Pathways of load-induced cartilage damage causing cartilage degeneration in the knee after meniscectomy

Wilson, W.; Rietbergen, B. van; Donkelaar, Corrinus C. van; Huiskes, R.

doi:10.1016/s0021-9290(03)00004-6

Cited by 144 publications

(107 citation statements)

References 38 publications

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“…Pena et al 30 developed a 3D FE model of the knee to evaluate kinematics and mechanical behavior under physiological loads. Wilson et al 31 and Bendjaballah et al 26 considered the effect of total medial meniscectomies using the FE method, and Pena et al 32 studied the effect of total and partial medial meniscectomies.…”

Section: Journal Of Orthopaedic Research May 2006mentioning

confidence: 99%

Why lateral meniscectomy is more dangerous than medial meniscectomy. A finite element study

Peña

Calvo

Martı́nez

et al. 2006

Journal Orthopaedic Research

166

160

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Total meniscectomies are commonly thought to cause progressive degenerative arthrosis pathology in articular cartilage in a period of a few years because of alteration of the biomechanical environment including increased joint instability. This concern has lead to a preference for partial meniscectomies, although lateral partial meniscectomies sometimes lead to catastrophic results. We performed a three-dimensional finite element model of the human tibiofemoral joint to examine the effect of lateral meniscectomy on knee biomechanics. The results were compared to those from modeling a medial meniscectomy. Under axial femoral compressive loads, the peak contact stress and maximum shear stress in the articular cartilage increased 200% more after a lateral than a medial meniscectomy. These increased stresses could partly explain the higher cartilage degeneration observed after a lateral meniscectomy. ß

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Section: Journal Of Orthopaedic Research May 2006mentioning

confidence: 99%

Why lateral meniscectomy is more dangerous than medial meniscectomy. A finite element study

Peña

Calvo

Martı́nez

et al. 2006

Journal Orthopaedic Research

166

160

View full text Add to dashboard Cite

show abstract

“…For reasons of computational costs, we used a general axisymmetric model to represent the medial tibia plateau, similar to previous studies (Wilson et al 2003(Wilson et al , 2006a, rather than a more realistic three-dimensional geometry of the knee. Because we only compare simulations with the same loading and boundary conditions, we assume that this geometrical limitation does not affect our general conclusions.…”

Section: Discussionmentioning

confidence: 99%

“…Loading by the femoral condyle was simulated by using a rigid impermeable indenter with a curvature similar to the femoral condyle (Wilson et al 2003). The contact between the femur and the tibia cartilage was assumed to be frictionless.…”

Section: Simulationsmentioning

confidence: 99%

The effect of tissue-engineered cartilage biomechanical and biochemical properties on its post-implantation mechanical behavior

Khoshgoftar

Wilson

Ito

et al. 2012

Biomech Model Mechanobiol

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The insufficient load-bearing capacity of today's tissue-engineered (TE) cartilage limits its clinical application. Focus has been on engineering cartilage with enhanced mechanical stiffness by reproducing native biochemical compositions. More recently, depth dependency of the biochemical content and the collagen network architecture has gained interest. However, it is unknown whether the mechanical performance of TE cartilage would benefit more from higher content of biochemical compositions or from achieving an appropriate collagen organization. Furthermore, the relative synthesis rate of collagen and proteoglycans during the TE process may affect implant performance. Such insights would assist tissue engineers to focus on those aspects that are most important. The aim of the present study is therefore to elucidate the relative importance of implant ground substance stiffness, collagen content, and collagen architecture of the implant, as well as the synthesis rate of the biochemical constituents for the post-implantation mechanical behavior of the implant. We approach this by computing the post-implantation mechanical conditions using a composition-based fibril-reinforced poro-viscoelastic swelling model of the medial tibia plateau. Results show that adverse implant composition and ultrastructure may lead to post-implantation excessive mechanical loads, with collagen orientation being

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“…Similar to previous studies [26][27][28] , the condyle was modelled as a flattened semi-sphere of radius 20 mm, consisting of a 1 mm-deep layer of cortical bone which overlaid mature cancellous bone. The condyle was covered with a 2 mm-thick layer of cartilage which was supported by the meniscus.…”

Section: Osteochondral Defectmentioning

confidence: 99%

Unravelling the Role of Mechanical Stimuli in Regulating Cell Fate During Osteochondral Defect Repair

O'Reilly

Kelly

2016

Ann Biomed Eng

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In a previous study, we developed a computational mechanobiological model to explore the role of substrate stiffness and local oxygen availability in regulating cell fate during spontaneous osteochondral defect repair. While this model successfully simulated many aspects of the regenerative process, it was unable to predict the spatial pattern of bone formation observed during the latter stages of the repair process. The objective of this study was, therefore, to investigate the role of tissue strain in regulating the spatial and temporal patterns of stem cell differentiation during spontaneous osteochondral defect repair.Motivated by the findings of a number of prior in vitro studies, our computational mechanobiological model was updated to include rules based on the hypothesis that chondrocyte hypertrophy and endochondral ossification were inhibited in regions of high strain. The model also considered the hypothesis that excessively high magnitudes of local strain result in the formation of mechanically inferior fibrocartilage. These rules were first developed by attempting to simulate stem cell differentiation within an in vitro bioreactor system which was capable of controlling the levels of oxygen and mechanical cues within MSC-laden hydrogels. The updated model was able to predict the experimentally observed behaviour whereby the groups which were subjected to dynamic compression presented a reduction in chondrocyte hypertrophy and calcific deposition. Following this, the updated model was then used to simulate the pattern of tissue formation which had been experimentally observed during spontaneous osteochondral defect repair. As well as correctly predicting the spatial pattern of bone formation, the updated model also provided insights into the role that the mechanical environment plays on the spontaneous repair process; namely, that oxygen regulates endochondral ossification during the early phases of repair, while, during the latter stages, mechanics plays a key role in directing this process.

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Pathways of load-induced cartilage damage causing cartilage degeneration in the knee after meniscectomy

Cited by 144 publications

References 38 publications

Why lateral meniscectomy is more dangerous than medial meniscectomy. A finite element study

Why lateral meniscectomy is more dangerous than medial meniscectomy. A finite element study

The effect of tissue-engineered cartilage biomechanical and biochemical properties on its post-implantation mechanical behavior

Unravelling the Role of Mechanical Stimuli in Regulating Cell Fate During Osteochondral Defect Repair

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