Pathways of Iron Absorption

Conrad, Marcel E.; Umbreit, Jay N.

doi:10.1006/bcmd.2002.0564

Cited by 177 publications

(116 citation statements)

References 50 publications

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“…53,54 Cellular Fe uptake depends on the numbers of membrane-bound TfR. 25,55 Because of the pivotal role of TfR in Fe uptake, the TfR is more abundantly expressed in rapidly dividing cells than quiescent cells, 56,57 and high levels of TfR expression have been identified on many tumors. [58][59][60] In fact, studies have shown that expression of TfR is more abundant in breast cancer tissue than in normal tissue.…”

Section: Discussionmentioning

confidence: 99%

Roles of hormone replacement therapy and iron in proliferation of breast epithelial cells with different estrogen and progesterone receptor status

et al. 2008

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Estrogen and iron play critical roles in a female body development and were investigated in the present study in relation to in vitro cell proliferation. Prempro™, a hormone replacement therapy drug, and 17β-estradiol (E2) were shown to increase cell proliferations in estrogen receptor positive (ER + ) cells independent of progesterone receptor (PR) status. For example, increased cell proliferation was observed in ER + /PR + human breast cancer MCF-7, its matching non-cancerous human breast epithelial MCF-12A, and ER + /PR + murine mammary cancer MXT + cells, but not in ER − /PR − MDA-MB-231, its matching non-cancerous MCF-10A, and MXT − (ER − /PR + ) cells. By mimicking post-menopausal conditions of high estrogen in local breast tissue and increased iron levels due to cessation of menstrual periods, E2 and iron were shown to exert synergistic effects on proliferation of MCF-7 cells and significantly increased Ki67 and proliferating cell nuclear antigen. Western blotting of E2-treated ER + but not ER − cells showed that E2 also increased transferrin receptor (TfR). Further studies are needed to assess the mitogenic effects of iron and estrogen in normal post-menopausal breast.

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Section: Discussionmentioning

confidence: 99%

Roles of hormone replacement therapy and iron in proliferation of breast epithelial cells with different estrogen and progesterone receptor status

et al. 2008

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“…It is not known if the reductant needs to be on the lumenal side of the plasma membrane or if only the electron crosses the membrane. The MIP pathway involves a complex series of nonclassical proteins, including a protein mobilferrin, which is highly homologous to a chaperone protein calreticulin [34]. Mutations in this protein are lethal, but this may not be due to the iron transport function, because calreticulin is involved in a variety of cellular processes.…”

Section: Physiology Of Ironmentioning

confidence: 99%

Iron deficiency: A concise review

2005

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Iron deficiency is a major worldwide health problem. There is recent evidence that the anemia is only the last manifestation of the syndrome and that symptoms occur before the anemia is manifest. Advances in outlining the physiology of iron deficiency have been made, gaps remain in the current understanding. While oral iron supplement remains the mainstay, some indications for the intravenous administration have developed. This review will highlight the epidemiology, physiology, clinical presentation, and treatment options. Am.

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“…The average adult male (70 kg) has a total body iron content of approximately 4 grams, which remains relatively constant throughout adult life [2]. This is maintained by balancing loss of iron with assimilation via nutritional intake.…”

Section: Introductionmentioning

confidence: 99%

“…This is maintained by balancing loss of iron with assimilation via nutritional intake. Persistent deviation in iron intake can result in either iron deficiency, or iron overload (hemosiderosis and hemochromatosis) [2]. The most obvious manifestation of iron deficiency is anemia, but lack of iron can also have an adverse effect on the immune system [3,4] and cognitive development [5,6].…”

Section: Introductionmentioning

confidence: 99%

Preparation of iron-enriched baker's yeast and its efficiency in recovery of rats from dietary iron deficiency

2015

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A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Pathways of Iron Absorption

Cited by 177 publications

References 50 publications

Roles of hormone replacement therapy and iron in proliferation of breast epithelial cells with different estrogen and progesterone receptor status

Roles of hormone replacement therapy and iron in proliferation of breast epithelial cells with different estrogen and progesterone receptor status

Iron deficiency: A concise review

Preparation of iron-enriched baker's yeast and its efficiency in recovery of rats from dietary iron deficiency

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