Patient acceptance of non-invasive testing for fetal aneuploidy via cell-free fetal DNA

Vahanian, Sevan A.; Allaf, M. Baraa; Yeh, Corinne; Chavez, Martin; Kinzler, Wendy L.; Vintzileos, Anthony M.

doi:10.3109/14767058.2013.806477

Cited by 20 publications

(23 citation statements)

References 5 publications

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“…These latter three studies (Chetty et al, 2013;Taylor et al, 2014;Vahanian et al, 2014) provide extensive information regarding how factors such as insurance and race influence patient uptake, but they did not survey women on the reasons they declined (Taylor et al, 2014). To our knowledge, ours is the first report to address the underlying reasons patients provide for their decision-making.…”

Section: Discussionmentioning

confidence: 97%

“…Other studies have examined ccfDNA test uptake in the high-risk setting, either through preference surveys (Hill et al, 2012;Carroll et al, 2013) or by experience (Chetty et al, 2013;Taylor et al, 2014;Vahanian et al, 2014). These latter three studies (Chetty et al, 2013;Taylor et al, 2014;Vahanian et al, 2014) provide extensive information regarding how factors such as insurance and race influence patient uptake, but they did not survey women on the reasons they declined (Taylor et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Maternal Plasma DNA Testing: Experience of Women Counseled at a Prenatal Diagnosis Center

O’Brien

Kloza²,

Halliday³

et al. 2014

Genetic Testing and Molecular Biomarkers

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Maternal Plasma DNA Testing: Experience of Women Counseled at a Prenatal Diagnosis Center

O’Brien

Kloza²,

Halliday³

et al. 2014

Genetic Testing and Molecular Biomarkers

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show abstract

“…Several studies have documented the impact on invasive procedures and karyotyping. [5][6][7] However, this is the first study aimed at determining whether DNA testing is impacting the high rate of serum screening in the United States, relying on three independent data sets that examine changes in proportions of women receiving serum screening before and after DNA testing was offered or recommended. An ongoing nationwide survey of screening laboratories found that there was an increase in overall serum screening of 5% between 2011 and 2013.…”

Section: Discussionmentioning

confidence: 99%

Is maternal plasma DNA testing impacting serum-based screening for aneuploidy in the United States?

Palomaki

Ashwood

Best

et al. 2015

Genetics in Medicine

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“…Indeed, NIPT could become a 'reproductive strategy' that is available to a privileged portion of the population, allowing certain parents to 'choose' the best genetic characteristics for their children [29]. In a study performed by Yotsumoto and colleagues to assess pregnant women and health professionals' attitudes toward NIPT, pregnant women expressed worries about the possibility of unequal access to NIPT due to its high cost, especially in a context where it would be offered by private companies and not covered by public funding [62,74]. The ELSI literature has frequently called for policies that support equity in access to NIPT in various countries [5,75].…”

Section: The Implementation Of Niptmentioning

confidence: 99%

Non-Invasive Prenatal Testing: Review of Ethical, Legal and Social Implications

Haidar

Dupras

Ravitsky

2018

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Droits d'auteur © H Haidar, C Dupras et V Ravitsky, 2016Ce document est protégé par la loi sur le droit d'auteur. L'utilisation des services d'Érudit (y compris la reproduction) est assujettie à sa politique d'utilisation que vous pouvez consulter en ligne.https://apropos.erudit.org/fr/usagers/politique-dutilisation/ Cet article est diffusé et préservé par Érudit.Érudit est un consortium interuniversitaire sans but lucratif composé de l'Université de Montréal, l'Université Laval et l'Université du Québec à Montréal. Il a pour mission la promotion et la valorisation de la recherche. Non-invasive prenatal testing (NIPT) using cell-free fetal DNA (cffDNA) from maternal blood has recently entered clinical practice in many countries, including Canada. This test can be performed early during pregnancy to detect Down syndrome and other conditions. While NIPT promises numerous benefits, it also has challenging ethical, legal and social implications (ELSI). This paper reviews concerns currently found in the literature on the ELSI of NIPT. We make four observations. First, NIPT seems to exacerbate some of the already existing concerns raised by other prenatal tests (amniocentesis and maternal serum screening) such as threats to women's reproductive autonomy and the potential for discrimination and stigmatization of disabled individuals and their families. This may be due to the likely upcoming large scale implementation and routinization of NIPT. Second, the distinction between NIPT as a screening test (as it is currently recommended) and as a diagnostic test (potentially in the future), has certain implications for the ELSI discussion. Third, we observed a progressive shift in the literature from initially including mostly conceptual analysis to an increasing number of empirical studies. This demonstrates the contribution of empirical bioethics approaches as the technology is being implemented into clinical use. Finally, we noted an increasing interest in equity and justice concerns regarding access to NIPT as it becomes more widely implemented. Mots clés Keywords Exonération DisclaimerLes évaluations des examinateurs externes sont prises en considération de façon sérieuse par les éditeurs et les auteurs dans la préparation des manuscrits pour publication. Toutefois, être nommé comme examinateur n'indique pas nécessairement l'approbation du manuscrit par cet examinateur. Les éditeurs de BioéthiqueOnline assument la responsabilité entière pour l'acceptation finale et la publication d'un article.Reviewer evaluations are given serious consideration by the editors and authors in the preparation of manuscripts for publication. Nonetheless, being named as a reviewer does not necessarily denote approval of a manuscript by the reviewer; the editors of BioéthiqueOnline take full responsibility for final acceptance and publication of an article.

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Patient acceptance of non-invasive testing for fetal aneuploidy via cell-free fetal DNA

Abstract: In our population, having public insurance was the factor most strongly associated with declining noninvasive prenatal testing.

Cited by 20 publications

References 5 publications

Maternal Plasma DNA Testing: Experience of Women Counseled at a Prenatal Diagnosis Center

Maternal Plasma DNA Testing: Experience of Women Counseled at a Prenatal Diagnosis Center

Is maternal plasma DNA testing impacting serum-based screening for aneuploidy in the United States?

Non-Invasive Prenatal Testing: Review of Ethical, Legal and Social Implications

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