2012
DOI: 10.1371/journal.pone.0049927
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Pathway to Cryogen Free Production of Hyperpolarized Krypton-83 and Xenon-129

Abstract: Hyperpolarized (hp) 129Xe and hp 83Kr for magnetic resonance imaging (MRI) are typically obtained through spin-exchange optical pumping (SEOP) in gas mixtures with dilute concentrations of the respective noble gas. The usage of dilute noble gases mixtures requires cryogenic gas separation after SEOP, a step that makes clinical and preclinical applications of hp 129Xe MRI cumbersome. For hp 83Kr MRI, cryogenic concentration is not practical due to depolarization that is caused by quadrupolar relaxation in the c… Show more

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Cited by 41 publications
(83 citation statements)
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“…Using H 2 buffer gas, hp 129 Xe with up to P = 63% was generated within 6 min of SEOP at 70 kPa total gas pressure. Using 5% krypton in 95% buffer gas, the highest 83 Kr polarization of P = 29%, obtained with H 2 after 11 min of SEOP at 440 K, is comparable to that obtained previously with N 2 under similar conditions (39). Kr spin polarization in mixtures containing 5% noble gas and 95% buffer gas as a function of total SEOP gas pressure.…”
supporting
confidence: 84%
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“…Using H 2 buffer gas, hp 129 Xe with up to P = 63% was generated within 6 min of SEOP at 70 kPa total gas pressure. Using 5% krypton in 95% buffer gas, the highest 83 Kr polarization of P = 29%, obtained with H 2 after 11 min of SEOP at 440 K, is comparable to that obtained previously with N 2 under similar conditions (39). Kr spin polarization in mixtures containing 5% noble gas and 95% buffer gas as a function of total SEOP gas pressure.…”
supporting
confidence: 84%
“…39. A mixture of 5% Xe (or 5% Kr) in H 2 was used for all experiment in this work with natural abundance noble gas isotope distribution (i.e., 26.4% All catalytic combustion experiments took place in a 1.5-mm glass wall vessel that contained 25 mg Pt/Al 2 O 3 catalyst powder (i.e., 5 wt % dry loading Pt on alumina).…”
Section: Methodsmentioning
confidence: 99%
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“…The SEOP pressure was about 200 kPa, and the gas mixture was shuttled into the detection cell via pressure equilibration resulting in a pressure of 159 kPa in the detection cell. The nuclear spin polarization of hp 129 Xe was approximately 30%, hence the apparent polarization, 22 that takes xenon dilution within the mixture into account, was P app 5 7.5%.…”
mentioning
confidence: 99%