2007
DOI: 10.1016/j.jtcvs.2006.10.087
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Patient characteristics are important determinants of neurodevelopmental outcome at one year of age after neonatal and infant cardiac surgery

Abstract: The strongest predictors of a worse neurodevelopmental outcome at 1 year of age were patient-specific factors including presence of a genetic syndrome, low birth weight, and presence of the APOE epsilon2 allele. Patient-specific factors eclipsed the use and duration of deep hypothermic circulatory arrest as predictors of worse neurodevelopmental outcomes.

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Cited by 229 publications
(182 citation statements)
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“…[81][82][83] Lower birth weight and gestational age are also associated with DD in the complex CHD population. 80,84,85 A recent study showed that late-preterm infants without CHD had the same risk for DD as very preterm infants without CHD and were at a significant risk for requiring early intervention services at a corrected age of 12 months when the study corrected for neonatal comorbidities. 86 Another study that looked at the general population found that healthy late-preterm infants (34 -36 weeks) compared with healthy term infants (Ն37 weeks) had a greater risk for developmental delay and school-related problems through the first 5 years of life.…”
Section: Prematurity And/or Developmental Delay Recognized In Infancymentioning
confidence: 99%
“…[81][82][83] Lower birth weight and gestational age are also associated with DD in the complex CHD population. 80,84,85 A recent study showed that late-preterm infants without CHD had the same risk for DD as very preterm infants without CHD and were at a significant risk for requiring early intervention services at a corrected age of 12 months when the study corrected for neonatal comorbidities. 86 Another study that looked at the general population found that healthy late-preterm infants (34 -36 weeks) compared with healthy term infants (Ն37 weeks) had a greater risk for developmental delay and school-related problems through the first 5 years of life.…”
Section: Prematurity And/or Developmental Delay Recognized In Infancymentioning
confidence: 99%
“…[3][4][5][6][7][8] These studies focused mainly on patients undergoing heart surgery. Factors identified as affecting the mental health of CHD patients in this context include coexisting syndromes (eg, Down and DiGeorge syndromes) 9,10 and familial processes (parenting styles, maternal mental health, and worry). 11 Little is known about the mental health of CHD patients who have not undergone surgery or a catheter-based intervention, although risk factors for developmental and other psychiatric disorders unrelated to surgical treatment, such as preterm birth, 12,13 occur more often than expected among CHD patients.…”
Section: Clinical Perspective On P 1712mentioning
confidence: 99%
“…This finding would be similar to the increased risk of serious complications seen in infants with congenital heart disease who contract respiratory syncytial virus 20 or infants with genetic syndromes who undergo heart surgery. 21 Alternatively, because we do not have information on do-notresuscitate status, the presence of one of these congenital anomalies may result in more withdrawal of care when an infant is infected with HSV and has a serious complication; the LOS of these children may not reflect these decisions because the decision to withdrawal care may only occur after the child's condition worsens significantly, which may happen any time during the disease course. However, this theory is less likely because we failed to find similar results with other congenital anomalies such as genetic or chromosomal syndromes.…”
Section: Discussionmentioning
confidence: 99%