Patient adherence to HIV medication regimens: a review of published and abstract reports

Fogarty, Linda; Roter, Debra; Larson, Susan; Burke, Jessica G.; Gillespie, Jeanne L.; Levy, R

doi:10.1016/s0738-3991(01)00219-1

Cited by 319 publications

(266 citation statements)

References 20 publications

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“…There are a number of personal and social factors that have been identified as possible factors in ART adherence (Ammassari et al 2002;Fogarty et al 2002;Ickovics et al 2002). In order to create a realistic model for testing, we used a systematic method to select the most salient variables to include in the model using social cognitive theory (SCT) as the guiding framework.…”

Section: Theoretical Perspectivementioning

confidence: 99%

“…Inadequate or inconsistent medication intake is a concern for health care providers, who are aware of the side effects and lifestyle changes required for their patients to take these medications. Research shows that medication-taking difficulties can be due to medication-related factors such as pill burden, side effects, and complicated regimens (Bartlett et al 2001;Fogarty et al 2002;. As new generations of drugs become available, pharmaceutical companies are addressing these concerns by developing pills that include more than one drug and regimen schedules that offer once or twice per day dosing with fewer and smaller pills.…”

Section: Introductionmentioning

confidence: 99%

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Adherence to Antiretroviral Medication Regimens: A Test of a Psychosocial Model

et al. 2007

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Objective-The primary aim of this study was to test a psychosocial model of medication adherence among people taking antiretroviral medications. This model was based primarily on social cognitive theory and included personal (self-efficacy, outcome expectancy, stigma, depression, and spirituality), social (social support, difficult life circumstances), and provider (patient satisfaction and decision-making) variables. © Springer Science+Business Media, LLC 2007Correspondence to: Colleen DiIorio, cdiiori@sph.emory.edu. Design-The data for this analysis were obtained from the parent study, which was a randomized controlled trial (Get Busy Living) designed to evaluate an intervention to foster medication adherence. Factor analysis was used to develop the constructs for the model, and structural equation modeling was used to test the model. Only baseline data were used in this cross sectional analysis. NIH Public AccessMethods-Participants were recruited from a HIV/AIDS clinic in Atlanta, GA. Prior to group assignment, participants were asked to complete a questionnaire that included assessment of the study variables.Results-A total of 236 participants were included in the analysis. The mean age of the participants was 41 years; the majority were male, and most were African-American. In the final model, self-efficacy and depression demonstrated direct associations with adherence; whereas stigma, patient satisfaction, and social support were indirectly related to adherence through their association with either self-efficacy or depression.Conclusion-These findings provide evidence to reinforce the belief that medication-taking behaviors are affected by a complex set of interactions among psychosocial variables and provide direction for adherence interventions.

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Section: Theoretical Perspectivementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Adherence to Antiretroviral Medication Regimens: A Test of a Psychosocial Model

et al. 2007

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“…Research has demonstrated that HIV-positive substance users have difficulty adhering to complex highly active antiretroviral therapy (HAART) regimens, particularly when they are actively using substances (Batki and Ferrando, 1996;Freeman et al, 1996;Fogarty et al, 2002). Cocaine use is associated with a 41% decline in median antiretroviral adherence and is a strong predictor of failure to maintain viral load (Arnsten et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Voucher reinforcement improves medication adherence in HIV-positive methadone patients: A randomized trial

Sorensen

Haug

Delucchi

et al. 2007

Drug and Alcohol Dependence

145

136

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This clinical trial evaluated a contingency management intervention designed to improve medication adherence among HIV-positive methadone maintenance patients. After a 4-week baseline observation phase, eligible participants (N = 66) were randomly assigned to: (a) medication coaching sessions every other week to assist with adherence strategies (comparison group) or (b) medication coaching plus voucher reinforcement for opening electronic medication caps on time (voucher group). Baseline adherence (percent doses taken/percent total possible doses) was 51% using electronic measurement, 75% using self-report and 75% using pill count. The intervention was provided for 12 weeks, with a 4-week follow-up. The primary outcome results of the clinical trial indicated effectiveness during the intervention, with significant mean adherence differences between voucher and comparison groups using electronic measurement (78% vs. 56%), pill count (86% vs. 75%), and self-report (87% vs. 69%). Differences between groups faded after vouchers were discontinued. Contingency management shows promise as a strategy to promote antiretroviral medication adherence in this population.

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“…There is some evidence that adherence correlates with a patient's belief in the severity of the disease to be prevented or treated, 23,40,41 thus one would expect all cancer patients to adhere. Patient perceptions about their illness strongly influenced adherence in cancer patients, consequently affecting the patients' motivation, and ultimately, the ability of the oral antineoplastic agents to effectively manage the disease.…”

Section: Beliefs About Treatment and Outcome Expectationmentioning

confidence: 99%