Pathways to healing: Plants with therapeutic potential for neurodegenerative diseases

Tyler, Sheena E.B.; Tyler, Luke D.K.

doi:10.1016/j.ibneur.2023.01.006

Cited by 10 publications

(4 citation statements)

References 324 publications

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“…Understanding the underlying mechanisms, risk factors, and shared pathways among various neurodegenerative disorders is essential for developing targeted interventions. Recent advances in molecular and cellular neuroscience have shed light on potential therapeutic targets, opening avenues for developing neuroprotective agents to slow or halt the progression of these devastating brain disorders [16]. In this context, exploring natural compounds, such as those derived from red algae, emerges as a promising avenue for innovative therapeutic interventions in neurodegenerative diseases [17,18].…”

Section: Overview Of Neurodegenerative Disordersmentioning

confidence: 99%

Red Algae Compounds: Potential Neuroprotective Agents for Neurodegenerative Disorders

Pereira,

Valado

2024

OBM Neurobiol

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This review explores the potential of compounds derived from red algae (Rhodophyta) as promising neuroprotective agents for treating neurodegenerative disorders. Red algae, abundant in marine environments, contain bioactive compounds with diverse chemical structures and functionalities. Sulfated polysaccharides, primarily agar and carrageenans, stand out as the predominant and widely utilized compounds derived from red algae. Additionally, red algae harbor a spectrum of potential molecules such as essential fatty acids, phycobiliproteins, vitamins, minerals, and secondary metabolites. Extensive research has highlighted the diverse biological activities exhibited by these compounds, including anti-oxidative and anti-inflammatory properties. These compounds show various biological activities that have garnered interest in their therapeutic potential for neurodegenerative diseases. This comprehensive review aims to summarize the current knowledge regarding the extraction, characterization, mechanisms of action, and therapeutic applications of Rhodophyta-derived compounds in the context of neuroprotection and treatment of neurodegenerative disorders.

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Section: Overview Of Neurodegenerative Disordersmentioning

confidence: 99%

Red Algae Compounds: Potential Neuroprotective Agents for Neurodegenerative Disorders

Pereira,

Valado

2024

OBM Neurobiol

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“…Despite many attempts to develop effective therapies for neurodegenerative diseases (NDs), this group of disorders remains a leading cause of death worldwide [71], and compounds of plant origin are considered one of the most important research trends in studies on neuroprotective substances. According to ethnomedicinal data, over 1300 plants have been established to display at least one bioactivity that may have therapeutic relevance for the treatment of neurodegenerative diseases [72]. Moreover, the positive effect of cocoa polyphenols on memory and executive functions has been reported [73,74].…”

Section: Neuroprotective Effectsmentioning

confidence: 99%

Clovamide and Its Derivatives—Bioactive Components of Theobroma cacao and Other Plants in the Context of Human Health

Kolodziejczyk-Czepas

2024

Foods

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Clovamide (N-caffeoyl-L-3,4-dihydroxyphenylalanine, N-caffeoyldopamine, N-caffeoyl-L-DOPA) is a derivative of caffeic acid, belonging to phenolamides (hydroxycinnamic acid amides). Despite a growing interest in the biological activity of natural polyphenolic substances, studies on the properties of clovamide and related compounds, their significance as bioactive components of the diet, as well as their effects on human health are a relatively new research trend. On the other hand, in vitro and in vivo evidence indicates the considerable potential of these substances in the context of maintaining human health or using them as pharmacophores. The name “clovamide” directly derives from red clover (Trifolium pratense L.), being the first identified source of this compound. In the human diet, clovamides are mainly present in chocolate and other cocoa-containing products. Furthermore, their occurrence in some medicinal plants has also been confirmed. The literature reports deal with the antioxidant, anti-inflammatory, neuroprotective, antiplatelet/antithrombotic and anticancer properties of clovamide-type compounds. This narrative review summarizes the available data on the biological activity of clovamides and their potential health-supporting properties, including prospects for the use of these compounds for therapeutic purposes.

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“…album contains phenolic acids like cinnamic acid, 4-hydroxy-cinnamic acid, ferulic acid, methyl ferulate, sinapic acid, 4-hydroxybenzoic acid, 4hydroxy-3-methoxybenzoic acid, vanillic acid, mcoumaric acid, etc. 63,64 . Four of these, i.e., cinnamic acid, ferulic acid, 4-hydroxybenzoic acid and sinapic acid were used as markers for standardization of the plant and the bioactive F6 fraction.…”

Section: Histopathological Studiesmentioning

confidence: 99%

Untitled

2023

IJPSR

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Oxidative stress and cholinergic deficit are major culprits of cognitive impairment. Intake of green leafy vegetables -rich in antioxidant phytoconstituentsstrongly correlates with memory-preserving capacity. Our earlier work showed that hydromethanol (HM) extract of Chenopodium album (a common leafy vegetable) had strong acetylcholinesterase inhibitory and antioxidant activity in-vitro. The objective of the present study was to isolate the bioactive fraction/constituent from HM extract of C. album and substantiate its memory-enhancing capacity with invitro and in-vivo evidence. The HM extract was fractionated by solvent portioning and column chromatography and the antioxidant and acetylcholinesterase inhibition by fractions and sub-fractions thus obtained were assessed by DPPH and Ellman assays, respectively. The fraction F6 showed best potential in-vitro. Subsequently, the anti-amnesic capacity of HM extract and F6 was assessed using a scopolamineinduced memory impairment mouse model. Morris Water Maze test was used to determine memory. Biochemical parameters and histopathological studies of brain were also evaluated to elucidate anti-amnesic mechanism. In-vivo studies confirmed that F6 protected against scopolamine-induced memory impairment and significantly reduced brain AChE activity, oxidative stress and histopathological anomalies. The bioactive fraction (F6) of C. album exhibits marked potential to manage memory disorders via antioxidant and anticholinesterase pathways. This may be attributed to synergistic or additive effect of phenolic compounds present therein. F6 obtained from C. album can be developed as a drug or health supplement to ameliorate suffering due to memory disorders. INTRODUCTION:Dementia involves progressive decline in cognitive ability involving memory loss, communication impairment, disorientation, and impairment of a person"s ability to perform daily tasks. Many patients also display behavioral and psychological abnormalities such as psychosis, irritation, mood disorders, depression, etc 1, 2 . This causes immense suffering to the patient and is an economic and emotional burden on the caregivers.

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Pathways to healing: Plants with therapeutic potential for neurodegenerative diseases

Cited by 10 publications

References 324 publications

Red Algae Compounds: Potential Neuroprotective Agents for Neurodegenerative Disorders

Red Algae Compounds: Potential Neuroprotective Agents for Neurodegenerative Disorders

Clovamide and Its Derivatives—Bioactive Components of Theobroma cacao and Other Plants in the Context of Human Health

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