Patient-Controlled Analgesia with Fentanyl for Burn Dressing Changes

Prakash, Smita; Fatima, Tasneem; Pawar, Mridula

doi:10.1213/01.ane.0000125110.56886.90

Cited by 51 publications

(30 citation statements)

References 16 publications

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“…Due to its high volume of distribution, prolonged administration may result in a signiicant increase in drug half-life, with consequent raise in the incidence of adverse efects [42]. Given these pharmacokinetic characteristics, there are complaint reports of patients after fentanyl administration in IV-PCA [43]. Doses and recommended parameters: demand dose: 20-50 µg; lockout: 5-10 min; Basal continuous: 0-60 µg/h [11].…”

Section: Fentanylmentioning

confidence: 99%

Patient-Controlled Analgesia (PCA) in Acute Pain: Pharmacological and Clinical Aspects

Fernandes¹,

Hernandes²,

Almeida³

et al. 2017

Pain Relief - From Analgesics to Alternative Therapies

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Moderate or severe pain are important sources of complications as well as morbidity and mortality in the postoperative period after surgical procedures. Patient-controlled analgesia (PCA) is an efective strategy for postoperative analgesia, since it may provide suitable analgesic dose just after system activation, with reduced periods of pain and an increase in patients' satisfaction. Although intravenous and epidural routes are the typical approaches used for PCA, regional patient-controlled analgesia has been shown to be an efective alternative providing a higher standard of analgesia with lower incidence of adverse efects. New devices and routes of PCA administration (transdermal, sublingual, inhalation, and oral routes) have shown to be promising alternatives in clinical studies. Nowadays, there is still no consensus regarding which is the best route or drug used since clinical eicacy/safety depends on the complex comprehension of the drugs pharmacokinetic proile through different routes of administration. Additionally, pharmacoeconomic studies are needed to evaluate the cost-efectiveness of these approaches.

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Section: Fentanylmentioning

confidence: 99%

Patient-Controlled Analgesia (PCA) in Acute Pain: Pharmacological and Clinical Aspects

Fernandes¹,

Hernandes²,

Almeida³

et al. 2017

Pain Relief - From Analgesics to Alternative Therapies

View full text Add to dashboard Cite

show abstract

“…Die patientenkontrollierte Analgesie mit Fentanyl im Rahmen von Verbandwechseln bei Verbrennungspatienten ist ein effektives Verfahren ohne Nachweis von Kreislaufinstabilität oder Atemdepression. Empfohlene Pumpeneinstellung: Bolus von 30 µg Fentanyl mit einer "lock-out time" von 5 min nach einer initialen "loading dose" mit 1 µg/kgKG Fentanyl [28].…”

Section: Verbandwechsel Von Großflächigen Verbrennungsarealen Und Klaunclassified

Schmerztherapie bei Verbrennungen

Girtler

Gustorff

2010

Anaesthesist

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Burn injuries represent a severe form of acute pain. In spite of improvements in wound treatment and pain regimens during recent years, the management of burn pain still remains a common problem and a tremendous challenge for clinical staff. An efficient pain treatment plan contributes to a fast and uneventful course and is an important part of the therapeutic management by plastic surgeons, anesthesiologists, psychologists and physiotherapists. Extensive pharmacokinetic alterations, additional neuropathic components and multiple dressing changes or therapeutic procedures need a flexible and dynamic pain strategy. A standardized continuous pain assessment and documentation are a cornerstone of burn pain control. In addition to pharmacological methods non-pharmacological procedures can play an important role and should be started early during burn patient therapy.

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“…152,176 -181 One level III 153 and four level IV prognostic studies were reviewed. 152,177,178,182 In the pharmacologic therapeutic study category, two level II, 183,184 four level III, [185][186][187][188] and four level IV studies 189 -192 were reviewed. For nonpharmacologic therapeutic studies, there was one level II study, 193 two level III studies, 194,195 and ten level IV studies.…”

Section: Painmentioning

confidence: 99%