Patient Benefit-Risk Preferences for Targeted Agents in the Treatment of Renal Cell Carcinoma

Abstract

A 22-month change in PFS was shown to be the most important improvement for patients. Severe fatigue/tiredness and diarrhoea were rated as the most troublesome tolerability effects of RCC treatment. Patients were likely willing to accept significant treatment-related risks of 2-3% for liver failure and blood clot to increase PFS by 11 months.

Patients’ preferences for treatment outcomes for advanced non-small cell lung cancer: A conjoint analysis

“…Fatigue was judged the most important risk, followed by diarrhoea, a finding consistent with previous research on renal cell carcinoma (RCC) [38]. Rash, nausea and vomiting, and fever and infection were all judged to be approximately equal in weight.…”

“…Survey layout followed other conjoint analysis studies applied to cancer-related topics [38][39][40].…”

Psychiatrists’ Judgments About Antipsychotic Benefit and Risk Outcomes and Formulation in Schizophrenia Treatment

“…The model estimated relative decision weights for the attribute levels shown in Table 1 that best fit the observed pattern of choices. The resulting parameter estimates thus quantified the relative importance of each attribute level (3,25,26). For the second set of choice questions, we used a bivariateprobit model to jointly estimate relative importance weights for the formulation, the chance of improvement in positive symptoms, and the change in EPS, given the patient's adherence history.…”

“…Moderate problems, marked difficulties that are clearly noticeable (still able to perform some functions without professional or social help but does so inadequately; if helped by someone, able to reach a higher level of functioning). difference between the importance weights for the best and worst levels for each attribute can be interpreted as the overall mean relative importance between the worst and best levels of that attribute, over the specific ranges included in the hypothetical treatment profiles (11,26,27). Larger mean scores indicate a greater perceived benefit.…”

Patients’ and Physicians’ Preferences for Approaches to Bone Metastases Treatment in Turkey

“…14,15 DCEs are a valid and reliable approach for assessing trade-off preferences between different health interventions. [16][17][18] In such analyses, the key attributes of a treatment are identified in order to derive preference information between hypothetical treatment options.…”