Patient-controlled analgesia combined with either ondansetron or ondansetron plus prochlorperazine for control of pain and nausea and vomiting in patients undergoing abdominal surgery

Jellish, W. Scott; Owen, Kevin; Fluder, Elaine; Sawicki, Kristina; Sinacore, James

doi:10.1016/j.jclinane.2008.06.008

Cited by 6 publications

(2 citation statements)

References 32 publications

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“…So far, a specific antiviral agent blocking DENV infection is lacking, and supportive care and symptomatic treatments are commonly used to treat dengue. Our finding that PCZ, a drug widely used to relieve anxiety, headache, nausea, and vomiting, common symptoms among patients with dengue [41,[47][48][49], displays potent antiviral activity against DENV infection is novel and significant. PCZ treatment in patients with dengue might have 2 beneficial effects: blocking DENV infection and relieving clinical symptoms.…”

Section: (Supplementarymentioning

confidence: 95%

Repurposing of Prochlorperazine for Use Against Dengue Virus Infection

et al. 2014

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The increasing prevalence of dengue virus (DENV) infection presents serious disease and economic burdens in countries where dengue epidemics are occurring. Despite the clinical importance, no DENV vaccine or anti-DENV drug is available. In this study, we found that prochlorperazine (PCZ), a dopamine D2 receptor (D2R) antagonist approved to treat nausea, vomiting, and headache in humans has potent in vitro and in vivo antiviral activity against DENV infection. PCZ can block DENV infection by targeting viral binding and viral entry through D2R- and clathrin-associated mechanisms, respectively. Administration of PCZ immediately or 6 hours after DENV infection in a Stat1-deficient mouse model completely protected against or delayed lethality. Overall, PCZ showed a previously unknown antiviral effect against DENV infection, and D2R may play a role in the DENV life cycle. Prophylactic and/or therapeutic treatment with PCZ might reduce viral replication and relieve the clinical symptoms of patients with dengue.

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Section: (Supplementarymentioning

confidence: 95%

Repurposing of Prochlorperazine for Use Against Dengue Virus Infection

et al. 2014

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“…Recientemente se ha alertado de la posibilidad de una interacción negativa entre ondansetrón y tramadol (117,118), lo que cuestiona la estrategia de profilaxis universal para la reducción de las NVPO (119). En cirugía abdominal se ha observado que la combinación de ondansetrón y proclorperazina a la PCA de morfina redujo más la tasa de NV que la adición de ondansetrón aislado o placebo (120). Por otra parte, un metaanálisis reciente demostró que la adición de AINES a la PCA de morfina también reduce la incidencia de NV en un 30%, de náuseas aisladas en 12% y de vómitos aislados en 32%, probablemente por disminución del consumo de morfina (121).…”

Section: Prevención Y Tratamientounclassified

Recomendaciones de prevención y tratamiento de las náuseas y vómitos postoperatorios y/o asociados a las infusiones de opioides

Gómez-Arnau

Aguilar

Bovaira

et al. 2010

Revista Española de Anestesiología y Reanimación

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Postoperative nausea and vomiting (PONV) causes patient discomfort, lowers patient satisfaction, and increases care requirements. Opioid-induced nausea and vomiting (OINV) may also occur if opioids are used to treat postoperative pain. These guidelines aim to provide recommendations for the prevention and treatment of both problems. A working group was established in accordance with the charter of the Sociedad Española de Anestesiología y Reanimación. The group undertook the critical appraisal of articles relevant to the management of PONV and OINV in adults and children early and late in the perioperative period. Discussions led to recommendations, summarized as follows: 1) Risk for PONV should be assessed in all patients undergoing surgery; 2 easy-to-use scales are useful for risk assessment: the Apfel scale for adults and the Eberhart scale for children. 2) Measures to reduce baseline risk should be used for adults at moderate or high risk and all children. 3) Pharmacologic prophylaxis with 1 drug is useful for patients at low risk (Apfel or Eberhart 1) who are to receive general anesthesia; patients with higher levels of risk should receive prophylaxis with 2 or more drugs and baseline risk should be reduced (multimodal approach). 4) Dexamethasone, droperidol, and ondansetron (or other setrons) have similar levels of efficacy; drug choice should be made based on individual patient factors. 5) The drug prescribed for treating Este trabajo ha sido financiado mediante la concesión de una subvención de ProStrakan Farmacéutica SL a la Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor.Aceptado para su publicación en agosto de 2010.Rev. Esp. Anestesiol. Reanim. 2010; 57: 508-524. Reproducido con permiso de REDAR.

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