechanisms of MDD are not only involved in etiology, but also associated with clinical disease progressio… Show more

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Cited by 83 publications
(63 citation statements)
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“…This is in line with previous studies that found associations of BDNF and vitamin D or vitamin D supplementation with depression but reported no interactions between the measures [64, 65]. In summary, our hypothesis of an interaction between vitamin D and BDNF with obesity was not confirmed.…”
Section: Discussioncontrasting
confidence: 43%
“…This is in line with previous studies that found associations of BDNF and vitamin D or vitamin D supplementation with depression but reported no interactions between the measures [64, 65]. In summary, our hypothesis of an interaction between vitamin D and BDNF with obesity was not confirmed.…”
Section: Discussioncontrasting
confidence: 43%
“…In contrast to previous reports which have found presence of atypical depression (Lamers et al, 2016) to be associated with higher CRP levels, we found the converse; CRP levels were lower in those with atypical features as compared to those without atypical features. Additionally, we found that there was no significant association between CRP levels and depression severity (Verduijn et al, 2015). The lack of moderator effect of serum amyloid P component and alpha-2-macroglobulin is novel and suggests specific role of systemic inflammation in predicting antidepressant treatment response.…”
Section: Discussionmentioning
confidence: 93%
“…28,29 A linear increase of inflammatory markers including CORT (P=0.025) and decrease of VD levels (P<0.001) was also found across the entire sample of major depressive disorder. 29,30 Although literatures on ethnic variances have demonstrated divergent diurnal CORT rhythms for Caucasians and Latinos, the nature of the variances are inconsistent across studies. [30][31][32] However, it seems that people with dark skin showed higher levels of CORT as a part of physiological responses to psychosocial stressors and health behaviors such as smoking.…”
Section: Discussionmentioning
confidence: 99%