Patient age and positive margins are predictive factors of residual tumor on mastectomy specimen after conservative treatment for breast cancer

Voguet, Laure; Hébert, Thomas P.; Lévèque, Jean; Acker, Olivier; Mesbah, H.; Marret, H.; Porée, Philippe; Body, G.

doi:10.1016/j.breast.2009.06.002

Cited by 14 publications

(8 citation statements)

References 31 publications

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“…19 Young age, Residual Disease After Wide Local Excision often defined as < 40 years, has also been cited as a risk factor for positive margins and residual disease. 12, 15 We did not observe such an association, although the effect of age might not have been reliably evaluated because only 50 of the 720 women (7%) in our study were < 40 years old. In addition, compared with most Western countries, many more women in Singapore, even those in the younger age groups, will choose mastectomy instead of breastconserving therapy (unpublished data).…”

Section: Residual Disease After Wide Local Excisionmentioning

confidence: 49%

“…Ipsilateral breast tumor recurrence increases by at least twofold when the surgical margins are involved by tumor. 5,13,14 Positive margins signify a significant possibility of residual disease around the resection bed, 15 which can persist despite adjuvant treatment, because radiation and systemic treatment have failed to negate the greater local failure rates. 16,17 As a corollary of this, reoperation has been recommended whenever the initial resection has been deemed inadequate.…”

Section: Salim Alrahbi Et Almentioning

confidence: 99%

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Extent of Margin Involvement, Lymphovascular Invasion, and Extensive Intraductal Component Predict for Residual Disease After Wide Local Excision for Breast Cancer

Al-Rahbi

Chan

et al. 2015

Clinical Breast Cancer

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Section: Residual Disease After Wide Local Excisionmentioning

confidence: 49%

Section: Salim Alrahbi Et Almentioning

confidence: 99%

Extent of Margin Involvement, Lymphovascular Invasion, and Extensive Intraductal Component Predict for Residual Disease After Wide Local Excision for Breast Cancer

Al-Rahbi

Chan

et al. 2015

Clinical Breast Cancer

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“…Breast cancer patients with the same clinical prognostic profile may have markedly different outcomes, which are concrete manifestations of distinct molecular biology behavior [ 21 ]. Traditional clinicopathological parameters including positive margin, vascular tumor invasion, histological grade, lymph node staging and tumor size have been verified as independent risk factors for recurrence [ 22 – 27 ]. NPI combines the number of involved lymph nodes, tumor size and histological grade to determine prognosis, it is a well-established clinicopathological score system which offers comprehensive prognostic information than single marker [ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Correlation analysis between molecular subtypes and Nottingham Prognostic Index in breast cancer

Zhen

Yang

et al. 2017

Oncotarget

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Molecular subtypes and Nottingham Prognostic Index (NPI) are both prognostic models for breast cancer patients. We evaluated the association between molecular subtypes and NPI in 1042 breast cancer patients. The molecular subtypes indicating poorer prognosis were positively correlated to higher NPI (r = 0.138, P = 0.001). ER positive expression and PR high expression were positively correlated with NPI (r = 0.142, P = 0.001; r = 0.139, P = 0.001; respectively) and negatively correlated with histological grade (r = −0.233, P < 0.001; r = −0.176, P < 0.001; respectively). Ki67 status was negatively correlated with NPI and positively correlated with histological grade (r = −0.120, P =0.004; r = 0.197, P < 0.001; respectively). The percentages of cases with NPI score 2.00–3.40 were higher in the luminar A, ER+, PR high expression and Ki67 low expression group, and the percentages of cases with NPI > 5.40 were higher in the HER2 overexpression subtype, basal-like subtype, ER-, PR low/negative expression, and Ki67 high expression groups. The excellent consistence was observed between histological grade and molecular subtypes, ER, PR, Ki67. The difference of histological grade between the HER2 positive and negative group was statistically significant. In conclusion, there was closely association between molecular subtypes and NPI in breast cancer. For further comparing the prognostic significance of molecular subtypes and NPI, survival analyses should be performed on the same population in a large-scale prospective study.

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“…Rational analysis of pathological characteristics is useful for judging the prognosis of patients with breast cancer. Traditional pathological markers including node staging, 2 3 positive margin, 4 5 vascular tumour invasion, 6 differentiation grade 3 7 and lymph vessel tumour embolus grade 3 8 have been verified as independent risk factors for the recurrence and prognosis. Oestrogen receptor (ER) and progesterone receptor (PR) have been included in routine pathological practice, and are used to predict the patients’ course of disease and response to adjuvant hormonal therapy.…”

Section: Introductionmentioning

confidence: 99%

Characteristics and prognostic values of traditional pathological parameters and advanced molecular subtypes in women in Beijing with operable breast cancer: a retrospective analysis

Jiang

et al. 2018

BMJ Open

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ObjectivesThis study investigated the characteristics and prognostic values of traditional pathological parameters and advanced molecular subtypes in women with operable breast cancer in Beijing.DesignA retrospective study through case information enquiry or telephonic follow-up.SettingBeijing Friendship Hospital.Participants1042 patients with primary operable breast cancer between 2008 and 2012 were enrolled in the study.MeasuresThe characteristics and 5-year relapse rates according to the Nottingham Prognosis Index (NPI) and molecular subtypes were analysed.ResultsIn 1042 patients, the percentages of high histological grade, N1+N2, T2+T4 were 7.3%, 24.2%, 46.9%, respectively. In patients with invasive breast cancer, the percentages of auxiliary staging, positive margins, vascular invasion and nerve infiltration were 65.0%, 2.8%, 10.5% and 1.1%, respectively. The missing percentages of auxiliary staging, margins, vascular tumour invasion and nerve infiltration were 14.2%, 31.4%, 46.5% and 97.4%, respectively. The percentages of ER-positive, PR-positive, HER2-positive and Ki-67 high expression were 64.3%, 43.8%, 18.8% and 62.7%, respectively. The percentages of luminal A, luminal B, HER2-overexpression and basal-like breast cancers were 10.5%, 54.2%, 8.2% and 11.2%, respectively. Luminal A, luminal B and basal-like breast cancer subtypes were more common in the >60 years group, the 41–60 years group and the 20–40 years group, respectively. The 5-year relapse rates according to NPI were as follows: 6.2% in the low recurrence risk group, 10.4% in the moderate recurrence risk group and 12.9% in the high recurrence risk group. The 5-year relapse rates according to molecular subtypes were as follows: luminal A 4.0%, luminal B 7.0%, HER2-overexpression14.2%, basal-like 15.6%.ConclusionsReasonable analysis of traditional pathological parameters and advanced molecular subtypes in women with operable breast cancer in Beijing may be useful to guide precise treatment and predict prognosis.

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Patient age and positive margins are predictive factors of residual tumor on mastectomy specimen after conservative treatment for breast cancer

Abstract: Young age of patients (under 45-years-old) and presence of positive margins on the operative specimen are independent risk factors of residual tumor after conservative treatment of breast cancer.

Cited by 14 publications

References 31 publications

Extent of Margin Involvement, Lymphovascular Invasion, and Extensive Intraductal Component Predict for Residual Disease After Wide Local Excision for Breast Cancer

Extent of Margin Involvement, Lymphovascular Invasion, and Extensive Intraductal Component Predict for Residual Disease After Wide Local Excision for Breast Cancer

Correlation analysis between molecular subtypes and Nottingham Prognostic Index in breast cancer

Characteristics and prognostic values of traditional pathological parameters and advanced molecular subtypes in women in Beijing with operable breast cancer: a retrospective analysis

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