Patient Compliance with Proton Pump Inhibitor Therapy in an Otolaryngology Practice

Chheda, Neil N.; Postma, Gregory N.

doi:10.1177/000348940811700907

Cited by 6 publications

(4 citation statements)

References 13 publications

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“…Some disorders, especially common liver conditions, may cause or contribute to hyperferritinemia in persons with or without C282Y homozygosity [26]. The significant negative association of taking PPIs with SF levels that we observed in multiple regression analyses is consistent with the relatively high compliance with and protracted use of PPIs (and H2RAs) for several common therapeutic indications [27][28][29][30] and with the measured effects of PPIs on inorganic iron absorption in C282Y homozygotes who had achieved iron depletion with phlebotomy [12]. It is also possible that some of the present C282Y homozygotes who reported taking PPIs or H2RAs had lower SF due to upper gastrointestinal lesions that caused blood loss.…”

Section: Discussionsupporting

confidence: 83%

Proton Pump Inhibitors and Lower Serum Ferritin Levels in 171 HFE C282Y Homozygotes in the Hemochromatosis and Iron Overload Screening Study

Barton¹,

Adams²,

Acton³

et al. 2013

Vitam Miner

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Section: Discussionsupporting

confidence: 83%

Proton Pump Inhibitors and Lower Serum Ferritin Levels in 171 HFE C282Y Homozygotes in the Hemochromatosis and Iron Overload Screening Study

Barton¹,

Adams²,

Acton³

et al. 2013

Vitam Miner

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“…through the analysis of the prescription dispensing databank from pharmacies showed that half (44,9%) of the GERD patients ingested less than 80% of the total PPI prescribed. In the United States, Chheda et al 29 . provided similar figures: 46% of the patients interviewed were noncompliant with their prescribed PPI treatment.…”

Section: Discussionmentioning

confidence: 81%

“…28 The result of the adherence assessment obtained by Van Soest et al 28 through the analysis of the prescription dispensing databank from pharmacies showed that half (44,9%) of the GERD patients ingested less than 80% of the total PPI prescribed. In the United States, Chheda et al 29 provided similar figures: 46% of the patients interviewed were noncompliant with their prescribed PPI treatment. In addition, according to a population study, only 55% of GERD patients took a PPI once a day for 4 weeks, as prescribed.…”

Section: Discussionmentioning

confidence: 84%

Low levels of adherence with proton pump inhibitor therapy contribute to therapeutic failure in gastroesophageal reflux disease

Dal-Paz

Moraes-Filho

Navarro–Rodriguez

et al. 2011

Diseases of the Esophagus

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To assess adherence to proton pump inhibitor (PPI) treatment and associated variables in patients with gastroesophageal reflux disease (GERD). Cross-sectional and prospective comprising 240 consecutive adult patients, diagnosed with GERD for whom continuous use of standard or double dose of omeprazole had been prescribed. Patients were ranked as ne-GERD (162: 67.5%) or e-GERD classified according to the Los Angeles classification as A (48:20.0%), B (21:8.6%), C (1:0.5%), D (1:0.5%), and Barrett's esophagus (7:2.9%). The Morisky questionnaire was applied to assess adherence to therapy and a GERD questionnaire to assess symptoms and their impact. Adherence was correlated with demographics, cotherapies, comorbidities, treatment duration, symptoms scores, endoscopic findings, and patient awareness of their disease. 126 patients (52.5%) exhibited high level of adherence and 114 (47.5%) low level. Youngers (P= 0.002) or married (O.R. 2.41, P= 0.03 vs. widowers) patients had lower levels of adherence; symptomatic patients exhibited lower adherence (P= 0.02). All other variables studied had no influence on adherence. Patients with GERD attending a tertiary referral hospital in São Paulo exhibited a high rate of low adherence to the prescribed PPI therapy that may play a role in the therapy failure. Age <60 years, marital status and being symptomatic were risk factors for low adherence.

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“…The patient's compliance to proposed empiric treatments and to behavioural recommendations is often an unpredictable variable (35)(36)(37). Sequential and addictive therapies are often required and long treatment courses can break down the patient compliance, especially when the resolution of cough is not prompt.…”

Section: Additional Problemsmentioning

confidence: 99%

Chronic and unexplained cough

Zanasi¹

2014

SOB

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SummaryCough is a frequent symptom reported in general practice consults. Even though most of the cases concern acute and self limiting episodes, if cough persists a comprehensive diagnostic evaluation should be started. Patients that scarcely respond to empiric therapy or whose symptoms are not clearly referable to one of the most common causes of cough may receive the diagnosis of unexplained cough. These patients frequently develop depression or social retirement. Recent studies have suggested that hypersensitivity of the cough reflex could be the pathogenic mechanism underlying unexplained cough. However hypersensitivity syndrome should not be used as an easy way out for patients with a complicated history of cough. Through our paper we will briefly review the most common causes of cough and how they could be involved in the development of hypersensitivity cough syndrome.KEY WORDS: chronic cough; hypersensitivity syndrome; idiopathic cough; unexplained cough. IntroductionOn one hand cough represents a primary defensive mechanism of the airways. It prevents inhalation and aspiration of harmful gasses and particles from the environment and helps the mucous clearance from the lowAlthough the management of acute cough can require more than one visit, the impact on patient's quality of life is limited if compared to chronic cough.

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Patient Compliance with Proton Pump Inhibitor Therapy in an Otolaryngology Practice

Cited by 6 publications

References 13 publications

Proton Pump Inhibitors and Lower Serum Ferritin Levels in 171 HFE C282Y Homozygotes in the Hemochromatosis and Iron Overload Screening Study

Proton Pump Inhibitors and Lower Serum Ferritin Levels in 171 HFE C282Y Homozygotes in the Hemochromatosis and Iron Overload Screening Study

Low levels of adherence with proton pump inhibitor therapy contribute to therapeutic failure in gastroesophageal reflux disease

Chronic and unexplained cough

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