Patient adherence to prescribed artemisinin-based combination therapy in Garissa County, Kenya, after three years of health care in a conflict setting

Gore-Langton, Georgia R.; Alenwi, Nfornuh; Mungai, James; Erupe, Nahashon I; Eves, Katie; Kimwana, Francis Njoroge; Soti, David; Akhwale, Willis; Hassan, Farah Amin; Juma, Elizabeth; Allan, Richard

doi:10.1186/s12936-015-0645-z

Cited by 14 publications

(16 citation statements)

References 23 publications

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“…19 The study finding is also in agreement with the findings of Amponsah et al, Gore-Langton et al, Yeung and White, where they reported low adherence level to antimalarial medications. [29][30][31] The current study finding disagrees with Aung et al, where (85.7%) of respondents in Rakhine State, Myanmar were classified as probably adherent, and 23 (14.3%) as non-adherent group. 2 Also, the study finding is not in accordance with Fogg et al where they reported high adherence to the combination of Artemether and Lumefantrine in Uganda in which 90% of the children were documented as being probably adherent, 7.1% being definitely non-adherent.…”

Section: Discussioncontrasting

confidence: 99%

Patients’ adherence to antimalarial medication; self-report of patients at the Volta regional hospital of Ho, Ghana

et al. 2017

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Background: Despite the advancement in malaria treatments and management; malaria morbidity and mortality is still on the increase. This phenomenon has been mostly attributed to the emergence and transmission resistance of the plasmodium parasite to drugs; which is as a result of non-adherence to anti-malaria medication. Therefore, the purpose of this study was to assess patients’ adherence to anti-malarial medications and the factors influencing their adherence in the Volta regional hospital.Methods: A descriptive cross-sectional study was employed. Convenience sampling technique was used in recruiting respondents. Data were collected within a period of 8 weeks from April to May 2017. Data were analyzed using descriptive statistics in the form of frequencies, percentages, mean and standard deviations which was generated by the use of IBM statistical package for social sciences version 23.Results: The average age of respondents surveyed for this study was 32.27±11.09 ranging from of 19 to 68 years. Majority (51.7%) of respondents were females and 76.7% of them being Christians. The study findings revealed that 36.6% of patient were completely adherent to anti-malarial medication. Over 90% of respondents agreed that the malarial medication had bad taste and it was an unpleasant feeling for them taking it.Conclusions: Poor adherence to antimalaria medications could play a role in the future development of drug resistance. As such, identifying ways to improve anti-malarial compliance will help mitigate drug resistance. Therefore, further studies should be carried out on ways to improve patients’ adherence to antimalarial medication.

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Section: Discussioncontrasting

confidence: 99%

Patients’ adherence to antimalarial medication; self-report of patients at the Volta regional hospital of Ho, Ghana

et al. 2017

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“…The results showed that there was no signi cant relationship between patients demographics and their compliance with antimalarial drugs treatment and that was consistent with the ndings of a study carried out in Uganda [28]. Stopping treatment after symptoms improvement [29] and upon the development of ADRs [30] was shown in some studies and it was found that drug knowledge and previous experience of drug use were signi cant predictors of adherence to treatment [31]. Patient education on noncompliance to treatment and its drawbacks not only for the patients but also for the whole country as a risk of drug resistance is very crucial.…”

Section: Discussionsupporting

confidence: 83%

Publics’ Malaria Knowledge, Prevention and Treatment Practices, A Cross-sectional Survey From Khartoum, Sudan

Sulaiman

elhag

2020

Preprint

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Background: Malaria is one of the major health problems in Sudan with high prevalence among children under five years age and pregnant women. Effective control of the disease needs contribution of the community, health authorities as well as political commitment. This research was conducted to assess the public’s knowledge, and practice regarding malaria prevention and treatment.Methods: A cross-sectional survey was conducted among publics in Khartoum State. Data was collected using a self-administered questionnaire. Publics were assessed for their knowledge about malaria symptoms and complications, knowledge and utilization of prevention methods and drugs knowledge and treatment behaviors.Results: About 457 of the public participated in the survey. Despite that the publics showed good knowledge regarding malaria symptoms, complications and drugs knowledge, self-treatment practices were there. Noncompliance to treatment in form of stopping treatment upon symptoms relieve and upon developing adverse drug reactions was also reported. Underuse of prevention methods was reported.Conclusions: Inappropriate treatment and prevention practices among the community could be an obstacle in the way of malaria elimination in Sudan. More efforts towards involvement of the community in malaria control through community education are needed.

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“…When meta-analysis was restricted to the eighteen studies (and two sub-studies) [12, 22, 24, 25, 28–31, 34–40, 42, 43, 45] that administered AL, the REM pooled prevalence of adherence (95% CI) was 70.52% (60.82%–80.22%). No publication was detected (Begg's test P value = 0.056 and Egger's test P value = 0.018).…”

Section: Resultsmentioning

confidence: 99%

Adherence to Artemisinin-Based Combination Therapy for the Treatment of Uncomplicated Malaria: A Systematic Review and Meta-Analysis

Yakasai¹,

Hamza

Dalhat

et al. 2015

Journal of Tropical Medicine

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Adherence to artemisinin-based combination therapy (ACT) is not clearly defined. This meta-analysis determines the prevalence and predictors of adherence to ACT. Twenty-five studies and six substudies met the inclusion criteria. The prevalence of ACT adherence in the public sector was significantly higher compared to retail sector (76% and 45%, resp., P < 0.0001). However, ACT adherence was similar across different ACT dosing regimens and formulations. In metaregression analysis prevalence estimates of adherence significantly decrease with increasing year of study publication (P = 0.046). Factors found to be significant predictors of ACT adherence were years of education ≥ 7 {odds ratio (OR) (95% CI) = 1.63 (1.05–2.53)}, higher income {2.0 (1.35–2.98)}, fatty food {4.6 (2.49–8.50)}, exact number of pills dispensed {4.09 (1.60–10.7)}, and belief in traditional medication for malaria {0.09 (0.01–0.78)}. The accuracy of pooled estimates could be limited by publication bias, and differing methods and thresholds of assessing adherence. To improve ACT adherence, educational programs to increase awareness and understanding of ACT dosing regimen are interventions urgently needed. Patients and caregivers should be provided with an adequate explanation at the time of prescribing and/or dispensing ACT.

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Patient adherence to prescribed artemisinin-based combination therapy in Garissa County, Kenya, after three years of health care in a conflict setting

Cited by 14 publications

References 23 publications

Patients’ adherence to antimalarial medication; self-report of patients at the Volta regional hospital of Ho, Ghana

Patients’ adherence to antimalarial medication; self-report of patients at the Volta regional hospital of Ho, Ghana

Publics’ Malaria Knowledge, Prevention and Treatment Practices, A Cross-sectional Survey From Khartoum, Sudan

Adherence to Artemisinin-Based Combination Therapy for the Treatment of Uncomplicated Malaria: A Systematic Review and Meta-Analysis

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