Paths of causal influence from prenatal inflammation and preterm gestation to childhood asthma symptoms

Dessardo, Nada Sindičić; Mustać, Elvira; Banac, Srdjan; Dessardo, Sandro

doi:10.1080/02770903.2018.1493603

Cited by 8 publications

(13 citation statements)

References 28 publications

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“…(26,75,76). A series of studies from overlapping groups of authors have used causal path analysis to untangle this interdependency (73,77,78). In one study, MIR and FIR were directly causative of chronic lung disease of prematurity and indirectly causative through their influence on prematurity and mechanical ventilation (77).…”

Section: Respiratory Outcomesmentioning

confidence: 99%

“…In one study, MIR and FIR were directly causative of chronic lung disease of prematurity and indirectly causative through their influence on prematurity and mechanical ventilation (77). A more recent study redemonstrated a direct effect of FIR on chronic lung disease of prematurity, which then had a risk of progression to asthma in childhood (73). These studies are valuable but include relatively few patients and are sensitive to permutations in model design.…”

Section: Respiratory Outcomesmentioning

confidence: 99%

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Maternal-Fetal Inflammation in the Placenta and the Developmental Origins of Health and Disease

et al. 2020

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Section: Respiratory Outcomesmentioning

confidence: 99%

Section: Respiratory Outcomesmentioning

confidence: 99%

Maternal-Fetal Inflammation in the Placenta and the Developmental Origins of Health and Disease

et al. 2020

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“…There is some evidence that, in very preterm infants, a disease pathway may start with chorioamnionitis and a foetal inflammatory response, leading via a diagnosis of BPD to obstructive airway disease in childhood. [9][10][11] The definition of BPD has been modified several times in order to accurately predict respiratory morbidity after discharge from neonatal care and through the first two years of life. 12 Yet the predictability of long-term respiratory morbidity has not been systematically studied.…”

Section: Introductionmentioning

confidence: 99%

Perinatal inflammation relates to early respiratory morbidity and lung function at 12 years of age in children born very preterm

et al. 2021

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Aim: Very preterm birth may be associated with lung function impairment later in life. It is not known if this is caused by prematurity per se or by associated perinatal events, such as maternal-foetal inflammation and severity of early neonatal lung disease. We assessed these factors in a prospective cohort of very preterm infants followed from birth to middle school age. Methods:In 71 infants with a gestational age of median 27.4 (range 23.9-31.7) weeks, pro-inflammatory and modulatory cytokines were measured in umbilical cord blood and in arterial blood sampled at 6, 24 and 72 h after birth, and cumulated cytokine concentrations were calculated as area under the curve (AUC). At median 12.6 (range 12.3-13.5) years of age, pulmonary function testing was done in 53 children. Results:There was a positive correlation between days on mechanical ventilation and AUC for IL-6 (p = 0.001), IL-8 (p = 0.015) and IL-10 (p = 0.006). Infants with bronchopulmonary dysplasia (BPD; n = 32) had higher AUC for the cytokines IL-6, IL-8 and IL-10 than those without BPD (all p < 0.01). Higher levels of AUC for IL-6 at birth correlated with lower forced expiratory volume in 1 s (p = 0.030) and lower mean expiratory flow rate between 25 and 75% of forced vital capacity (p = 0.034). Conclusion:Perinatal inflammation, assessed by circulating cytokines in the first three days of life, was associated with BPD and with airway obstruction at 12 years of age.

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“…[50][51][52][53][54]56,58,60,61,63,[65][66][67] Ten studies presented their findings as odds ratios (ORs) [50][51][52][53][54][55][56][57][58]67 (Figure 3). The most common association was between HCA and asthma-related symptoms in preterm-born children with a pooled OR of 3.25 (95% CI: 2.22-4.75) [50][51][52][53][54] (Figure 4). Chronic chorioamnionitis was also found to be associated with asthma, 63 but HCA did not correlate with wheezing in term-born children.…”

Section: Results Of Synthesismentioning

confidence: 99%

Childhood atopic disorders in relation to placental changes—A systematic review and meta‐analysis

Bakoyan,

Cao,

Hansson

et al. 2024

Pediatric Allergy Immunology

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Fetal programming may arise from prenatal exposure and increase the risk of diseases later in life, potentially mediated by the placenta. The objective of this systematic review was to summarize and critically evaluate publications describing associations between human placental changes and risk of atopic disorders during childhood. The review adhered to the Preferred Reporting Items for Systematic Reviews and Meta‐analysis guidelines. The inclusion criteria were original research articles or case reports written in English describing a human placental change in relation to disease occurring in offspring during childhood. The MEDLINE and EMBASE databases were searched for eligible studies. Risk of bias (RoB) was assessed using the ROBINS‐I tool. The results were pooled both in a narrative way and by a meta‐analysis. Nineteen studies were included (n = 12,997 participants). All studies had an overall serious RoB, and publication bias could not be completely ruled out. However, five studies showed that histological chorioamnionitis in preterm‐born children was associated with asthma‐related problems (pooled odds ratio = 3.25 (95% confidence interval = 2.22–4.75)). In term‐born children, a large placenta (≥750 g) increased the risk of being prescribed anti‐asthma medications during the first year of life. Placental histone acetylation, DNA methylation, and gene expression differences were found to be associated with different atopic disorders in term‐born children. There is some evidence supporting the idea that the placenta can mediate an increased risk of atopic disorders in children. However, further studies are needed to validate the findings, properly control for confounders, and examine potential mechanisms.

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Paths of causal influence from prenatal inflammation and preterm gestation to childhood asthma symptoms

Cited by 8 publications

References 28 publications

Maternal-Fetal Inflammation in the Placenta and the Developmental Origins of Health and Disease

Maternal-Fetal Inflammation in the Placenta and the Developmental Origins of Health and Disease

Perinatal inflammation relates to early respiratory morbidity and lung function at 12 years of age in children born very preterm

Childhood atopic disorders in relation to placental changes—A systematic review and meta‐analysis

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