Patient-Based Abdominal Aortic Aneurysm Rupture Risk Prediction with Fluid Structure Interaction Modeling

Xenos, Michalis; Rambhia, Suraj; Alemu, Yared; Einav, Shmuel; Labropoulos, Nicos; Tassiopoulos, Apostolos K.; Ricotta, John J.; Bluestein, Danny

doi:10.1007/s10439-010-0094-3

Cited by 91 publications

(92 citation statements)

References 65 publications

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“…The topics investigated range from heart 2 J. Lantz et al valves [Cheng et al, 2003[Cheng et al, , 2004Dahl et al, 2010;Simon et al, 2010], to estimation of wall stresses and strains in either healthy subjects [Gao et al, 2006b;McGregor et al, 2007] or in pathological cases such as aneurysms [Isaksen et al, 2008;Li and Kleinstreuer, 2005a,b;Scotti et al, 2008;Kelly and O'Rourke, 2010;Xenos et al, 2010;Tan et al, 2009]. There have also been attempts to estimate the WSS on the arterial surface [Jin et al, 2003;Gao et al, 2006a;Shahcheraghi et al, 2002].…”

Section: Introductionmentioning

confidence: 99%

Wall Shear Stress in a Subject Specific Human Aorta — Influence of Fluid-Structure Interaction

Lantz

Renner

Karlsson

2011

Int. J. Appl. Mechanics

138

106

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shear stress (WSS) has been correlated to the development of atherosclerosis in arteries. As WSS depends on the blood flow dynamics, it is sensitive to pulsatile effects and local changes in geometry. The aim of this study is therefore to investigate if the effect of wall motion changes the WSS or if a rigid wall assumption is sufficient. Magnetic resonance imaging (MRI) was used to acquire subject specific geometry and flow rates in a human aorta, which were used as inputs in numerical models. Both rigid wall models and fluid-structure interaction (FSI) models were considered, and used to calculate the WSS on the aortic wall. A physiological range of different wall stiffnesses in the FSI simulations was used in order to investigate its effect on the flow dynamics. MRI measurements of velocity in the descending aorta were used as validation of the numerical models, and good agreement was achieved. It was found that the influence of wall motion was low on time-averaged WSS and oscillating shear index, but when regarding instantaneous WSS values the effect from the wall motion was clearly visible. Therefore, if instantaneous WSS is to be investigated, a FSI simulation should be considered.

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Section: Introductionmentioning

confidence: 99%

Wall Shear Stress in a Subject Specific Human Aorta — Influence of Fluid-Structure Interaction

Lantz

Renner

Karlsson

2011

Int. J. Appl. Mechanics

138

106

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“…The AAA arises in the infrarenal aorta with a diameter greater than 3 cm and can be up to 9 cm in length [1,2]. Most of the studies on aneurysms have focused on already existing realistic or idealized aneurysms [33][34][35][36][37][38][39][40][41][42][43] with the aim of defining a relevant rupture criterion [4,7,10,19,20,24]. The ratio of the vessel stress to vessel strength is regarded as an alternative tool to conventional diameter criteria, which may be insufficient in small aneurysms.…”

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confidence: 99%

Investigation of material modeling in fluid–structure interaction analysis of an idealized three-layered abdominal aorta: aneurysm initiation and fully developed aneurysms

Şimşek

Kwon

2015

J Biol Phys

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Different material models for an idealized three-layered abdominal aorta are compared using computational techniques to study aneurysm initiation and fully developed aneurysms. The computational model includes fluid-structure interaction (FSI) between the blood vessel and the blood. In order to model aneurysm initiation, the medial region was degenerated to mimic the medial loss occurring in the inception of an aneurysm. Various cases are considered in order to understand their effects on the initiation of an abdominal aortic aneurysm. The layers of the blood vessel were modeled using either linear elastic materials or Mooney-Rivlin (otherwise known as hyperelastic) type materials. The degenerated medial region was also modeled in either linear elastic or hyperelastic-type materials and assumed to be in the shape of an arc with a thin width or a circular ring with different widths. The blood viscosity effect was also considered in the initiation mechanism. In addition, dynamic analysis of the blood vessel was performed without interaction with the blood flow by applying time-dependent pressure inside the lumen in a three-layered abdominal aorta. The stresses, strains, and displacements were compared for a healthy aorta, an initiated aneurysm and a fully developed aneurysm. The study shows that the material modeling of the vessel has a sizable effect on aneurysm initiation and fully developed aneurysms. Different material modeling of degeneration regions also affects the stressstrain response of aneurysm initiation. Additionally, the structural analysis without considering FSI (called noFSI) overestimates the peak von Mises stress by 52% at the interfaces of the layers.

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“…The solid model of AAA was simplified and idealized for this comparative study; the stress distribution and the resulted peak wall stress would exhibit wide variations on patient-specific models [26]. Constant blood pressure was applied to the inner wall of AAA and a fluid-structure interaction detail will provide more accurate stress estimation [27,28]. Despite these simplifications, the present work demonstrated the detailed biomechanics of AAA as well as its sensitivity to various factors.…”

Section: Resultsmentioning

confidence: 93%

Biomechanical prediction of abdominal aortic aneurysm rupture risk: Sensitivity analysis

Zhao¹,

Li²,

Gu³

2012

JBiSE

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Objectives: The purpose of this research is to determine the quantitative relationship between the peak wall stress of abdominal aortic aneurysm (AAA) and its clinical risk factors including its maximum diameter, asymmetry index, wall thickness and abnormal high blood pressure. Methods: The response surface experimental design with one response and four variables was used to design the experimental tests. Thirty experiments were performed through finite element analysis in order to obtain the designed response values. Results: A nonlinear multivariable regression function was developed based on the experimental data. Results demonstrated the inefficiency of traditional 5-cm criterion for estimating the rupture of AAA. The profound effect of wall thickness on the peak wall stress has been observed and validated by the existing publications. Conclusion: The conventional 5-cm criterion for estimating AAA rupture might induce biased prediction, and multiple clinical risk factors need to be considered in realistic clinical settings.

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Patient-Based Abdominal Aortic Aneurysm Rupture Risk Prediction with Fluid Structure Interaction Modeling

Cited by 91 publications

References 65 publications

Wall Shear Stress in a Subject Specific Human Aorta — Influence of Fluid-Structure Interaction

Wall Shear Stress in a Subject Specific Human Aorta — Influence of Fluid-Structure Interaction

Investigation of material modeling in fluid–structure interaction analysis of an idealized three-layered abdominal aorta: aneurysm initiation and fully developed aneurysms

Biomechanical prediction of abdominal aortic aneurysm rupture risk: Sensitivity analysis

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