Patient Experience of Systemic Sclerosis–Related Calcinosis

Saketkoo, Lesley Ann; Gordon, Jessica; Fligelstone, Kim; Mawdsley, A.; Chaudhry, Humza A; Valenzuela, Antonia; Christensen, Angela M.; Khalique, Samara M; Jensen, Kelly; Weinmann, Sophia C; Busman, Evan; Chung, Lorinda; Hsu, Vivien; Russell, Anne-Marie; Steen, Virginia D.

doi:10.1016/j.rdc.2023.01.017

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…Currently, the absence of established guidelines and standardized tools hinders the evaluation of pharmacologic treatments for calcinosis in IMRD. Additionally, there are no established patient-reported outcome measures (PROMs) for IMRD-related calcinosis, except for the SCTC Mawdsley Calcinosis Questionnaire, which is currently undergoing validation [ 18 ]. Despite this therapeutic challenge, promising emerging approaches include the systemic administration of sodium thiosulfate or immunosuppressant agents [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Calcinosis in Rheumatic Disease Is Still an Unmet Need: A Retrospective Single-Center Study

Nita,

Groseanu,

Opris

et al. 2024

Diagnostics

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Patients with immune-mediated rheumatic disease-related calcinosis comprise a subgroup at risk of encountering a more severe clinical outcome. Early assessment is pivotal for preventing overall disease progression, as calcinosis is commonly overlooked until several years into the disease and is considered as a ‘non-lethal’ manifestation. This single-center retrospective study explored the prevalence, clinical associations, and impact on survival of subcutaneous calcinosis in 86 patients with immune-mediated rheumatic diseases (IMRD). Calcinosis predominantly appeared in individuals with longstanding disease, particularly systemic sclerosis (SSc), constituting 74% of cases. Smaller calcinosis lesions (≤1 cm) were associated with interstitial lung disease, musculoskeletal involvement, and digital ulcerations, while larger lesions (≥4 cm) were associated with malignancy, severe peripheral artery disease, and systemic arterial hypertension. The SSc calcinosis subgroup exhibited a higher mean adjusted European Scleroderma Study Group Activity Index score than those without. However, survival rates did not significantly differ between the two groups. Diltiazem was the most commonly used treatment, and while bisphosphonates reduced complications related to calcinosis, complete resolution was not achieved. The findings underscore current limitations in diagnosing, monitoring, and treating calcinosis, emphasizing the need for further research and improved therapeutic strategies to improve patient care and outcomes.

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Section: Introductionmentioning

confidence: 99%