Patient-Centered Outcomes in Non-Small-Cell Lung Cancer: A Real-World Perspective

Abstract

Aims: To assess non-small-cell lung cancer (NSCLC) patient-centered outcomes in the real world. Methods: This is a prospective study of NSCLC patients treated at a private cancer care institution in Brazil between 2014 and 2019. Results: The report comprises 337 patients. Advanced stage was associated with higher symptom burden – fatigue (p = 0.03), pain (p < 0.001) and arm pain (p = 0.022) – and worse global, social and physical functioning (all p < 0.001). In the first 2 years, most factors evolved to either improvement or stability: cough (p = 0.02), pain (p = 0.002), global functioning (p < 0.001) and emotional functioning (p < 0.001). Staging (p < 0.001), fatigue (p = 0.001) and gender (p = 0.004) were independently associated with overall survival. Conclusions: Our results demonstrate the feasibility of conducting real-world prospective analysis of patient-centered outcomes.

Patient-centered Outcomes in Breast Cancer: Description of EQ-5D-5L and EORTC-QLQ-BR23 Measurements in Real-world Data and Their Association With Survival

“…A meta-analysis of EORTC trials showed that some measurements of the EORTC-QLQ-C30 questionnaire can predict mortality, regardless of clinical parameters [23]. Recently, Araujo et al [25] showed that the degree of fatigue measured in the EORTC-QLQ-30 questionnaire was an independent factor of mortality in lung cancer patients. In our cohort, overall survival was consistent with our prior report [18], which can be explained by the high incidence of early-stage disease (I Distribution of categories of baseline variables of EQ-5D-5L > 2, according to (A) staging and (B) hormone receptor/human epidermal growth factor receptor (HR/HER2) status.…”