BackgroundChina is currently in a period of transition, traditional Chinese culture and modern culture gives rise to different interpretations with regard to health. In order to analyze the relationship between cultural values and residents’ health, we examined the current situation of cultural values in China and identified the mediators of Chinese culture value and health.MethodsUsing Chinese data from the 2007 and 2012 World Values Surveys (WVS), we measured the self-rate healthy and culture value, analyzed the relationship between cultural values and health by binary logistic regression, and the regression coefficient is tested to determine whether there is a mediating effect of active lifestyle and general trust. To measure culture value, we use Schwartz's scale In addition, in order to facilitate the comparison of coefficients between Logit models, the "Y * normalization" method is adopted in this paper.ResultsIt was found that, first, the traditional components of Chinese residents’ cultural values remained more prominent than modern ones, although the transformational trend from traditional to modern was obvious. Second, different cultural values had different effects on residents’ health. Specifically, “openness to change” and “collectivism” positively contributed to health, “conservation” was harmful, and “individualism” had no statistically significant effect. To better understand the relationship between cultural values and residents’ health, the specific connotations of each value were examined. Further, the mechanism of cultural values’ effect on health was analyzed. “Lifestyle” was found to play a physiological role in influencing health while “general trust” played a psychological role. ConclusionThe present study identify lifestyle and general trust are the mediators of Chinese culture value and health. Finding indicate that modern culture and transitional culture both have positive influence to health. To improve Chinese residents’ health in the context of cultural transformation, healthier lifestyles should be promoted, greater openness to modern culture should be adopted, essential traditional culture should be maintained, and social trust should be promoted. Further study should consider the two-way causal relationship of cultural values and self-reported health and find more influence trace of the two mentioned former.