Patient characteristics that predict progression of knee osteoarthritis: A systematic review of prognostic studies

Chapple, Cathy; Nicholson, Helen; Baxter, G. David; Abbott, J. Haxby

doi:10.1002/acr.20492

Cited by 126 publications

(115 citation statements)

References 47 publications

(78 reference statements)

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“…Limited evidence exists to support muscle strength as a predictor of knee OA progression (13). Yet, over time, people with knee OA who have greater quadriceps strength report less pain and superior functional ability compared to their weaker counterparts (37).…”

Section: Muscle Strengthmentioning

confidence: 99%

“…Obesity is a known risk factor for development of arthritis (12) and is a strong predictor for long-term progression of the disease (13). There is evidence that obesity is a risk factor for knee OA however the relationship between obesity and the risk of developing hip OA is less clear (14,15).…”

Section: Body Mass Indexmentioning

confidence: 99%

“…It remains unclear whether knee joint malalignment precedes incident knee OA (47,48), however varus alignment considered to be a significant predictor of knee OA disease progression (13). Knee malalignment has been demonstrated to interact with other risk factors for OA progression, increasing the likelihood of disease acceleration.…”

Section: Muscle Strengthmentioning

confidence: 99%

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Targeting Care

Eyles

Lucas

Hunter

2013

Rheumatic Disease Clinics of North America

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Important points and objectives for recall:• Numerous studies have explored patient characteristics including: body mass index, psychological factors, muscle strength, tibiofemoral alignment, radiographic changes and signs of inflammation as potential predictors of response to non-surgical interventions for management of hip and knee OA.• Often the sample sizes utilized by these studies were inadequate to yield sufficient numbers of responders to the interventions to allow for analysis of the potential predictors identified.• A number of well-designed studies were adequately powered to provide some evidence for clinical characteristics that did or did not predict response to non-surgical interventions for participants with hip and knee OA. SynopsisInternational evidence-based guidelines recommend a multitude of non-surgical treatment options for the management of OA. In the face of so many choices, it would be helpful for clinicians to be able to base treatment decisions on the identification of specific clinical presentations that foretell greater likelihood of success following a given treatment. This review summarizes the evidence available for patient characteristics that have been analysed as potential predictors of response to non-surgical interventions for patients with hip and knee OA. The specific variables targeted for this review include: body mass index, psychological factors, muscle strength, tibiofemoral alignment, radiographic changes and signs of inflammation. Several studies provide moderate to good evidence of potential predictors of response to non-surgical treatments, while areas for future research are illuminated.

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Section: Muscle Strengthmentioning

confidence: 99%

Section: Body Mass Indexmentioning

confidence: 99%

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Targeting Care

Eyles

Lucas

Hunter

2013

Rheumatic Disease Clinics of North America

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“…35,37,315 Although many of the factors associated with the future course of OA are not modifiable at the point of care (e.g. age, sex, symptom duration, severity of underlying structural changes to the joint [316][317][318][319] ) comorbid depression and anxiety are an exception as they are potentially treatable. They are related to future course, 320,321 treatment response 36 and health-care use, 322 and show a reciprocal relationship with pain and functional outcomes.…”

Section: The Hypothesis Under Testmentioning

confidence: 99%

Optimal primary care management of clinical osteoarthritis and joint pain in older people: a mixed-methods programme of systematic reviews, observational and qualitative studies, and randomised controlled trials

Hay

Dziedzic

Foster

et al. 2018

Programme Grants Appl Res

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This report should be referenced as follows:Hay E, Dziedzic K, Foster N, Peat G, van der Windt D, Bartlam B, et al. Optimal primary care management of clinical osteoarthritis and joint pain in older people: a mixed-methods programme of systematic reviews, observational and qualitative studies, and randomised controlled trials. Programme Grants Appl Res 2018;6(4). Programme Grants for Applied ResearchISSN 2050-4322 (Print) ISSN 2050-4330 (Online) This journal is a member of and subscribes to the principles of the Committee on Publication Ethics (COPE) (www.publicationethics.org/).Editorial contact: journals.library@nihr.ac.ukThe full PGfAR archive is freely available to view online at www.journalslibrary.nihr.ac.uk/pgfar. Print-on-demand copies can be purchased from the report pages of the NIHR Journals Library website: www.journalslibrary.nihr.ac.uk Criteria for inclusion in the Programme Grants for Applied Research journalReports are published in Programme Grants for Applied Research (PGfAR) if (1) they have resulted from work for the PGfAR programme, and (2) they are of a sufficiently high scientific quality as assessed by the reviewers and editors. Programme Grants for Applied Research programmeThe Programme Grants for Applied Research (PGfAR) programme, part of the National Institute for Health Research (NIHR), was set up in 2006 to produce independent research findings that will have practical application for the benefit of patients and the NHS in the relatively near future. The Programme is managed by the NIHR Central Commissioning Facility (CCF) with strategic input from the Programme Director.The programme is a national response mode funding scheme that aims to provide evidence to improve health outcomes in England through promotion of health, prevention of ill health, and optimal disease management (including safety and quality), with particular emphasis on conditions causing significant disease burden.For more information about the PGfAR programme please visit the website: http://www.nihr.ac.uk/funding/programme-grants-forapplied-research.htm This reportThe research reported in this issue of the journal was funded by PGfAR as project number RP-PG-0407-10386. The contractual start date was in July 2008. The final report began editorial review in March 2015 and was accepted for publication in May 2016. As the funder, the PGfAR programme agreed the research questions and study designs in advance with the investigators. The authors have been wholly responsible for all data collection, analysis and interpretation, and for writing up their work. The PGfAR editors and production house have tried to ensure the accuracy of the authors' report and would like to thank the reviewers for their constructive comments on the final report document. However, they do not accept liability for damages or losses arising from material published in this report.This report presents independent research funded by the National Institute for Health Research (NIHR). The views and opinions expressed by authors in this publicatio...

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“…Chronic pain prevention seems essential to avoid the decrease of QOL. Previous research has linked biomechanical [5], demographic [6], and physiological [7] factors to the progression of symptomatic OA. However, no reviews have explored the causal relationship between psychological factors and pain progression in people with knee OA.…”

Section: Introductionmentioning

confidence: 99%

Are Psychological Factors Associated with Pain Worsening in Individuals with Knee Osteoarthritis? A Systematic Review

Tanaka¹

2015

J Nov Physiother

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Patient characteristics that predict progression of knee osteoarthritis: A systematic review of prognostic studies

Abstract: Objective. To identify, by systematic review, patient characteristics that can be used by health care practitioners to predict the likelihood of knee osteoarthritis (OA) progression.

Cited by 126 publications

References 47 publications

Targeting Care

Targeting Care

Optimal primary care management of clinical osteoarthritis and joint pain in older people: a mixed-methods programme of systematic reviews, observational and qualitative studies, and randomised controlled trials

Are Psychological Factors Associated with Pain Worsening in Individuals with Knee Osteoarthritis? A Systematic Review

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