Patient Age and CYP2D6*4/CYP2D6*3 Genotype on Maximal Heart Rate in Patients after Acute Coronary Syndrome Treated with Bisoprolol

Shumkov, V A; Zagorodnikova, Ksenia; Болдуева, С. А.; Murzina, A. A.; Petrova, V B

doi:10.1134/s2079057021040135

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…And these physical impairments are now seriously affecting their health. In relevant studies, the physical fitness of primary and secondary school students in China has been comprehensively tested, and continuous research has been carried out on each stage of establishing the index system [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Study on Maximal Oxygen Uptake of Respiration and Heart Rate in Exercise Training Based on Regression Equation

Liang

2022

Journal of Healthcare Engineering

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To investigate the important index of maximum oxygen uptake in evaluating cardiopulmonary function and to provide a basis for the evaluation of cardiopulmonary function for adolescents, a total of 200 healthy adolescents aged 12–14 were selected, and these 200 subjects were randomly assigned to the modeling group and the test group. In the first stage, data of 150 subjects were randomly selected, and the regression equation for VO2max was established by adding independent variables such as gender, age, height, weight, body mass index, and resting heart rate. In the second stage, the remaining 50 subjects were selected as the test group to test and evaluate the prediction effect of the prediction model. The results showed that the correlation coefficient between the measured value of maximal oxygen uptake and the predicted value was 0.983, and the significance level was 0.000, which was significantly lower than 0.01 correlation, indicating that there was an obvious concomitant relationship between the two values. The maximum oxygen uptake calculated by this equation is good and has a good application prospect.

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Section: Introductionmentioning

confidence: 99%

Study on Maximal Oxygen Uptake of Respiration and Heart Rate in Exercise Training Based on Regression Equation

Liang

2022

Journal of Healthcare Engineering

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Impact of CYP2D62A, CYP2D64 and CYP3A5*3 genetic polymorphisms on Bisoprolol peak concentration and clinical response in acute coronary syndrome patients

Okda,

El‐Bassiouny,

El Amrawy

et al. 2024

Brit J Clinical Pharma

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AimsAcute coronary syndrome (ACS) represents a major cause of death. Bisoprolol is commonly used in the management of ACS. This study aims to investigate the impact of CYP2D6*2A, CYP2D6*4 and CYP3A5*3 genetic polymorphisms on pharmacokinetics and clinical response of bisoprolol in ACS patients.MethodsThis is an open‐label cohort study that included 127 ACS patients and studied the effect of CYP3A5*3, CYP2D6*2A and CYP2D6*4 genotyping using real‐time polymerase chain reaction on steady state bisoprolol plasma peak concentration analysed by high performance liquid chromatography–fluorescence detector.ResultsRegarding CYP3A5*3, the mean peak bisoprolol concentration for CC, CT and TT genotypes were 4.25 ± 1.20, 3.93 ± 1.10 and 1.79 ± 0.69 ng/mL, respectively (P < .001). Higher systolic (126 ± 5.47 mmHg), diastolic blood pressure (82 ± 2.73 mmHg) and heart rate (97.80 ± 3.03 beats/min) were also observed in CYP3A5*3 TT carriers (P < .05). In CYP2D6*2A, the peak concentration of bisoprolol was lower in CC carriers (3.54 ± 1 ng/mL) compared to GG (4.38 ± 1.25 ng/mL) and GC carriers (4.07 ± 1.29 ng/mL, P = .019). In CYP2D6*4, the mean bisoprolol peak concentration in CC carriers was 3.98 ± 1.31 ng/mL, which was lower than T allele carriers (4.5 ± 0.8, P = .02). No differences in heart rate, systolic, diastolic blood pressure or bisoprolol dose were observed among CYP2D6*2A or CYP2D6*4 variants. Smokers exhibited lower bisoprolol peak concentration (3.96 ± 1.2 ng/mL) compared to nonsmokers (4.55 ± 1.34 ng/mL, P = .037).ConclusionThere is an association between CYP3A5*3, CYP2D6*4, CYP2D6*2A variants and bisoprolol peak concentration, which may serve as a guide in the future in choosing the optimum dose of bisoprolol in ACS patients.

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Patient Age and CYP2D64/CYP2D63 Genotype on Maximal Heart Rate in Patients after Acute Coronary Syndrome Treated with Bisoprolol

Cited by 2 publications

References 19 publications

Study on Maximal Oxygen Uptake of Respiration and Heart Rate in Exercise Training Based on Regression Equation

Study on Maximal Oxygen Uptake of Respiration and Heart Rate in Exercise Training Based on Regression Equation

Impact of CYP2D62A, CYP2D64 and CYP3A5*3 genetic polymorphisms on Bisoprolol peak concentration and clinical response in acute coronary syndrome patients

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Patient Age and CYP2D6*4/CYP2D6*3 Genotype on Maximal Heart Rate in Patients after Acute Coronary Syndrome Treated with Bisoprolol

Cited by 2 publications

References 19 publications

Study on Maximal Oxygen Uptake of Respiration and Heart Rate in Exercise Training Based on Regression Equation

Study on Maximal Oxygen Uptake of Respiration and Heart Rate in Exercise Training Based on Regression Equation

Impact of CYP2D6*2A, CYP2D6*4 and CYP3A5*3 genetic polymorphisms on Bisoprolol peak concentration and clinical response in acute coronary syndrome patients

Contact Info

Product

Resources

About

Patient Age and CYP2D64/CYP2D63 Genotype on Maximal Heart Rate in Patients after Acute Coronary Syndrome Treated with Bisoprolol

Impact of CYP2D62A, CYP2D64 and CYP3A5*3 genetic polymorphisms on Bisoprolol peak concentration and clinical response in acute coronary syndrome patients