2024
DOI: 10.3389/fimmu.2024.1379613
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Patient-derived tumoroids and proteomic signatures: tools for early drug discovery

Hélène Lê,
Jules Deforges,
Pasquale Cutolo
et al.

Abstract: Onco-virotherapy is an emergent treatment for cancer based on viral vectors. The therapeutic activity is based on two different mechanisms including tumor-specific oncolysis and immunostimulatory properties. In this study, we evaluated onco-virotherapy in vitro responses on immunocompetent non-small cell lung cancer (NSCLC) patient-derived tumoroids (PDTs) and healthy organoids. PDTs are accurate tools to predict patient’s clinical responses at the in vitro stage. We showed that onco-virotherapy could exert sp… Show more

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