Patient- and Tumour-related Prognostic Factors for Urinary Incontinence After Radical Prostatectomy for Nonmetastatic Prostate Cancer: A Systematic Review and Meta-analysis

Lardas, Michael; Grivas, Nikos; Debray, Thomas P A; Zattoni, Fabio; Berridge, Christopher; Cumberbatch, Marcus; Broeck, Thomas Van den; Briers, Erik; Santis, Maria De; Farolfi, Andrea; Fossati, Nicola; Gandaglia, Giorgio; Gillessen, Silke; O’Hanlon, Shane; Henry, Ann; Liew, Matthew; Mason, Malcolm David; Moris, Lisa; Oprea-Lager, Daniela E.; Ploussard, Guillaume; Rouvière, Olivier; Schoots, Ivo G.; Kwast, Theodorus van der; Poel, Henk van der; Wiegel, Thomas; Willemse, Peter‐Paul M.; Yuan, Yuhong; Grummet, Jeremy; Tilki, Derya; Bergh, Roderick C.N. van den; Lam, Thomas; Cornford, Philip; Mottet, Nicolas

doi:10.1016/j.euf.2021.04.020

Cited by 37 publications

(32 citation statements)

References 129 publications

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“…Similar to our study, Wolin et al suggested that obese subjects had a higher incontinence rate after RP than normal subjects and patients who were overweight and lacked physical activity were more likely to delay the recovery of urinary continence (7). However, other studies believed that BMI did not affect the risk of postoperative urinary incontinence (6). Therefore, the effect of BMI on urinary continence recovery after RP is still unclear and needs further investigation.…”

Section: Discussionsupporting

confidence: 73%

“…The range of continence rates at 12 months after RP was 89%-97.9%, which was similar and stable (3). The factors mainly affecting long-term urinary continence included age, BMI, prostate volume and MUL (6). Long-term urinary continence after RP was fully investigated in previous studies, but there were few studies focusing on the IUC recovery.…”

Section: Discussionmentioning

confidence: 99%

“…Due to the standardization of RP procedures, changes in surgical approaches, and improvement of surgical reconstruction, the recovery rate of urinary continence after RP has been reported to increase (4). Several preoperative patients' demographic characteristics, including old age (5,6) and obesity which equals to higher body mass index (BMI) (6,7), larger prostate volume (6,7), and severe lower urinary tract symptom (6,8) have been proposed to be related to post-prostatectomy urinary incontinence. Moreover, preoperative pelvic and urethral anatomic parameters measured on MRI, such as membranous urethral length (MUL) (6, 9, 10) and intravesical prostatic protrusion length (IPPL) (11,12), have also been demonstrated to be associated with the recovery of urinary continence.…”

Section: Introductionmentioning

confidence: 99%

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The development and assessment of a predicting nomogram for the recovery of immediate urinary continence following laparoscopic radical prostatectomy

Zheng²,

Zhang³

et al. 2023

Front. Surg.

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PurposeThis study aimed to develop a nomogram to predict the recovery of immediate urinary continence in laparoscopic radical prostatectomy (LRP) patients.MethodsA prediction model was developed based on a dataset of 154 LRP patients. Immediate urinary continence was defined as free from using pads within 7 days after the removal of the urinary catheter. The least absolute shrinkage and selection operator regression (LASSO) model was applied to screen the features. Multivariate logistic regression analysis was used to establish prediction model integrating the features selected from the LASSO regression analysis. Receiver operating curve (ROC), calibration and decision curve analysis (DCA) were used to assess the model's discrimination, calibration and clinical utility.ResultsThe identified features of the prediction model included age, body mass index (BMI) and three pelvic anatomic parameters measured by MRI: membranous urethral length (MUL), intravesical prostatic protrusion length (IPPL) and puborectalis muscle width (PMW). The nomogram showed good discrimination with an are under the curve(AUC) of 0.914 (95% CI, 0.865–0.959, p < 0.001). Moreover, good calibration was showed in the model. Lastly, DCA showed that the nomogram was clinically useful.ConclusionThe developed novel nomogram that can predict the possibility for post-prostatectomy patients to recover immediate urinary continence could be used as a counseling tool to explain urinary incontinence to patients after LRP.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The development and assessment of a predicting nomogram for the recovery of immediate urinary continence following laparoscopic radical prostatectomy

Zheng²,

Zhang³

et al. 2023

Front. Surg.

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“…To date, about 50 studies studied the relationship between MUL and post-prostatectomy incontinence. Several meta-analyses confirmed the predictive power of this parameter [ 4 , 12 , 15 ]. A recent systematic review and meta-analysis showed the significant relation between the MUL and the extent of urinary incontinence at 1, 3, 6 and 12 months after radical prostatectomy [ 4 ].…”

Section: Anatomical Parameters To Predict Urinary Continence After Ra...mentioning

confidence: 90%

“…Several patient-related factors are known to influence risk of urinary incontinence, such as age, pre-existing lower urinary tract symptoms and body mass index, and also, surgical factors have influence, for example, nerve sparing [ 12 , 13 ]. These factors can be considered for a personalized risk prediction on urinary in continence after prostatectomy.…”

Section: Anatomical Parameters To Predict Urinary Continence After Ra...mentioning

confidence: 99%

Prostate MRI for Improving Personalized Risk Prediction of Incontinence and Surgical Planning: The Role of Membranous Urethral Length Measurements and the Use of 3D Models

Boellaard

Hagens

Veerman

et al. 2023

Life

Self Cite

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Prostate MRI has an important role in prostate cancer diagnosis and treatment, including detection, the targeting of prostate biopsies, staging and guiding radiotherapy and active surveillance. However, there are other ‘’less well-known’’ applications which are being studied and frequently used in our highly specialized medical center. In this review, we focus on two research topics that lie within the expertise of this study group: (1) anatomical parameters predicting the risk of urinary incontinence after radical prostatectomy, allowing more personalized shared decision-making, with special emphasis on the membranous urethral length (MUL); (2) the use of three-dimensional models to help the surgical planning. These models may be used for training, patient counselling, personalized estimation of nerve sparing and extracapsular extension and may help to achieve negative surgical margins and undetectable postoperative PSA values.

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Conservative interventions for managing urinary incontinence after prostate surgery

Johnson

Mamoulakis

Stoniute

et al. 2023

Cochrane Database of Systematic Reviews

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Patient- and Tumour-related Prognostic Factors for Urinary Incontinence After Radical Prostatectomy for Nonmetastatic Prostate Cancer: A Systematic Review and Meta-analysis

Cited by 37 publications

References 129 publications

The development and assessment of a predicting nomogram for the recovery of immediate urinary continence following laparoscopic radical prostatectomy

The development and assessment of a predicting nomogram for the recovery of immediate urinary continence following laparoscopic radical prostatectomy

Prostate MRI for Improving Personalized Risk Prediction of Incontinence and Surgical Planning: The Role of Membranous Urethral Length Measurements and the Use of 3D Models

Conservative interventions for managing urinary incontinence after prostate surgery

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