Patient-Controlled Methylphenidate for Cancer Fatigue: A Double-Blind, Randomized, Placebo-Controlled Trial

Bruera, Éduardo; Valero, Vicente; Driver, Larry C.; Shen, Lan; Willey, Jie; Zhang, Tao; Palmer, J. Lynn

doi:10.1200/jco.2005.02.8506

Cited by 263 publications

(192 citation statements)

References 23 publications

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“…We chose the FACIT-F score as the primary outcome measure because it has been widely used in CRF treatment trials by our team and others. [40][41][42][43] Test-retest reliability coefficients for the FACIT-F have ranged from .84 to .90. 44 This scale has been shown to have strong internal consistency (α = .93-.95) and has a sensitivity of 0.92 and specificity of 0.69.…”

Section: Outcome Measuresmentioning

confidence: 99%

High-Dose Asian Ginseng (Panax Ginseng) for Cancer-Related Fatigue

et al. 2015

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Introduction and Objective. Cancer-related fatigue (CRF) is the most common and severe symptom in patients with cancer. The number and efficacy of available treatments for CRF are limited. The objective of this preliminary study was to assess the safety of high-dose Panax ginseng (PG) for CRF. Methods. In this prospective, open-label study, 30 patients with CRF (≥4/10) received high-dose PG at 800 mg orally daily for 29 days. Frequency and type of side effects were determined by the National Cancer Institute’s Common Terminology Criteria for Adverse Events, version 4.0. Scores on the Functional Assessment of Chronic Illness Therapy–Fatigue (FACIT-F) scale, Edmonton Symptom Assessment System (ESAS), and Hospital Anxiety and Depression Scale (HADS) were assessed at baseline, day 15, and day 29. Global Symptom Evaluation (GSE) was assessed at day 29. Results. Of the 30 patients enrolled, 24 (80%) were evaluable. The median age was 58 years; 50% were females, and 84% were white. No severe (≥grade 3) adverse events related to the study drug were reported. Of the 24 evaluable patients, 21 (87%) had an improved (by ≥3 points) FACIT-F score by day 15. The mean ESAS score (standard deviation) for well-being improved from 4.67 (2.04) to 3.50 (2.34) ( P = .01374), and mean score for appetite improved from 4.29 (2.79) to 2.96 (2.46) ( P = .0097). GSE score of PG for fatigue was ≥3 in 15/24 patients (63%) with median improvement of 5. Conclusion. PG is safe and improves CRF fatigue as well as overall quality of life, appetite, and sleep at night. Randomized controlled trials of PG for CRF are justified.

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Section: Outcome Measuresmentioning

confidence: 99%

High-Dose Asian Ginseng (Panax Ginseng) for Cancer-Related Fatigue

et al. 2015

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“…Ondansetron, currently approved to prevent nausea and vomiting, was shown to improve symptoms of severe fatigue in some patients with chronic liver disease, 65 and methylphenidate has shown promise in improving symptoms of fatigue in some cancer patients, although the data are not conclusive. [66][67][68] Exercise programs have helped patients with other chronic diseases improve overall health and increase energy levels and therefore have the potential to ameliorate fatigue in patients with CHC. 69 Finally, social support and patient groups are another resource for patients with CHC who are coping with disease-related effects such as fatigue.…”

Section: Side Effects Of Chc Treatment and Their Managementmentioning

confidence: 99%

The effects of HCV infection and management on health-related quality of life

2007

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“…For pharmacologic interventions, the NCCN guidelines recommend that after ruling out other causes of fatigue the use of psychostimulants should be considered. Specifically, methylphenidate has been recommended, but they are conflicting results in improving fatigue in two small, randomized, clinical trials [12,30]. With limited available options for nurses to address cancer-related fatigue, novel strategies are needed to identify effective interventions for cancer-related fatigue.…”

Section: Introductionmentioning

confidence: 99%

Association between Mitochondrial Bioenergetics and Radiation- Related Fatigue: A Possible Mechanism and Novel Target

Hsiao¹

2015

Arch Can Res

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Background: Fatigue is one of the cancer symptoms most often reported by patients receiving radiation therapy (XRT). Understanding the mechanism behind the development of cancer-related fatigue will enable the design of novel interventions for radiation-induced fatigue. This research proposal is designed to determine the association between mitochondrial bioenergetics and fatigue in prostate cancer patients receiving XRT.

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Patient-Controlled Methylphenidate for Cancer Fatigue: A Double-Blind, Randomized, Placebo-Controlled Trial

Cited by 263 publications

References 23 publications

High-Dose Asian Ginseng (Panax Ginseng) for Cancer-Related Fatigue

High-Dose Asian Ginseng (Panax Ginseng) for Cancer-Related Fatigue

The effects of HCV infection and management on health-related quality of life

Association between Mitochondrial Bioenergetics and Radiation- Related Fatigue: A Possible Mechanism and Novel Target

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