Pathophysiology of pulmonary nontuberculous mycobacterial (NTM) disease

Matsuyama, Masashi; Matsumura, Sosuke; Nonaka, Mizu; Nakajima, Masayuki; Sakai, Chio; Arai, Naoki; Ueda, Kodai; Hizawa, Nobuyuki

doi:10.1016/j.resinv.2022.12.002

Cited by 7 publications

(1 citation statement)

References 107 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Disruption of the IFN-γ/IL-12 axis in HIV patients is the main trigger for disseminated NTM infections. Toll-like receptors (TLRs) on macrophages sense mycobacteria and release cytokines (IL-12 and TNF-α); this stimulates IFN-γ production and Th1 cell differentiation in HIV patients and makes them vulnerable to NTM infections [ 5 ]. Compared to HIV, the incidence of NTM disease in the population is 3.1 to 4.7 per 100,000 person-years [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Epidemiology, clinical presentation, and predictors of outcome in nontuberculous mycobacterial central nervous system infection: a systematic review

Meena,

Kumar,

Meena

et al. 2023

Trop Med Health

View full text Add to dashboard Cite

Background CNS manifestations represent an emerging facet of NTM infection with significant mortality. Due to protean presentation and low index of suspicion, many cases are often treated erroneously as tubercular meningitis or fungal infections. Objectives Literature on NTM CNS disease is scarce, with most available data on pulmonary disease. This systematic review aimed to evaluate the epidemiology, clinical presentation, diagnostic modalities, and predictors of outcome in CNS NTM infection. Methods The literature search was performed in major electronic databases (PubMed, Google Scholar, and Scopus) using keywords “CNS,” “Central nervous system,” “brain abscess,” “meningitis,” “spinal,” “Nontuberculous mycobacteria,” “NTM”. All cases of CNS NTM infection reported between January 1980 and December 2022 were included. Results A total of 77 studies (112 cases) were included in the final analysis. The mean age of all patients was 38 years, with most patients male (62.5%). Mycobacterium avium complex (MAC) was the most common aetiology, followed by M. fortuitum and M. abscessus (34.8%, 21.4% and 15.2%, respectively). The disseminated disease was found in 33% of cases. HIV (33.9%) and neurosurgical hardware (22.3%) were the common risk factors. Intracranial abscess (36.6%) and leptomeningeal enhancement (28%) were the most prevalent findings in neuroimaging. The overall case fatality rate was 37.5%. On multivariate analysis, male gender (adjusted OR 2.4, 95% CI 1.2–7.9) and HIV (adjusted OR 3.7, 95% CI 1.8–6.1) were the independent predictors of mortality). M. fortuitum infection was significantly associated with increased survival (adjusted OR 0.18, 95% CI (0.08–0.45), p value 0.012). Conclusions Current evidence shows the emerging role of rapid-grower NTM in CNS disease. Male gender and HIV positivity were associated with significant mortality, while M fortuitum carries favourable outcomes.

show abstract

Section: Introductionmentioning

confidence: 99%

Epidemiology, clinical presentation, and predictors of outcome in nontuberculous mycobacterial central nervous system infection: a systematic review

Meena,

Kumar,

Meena

et al. 2023

Trop Med Health

View full text Add to dashboard Cite

show abstract

A new N -acylhydrazone oxadiazole derivative with activity against mycobacteria

Souza,

Fróes da Motta Dacome,

Frederico Rozada

et al. 2024

Future Microbiology

View full text Add to dashboard Cite

Nontuberculous Mycobacterial Pulmonary Disease: Patients, Principles, and Prospects

Nguyen,

Haas,

Kasperbauer

et al. 2024

Clinical Infectious Diseases

View full text Add to dashboard Cite

Nontuberculous mycobacterial pulmonary disease (NTM-PD) is increasing in incidence globally and challenging to manage. The 2020 multisociety treatment guideline and the 2022 consensus recommendations provide comprehensive evidence-based guides to manage pulmonary diseases caused by the most common NTM. However, with >190 different NTM species that may require different multidrug regimens for treatment, the breadth and complexity of NTM-PD remain daunting for both patients and clinicians. In this narrative review, we aim to distill this broad, complex field into principles applicable to most NTM species and highlight important nuances, specifically elaborating on the presentation, diagnosis, principles of patient-centered care, principles of pathogen-directed therapy, and prospects of NTM-PD.

show abstract

Pathophysiology of pulmonary nontuberculous mycobacterial (NTM) disease

Cited by 7 publications

References 107 publications

Epidemiology, clinical presentation, and predictors of outcome in nontuberculous mycobacterial central nervous system infection: a systematic review

Epidemiology, clinical presentation, and predictors of outcome in nontuberculous mycobacterial central nervous system infection: a systematic review

A new N -acylhydrazone oxadiazole derivative with activity against mycobacteria

Nontuberculous Mycobacterial Pulmonary Disease: Patients, Principles, and Prospects

Contact Info

Product

Resources

About