Since 1999, the Kansas K-12 Initiative has generated almost $21 million from university, school district, private foundations, and federal sources to support the development of multiple STEM programs in Kansas City, Kansas. Program goals were to engage urban minority youth in STEM education, increase college readiness, and provide motivation for STEM careers. Over the 20-year period, these programs had 3,547 participants. Ninety percent of program graduates were racial and ethnic minorities. Almost all seniors (98% on average) enrolled in college, and 70% of students who declared a major, declared a STEM major. Programmatic findings demonstrate that STEM programming is widely supported, feasible, and effective on the measure of post-secondary education matriculation. This program description highlights the necessary evolution of programming over two decades with multiple funding sources, giving insight into sustained partnerships, commitment of staff, and long-term engagement of students.