Patient Age and Success in a Human IVF Programme

Abstract

Previous studies suggest that at around 40 years of age, pregnancy rates achieved by IVF programmes fall and pregnancy loss rates increase. The actual age at which this occurs has not been clearly delineated. This study of 2,692 patients including 94 aged 41 or over shows that satisfactory pregnancy rates can be achieved up to and including age 40. As age 40 is approached the pregnancy loss rate increases to around 40%. In the 41 years and over group the pregnancy rate was poor at 6% (6/94) and the pregnancy loss rate very discouraging at 83% (5/6).

Meta‐analysis of the embryo freezing transfer interval

“…Since the studies reviewed were not randomized, we performed a separate analysis of three of the most important prognostic factors in IVF, namely maternal age, 57,58 the number of oocytes retrieved, 59 and the number of embryos transferred 60,61 . All of them were very similar in the immediate and delayed transfer groups, and hence, these were ruled out as confounding factors.…”

Pharmacokinetics, safety, and tolerability of Pentoxifylline intravaginal gel for subfertile/ infertile couples with low sperm quality: phase I randomized controlled clinical trial in healthy women

“…The miscarriage rate in women aged more than 35 years was 2.4%. [Evidence level 3] These data were based on numbers of pregnancies shown in Table11.3 and they give miscarriage rates per pregnancy of 10.5% at 30 years, 13.1% at 35 years, 22.7% at 40 years, and 40.7% at 43 years.Several other studies have reported increased miscarriage rates following IVF in women aged more than 34 years,726 35 years 755,757,769 and 40 years 758,759,762,…”

“…[Evidence level 3]A cohort study has shown that pregnancy rates decline significantly after the age of 40 years, and again after the age of 42 years 753. [Evidence level 2b]Several other studies have shown that pregnancy rates following IVF treatment decline after the age of 35 years,[754][755][756][757] 37 years 758 and 40 years 334,[724][725][726][759][760][761][762][763].…”